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Claudia Ghigna


IGM-CNR, Via Abbiategrasso, 207 - 27100 Pavia, Italy

tel: +39-0382-546324
fax: +39-0382-422286
E-mail: ghignaigm.cnr.it

 


Employment/Education

  • 2004-2005: Visiting Scientist, laboratory of Prof. Michael R. Green, Howard Hughes Medical Institute - HHMI, University of Massachusetts, Worcester, MA, USA;
  • 2001-present: Researcher Institute of Molecular Genetics, National Research Council (IGM-CNR), Pavia - Italy;
  • 2000: Advanced School of Integrated Studies (SAFI), Institute of Superior Studies, University of Pavia;
  • 2000: PhD Genetics and Molecular Biology, University of Pavia;
  • 1997: Qualified Professional Biologist, University of Pavia;

 

Research activity

Alternative splicing (AS) is an important post-transcriptional mechanism that generates from a single gene, different mRNAs coding for structurally and functionally different protein isoforms. AS is crucial for organism development and regulation of several biological processes. The human genome consists of about 20,000 protein-coding genes, a number very similar to that of much less complex organisms such as the worm Caenorhabditis elegans. Considering that almost all human genes are regulated by AS, this process represents an important mechanism underlying the expanded complexity of the human proteome. Notably, increasing evidence indicates a causative role of aberrant AS in cancer progression. Indeed, many cancer-associated genes are regulated by AS. Furthermore, recent analyzes have shown that there are many transcripts generated by AS present only in tumor cells (and not in normal cells), suggesting that these mRNAs can be used as a new diagnostic, prognostic or even therapeutic tool for human cancer.

 

 

Post-transcriptional regulation of angiogenesis 

 

 

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