The IGM Unit located in Bologna is distinguished by its ability to combine research of fundamental biological mechanisms with translational research. Five main research fields can be identified: 1) cell biology and pathology of the nucleus, 2) cell biology and pathology of the extracellular matrix, 3) cell biology and pathology of the neuro-transmitters, 4) cell biology of bone precursors and relation with biomaterials for orthopedic implant. The methodologies applied in research include: cell biology, biochemistry and molecular biology, immunolocalization and image analysis, ultrastructural analysis and study of molecules assembly.

FUNDAMENTAL MECHANISMS IN THE FUNCTION OF NUCLEAR MEMBRANE

Staff involved:

Cristina Capanni, Vittoria Cenni, Giovanna Lattanzi, Eisabetta Mattioli, Stefano Squarzoni

PATHOGENIC MECHANISMS IN LAMINOPATHIES

Staff involved:

Cristina Capanni, Vittoria Cenni, Rosalba Del Coco, Giovanna Lattanzi, Eisabetta Mattioli, Stefano Squarzoni

ORGANIZATION AND EXPRESSION OF NEW PROTEIN OF THE EXTRACELLULAR MATRIX

Staff involved:

Patrizia Sabatelli, Stefano Squarzoni

PATHOGENIC MECHANISMS IN MUSCULAR DYSTROPHY LINKED TO DEFECTS OF THE EXTRA-CELLULAR MATRIX

Staff involved:

Patrizia Sabatelli, Stefano Squarzoni

COMPARTMENTALIZATION AND TRANSMISSION MECHANISMS OF NEUROTROPHIC FACTORS

Staff involved:

Spartaco Santi

ANALYSIS OF BONE PRECURSORS AND RELATION WITH BIOMATERIALS 
Staff involved:

Nicoletta Zini

STUDY OF THE ORTHOPEDIC IMPLANTS USURY
Staff involved:

Stefano Squarzoni