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Vittoria Cenni


 

Istituto di Genetica Molecolare - Bologna Unit

c/o Istituto Ortopedico Rizzoli

Via di Barbiano 1/10

40136 Bologna

Phone: +39 051 6366770

Fax: +39 051 583593

Email: vittoria.cennicnr.it

 

 

Position held: Permanent position as Researcher at CNR, Institute for Molecular Genetics, Unit of Bologna;

 

Achievement of the Italian National Scientific Qualification for Associate Professor position (2014) according to the MIUR, Italian Ministry for University and Research, rules for the following scientific disciplinary sectors: Human Anatomy, Biochemistry, Molecular Biology and Applicated Biology;

 

Member of the Italian Network for Laminopathies (http://www.igm.cnr.it/1/laminopatie/)

 

Post Doc at the Laboratoy of Cellular and Muscoloskeletal Biology, Rizzoli Orthopedic Institute (IOR), Bologna(2007-08); 

 

Post Doc at C.I.Pro. (Interdipartimental Center of Proteomics), University of Modena and Reggio Emilia, Modena (2004-06); 

 

Post Doc at the Laboratoy of Cellular and Muscoloskeletal Biology, Rizzoli Orthopedic Institute (IOR), Bologna (2003-04); 

 

Ph.D. in Molecular Cytodifferentiation, Bologna Medical School, University of Bologna, Bologna (2003); 

 

Fellowship holder at the Department of Pathology at Harvard Medical School, Cambridge, MA, USA (1998-99); 

 

Degree with honors (110/110 cum laude) in Biological Sciences, Bio-Molecular field, at the University of Bologna (1997).

 

Scientific interests

Studies are principally focused on molecular mechanisms governing laminopathies, a group of genetic diseases caused by mutations of the LMNA gene. In particular, research is based on: i. the study of the interaction between LMNA products, in particular lamin A and its precursor prelamin A, and proteins involved in muscle differentiation of muscles cells obtained from control and AD-EDMD affected donors; ii. the processing and maturation of LMNA products, and the identification of molecules able to reduce prelamin A, which is accumulated to lethal or sub-lethal levels in many laminopathies, as Hutchinson-Gilford Progeria and MADA (Manybulo-Acral Dysplasia, type A) and during senescence; iii. the analysis of the interactions between Lamin A/C, DNA and other cellular proteins in lamonipathic and centenarian patients.

In the past, research has been focused on:

  • Analysis of the role of the Serine/Threonine kinases Akt1,2 and 3, their substrates and binding partners in many biological fields, as in signal transduction downstream IL-1 (Interleukin 1) and TRAIL (TNF-Related Apoptosis-Inducing ligand), in the remodelling of actin skeleton upon PDGF stimulation and during muscle differentiation. 
  • By a phosphoproteomic approach, we have been able to identify lamin A, prelamin A and Ankrd2, a mechano-sensor protein mainly expressed in cells from cardiac and skeletal tissue, as novel substrates and binding partners of Akt kinase. 
  • Studies on the regulation of PKC epsilon and PKC lambda and zeta in rat adipocytes. 

 

 

 

Laboratory technologies managed cover a wide range spanning from Cell Biology to Proteomics and Biochemistry, from Molecular Biology to Optical and Fluorescence Microscopy. 

 

Scientific activity is documented by published papers on international indexed journals and by spoken and written communication at national and international congresses. 

Ad-hoc reviewer for international journals (BioMed Research International, Molecular Cancer, Cancer Informatics and Molecular Medicine).

 

 

Publications

 


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