Research Activities

IGM research activities focus on the analysis of fundamental biological processes and are integrated with a likewise qualified translational research. Three main lines of research are active: 1) molecular analysis and cellular biology of hereditary genetic diseases, 2) molecular characterization of acquired genetic diseases such as tumors and their progression to metastasis, 3) development of techniques and screening of new compounds. Research activities exploit state-of-the-art methodologies applied to molecular biology, cellular biology and bio-computing analysis of complex biological problems.
 MOLECULAR AND CELLULAR BIOLOGY OF THE NUCLEUS

THE CELL NUCLEUS AND RNA MOLECULES
Claudia Ghigna, Giuseppe Biamonti
Giuseppe Biamonti
THE CELL NUCLEUS AND DNA REPLICATION
Fiorenzo Peverali, Giuseppe Biamonti
Alessandra Montecucco, Giuseppe Biamonti, Simone Sabbioneda
NON-CODING RNA IN THE CELLULAR RESPONSE TO DNA DAMAGE
Fabrizio d'Adda di Fagagna, Sofia Francia
TRANSCRIPTION AS A SOURCE OF DNA DAMAGE DURING REPLICATION
Giordano Liberi
BASIC MECHANISMS OF THE NUCLEAR MEMBRANE FUNCTION AND PATHOGENIC MECHANISMS OF LAMINOPATHIES
Cristina Capanni, Vittoria Cenni, Rosalba Del Coco, Giovanna Lattanzi, Elisabetta Mattioli, Stefano Squarzoni
 HUMAN GENETICS AND GENOMICS

HEREDITARY DISORDERS WITH DEFECTS IN DNA REPAIR. FUNCTIONAL AND GENETIC ANALYSIS OF FACTORS INVOLVED IN GENOME STABILITY.
Miria Stefanini, Elena Botta, Tiziana Nardo, Roberta Ricotti
GENOME INSTABILITY AND CELLULAR TRANSFORMATION
Chiara Mondello, Ilaria Chiodi
GENOME INTEGRITY CHECKPOINTS OF CELL CYCLE
Ennio Prosperi
MOUSE MODELS TO STUDY GENE FUNCTION “IN VIVO” Carla Tribioli
 INNOVATIVE APPROACHES TO MOLECULAR MEDICINE: FROM NEW DRUGS DEVELOPMENT TO DIAGNOSIS

DNA ENZYMOLOGY AND MOLECULAR VIROLOGY
Giovanni Maga, Emmanuele Crespan, Federico Focher
DEVELOPMENT OF INNOVATIVE OPTICAL TECHNIQUES AND METHODS IN BIOLOGY AND BIOMEDICAL APPLICATIONS
Giuliano Mazzini, Anna Cleta Croce
LIPID SIGNALLING MOLECULES AS TARGETS IN CANCER THERAPY
William Blalock, Francesca Chiarini, Camilla Evangelisti
 COMPUTATIONAL BIOLOGY

The general topic of this group research is the analysis of the biological evolutionary mechanisms on an empirical and theoretical basis.
Empirical research regards the study of genetic migration through the spatial distribution of surnames that, considered as genetic markers, allow to follow movements of individuals and so of their genes. Other studies on evolution regarded consanguinity, genetic drift and inbreeding of the Italian population.
Utilizing information available in literature and different databases a general model for the metabolism (metabolic hypercycle) is utilized to formulate specific models for complex diseases, in particular for autoimmune diseases. COMPUTATIONAL BIOLOGY
Silvia Bione, Antonella Lisa, Ornella Fiorani, Ginevra Biino
MODELLING OF BIOLOGICAL NETWORKS
Giuseppe Damiani
 DEGENERATIVE MUSCULAR SKELETAL DISEASES

PATHOGENIC MECHANISMS IN MUSCULAR DYSTROPHIES
Vittoria Cenni, Giovanna Lattanzi, Elisabetta Mattioli, Patrizia Sabatelli, Stefano Squarzoni
CELL BIOLOGY AND PATHOLOGY OF THE EXTRA-CELLULAR MATRIX
Patrizia Sabatelli, Stefano Squarzoni
CELL BIOLOGY AND PATHOLOGY OF NEURO TRANSMITTERS
Spartaco Santi
CELL BIOLOGY OF BONE PRECURSORS AND RELATION WITH BIOMATERIALS FROM ORTHOPEDIC IMPLANTS
Nicoletta Zini
STUDY OF ORTHOPEDIC IMPLANT WEAR
Stefano Squarzoni

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