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Scanning transmission electron microscopy

Staff: Stefano Squarzoni, Nicoletta Zini, Patrizia Sabatelli.

 

The use of electron microscopy associated to molecular biology has led to the identification of sub-nuclear domains involved in the organization and chromatin remodeling, in DNA replication and RNA production. The ultrastructural analysis has allowed the identification of alterations in the nuclear pathologies with defect of nuclear lamina and in some muscular dystrophies of different origin.

The analysis of very high resolution transmission electron microscopy of muscle tissue allows the identification of ultrastructural abnormalities in hereditary and acquired muscular disorders, including the muscular dystrophies.

The use of electron microscopy associated with cell biology has led to the identification of some of the mechanisms of stem cell growth on biomaterial implant.

The use of scanning electron microscopy associated with microanalysis is used for the analysis of wear for orthopedic implants.

 

 

 


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