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IGM-CNR, Via Abbiategrasso, 207 - 27100 Pavia, Italy 

tel: +39-0382-546330

fax: +39-0382-422286 

 

Curriculum Vitae

 

  • Researcher, IGM-CNR, Pavia (since 2009);
  • Visiting scientist at the IGBMC-CNRS, Strasbourg France (2008);
  • Research contracts at IGM-CNR, Pavia (2003-2008);
  • Telethon Postdoctoral Fellow at the IGM-CNR (2001-2002);
  • EMBO Postdoctoral Fellow at the IGM-CNR (1998-2000);
  • PhD Fellow at the European Molecular Biology Laboratories (EMBL), Heidelberg, Germany (1993-1997);
  • Graduation in Biological Sciences, University of Pavia (1991).
  • Member of the European Xeroderma Pigmentosum Society Committee (since 2015)
  • Adjunct Professor at the University of Pavia (since 2005)

 

 

 

Research activity

Extensive experience in the field of molecular biology, biochemistry and neurobiology. The present research activity focuses on the human syndromes xeroderma pigmentosum (XP), trichothiodistrophy (TTD) and Cockayne Syndrome (CS) that result from defects in nucleotide excision repair (NER), a versatile DNA repair system devoted to the removal of a wide range of lesions, including UV photoproducts. She is involved in several research projects aimed at identifying the multiple cellular functions of NER proteins and their involvement in counteracting pathological processes such as carcinogenesis, premature aging and neurodegeneration. In addition, she is involved in the cellular and molecular characterisation of patients affected by NER syndromes.

Leader of the following research projects:

 

  • UV-damage repair disorders and cancer: role of the repair/transcription complex TFIIH, founded by Associazione Italiana per la Ricerca sul Cancro (IG 17710), 2016-2019.
  • Trichothiodystrophy as a model disease to dissect the basis of TFIIH transcriptional activity, founded by CNR/CNRS, 2010-2012.
  • Identification of Rac3-interacting proteins during neuritogenesis, founded by the Italian Telethon Foundation (contract 459/bi), 2000-2002.

 

 

 

Main lines of research: 

 

  • Signaling pathways responsible for the trichothiodystrophy disorder
  • Multiple functions of Cockayne syndrome proteins and their interactors
  • Cellular and molecular characterisation of patients affected by NER syndromes

 

 

 

Research Team

 

Pubblicazioni

 


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