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Low-Coherence Reflectometry for Refractive Index Measurements of Cells in Micro-Capillaries.

Authors

Carpignano F, Rigamonti G, Mazzini G, Merlo S.

Journal

SENSORS 16(10) E1670-, 2016

CNR authors

MAZZINI

Modules

Abstract

The refractive index of cells provides insights into their composition, organization and function. Moreover, a good knowledge of the cell refractive index would allow an improvement of optical cytometric and diagnostic systems. Although interferometric techniques undoubtedly represent a good solution for quantifying optical path variation, obtaining the refractive index of a population of cells non-invasively remains challenging because of the variability in the geometrical thickness of the sample. In this paper, we demonstrate the use of infrared low-coherence reflectometry for non-invasively quantifying the average refractive index of cell populations gently confined in rectangular glass micro-capillaries. A suspension of human red blood cells in plasma is tested as a reference. As a use example, we apply this technique to estimate the average refractive index of cell populations belonging to epithelial and hematological families.

Link to article

http://www.mdpi.com/1424-8220/16/10/1670

Keywords

Note

10.3390/s16101670

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