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Novel antiviral strategies against HCV/HIV infections


We are studying the replication machinery of the HCV virus with the aim of finding novel valuable targets for chemotherapy. We have already identified a potent non-nucleosidic inhibitor of the helicase activity of the viral protein NS3 (1). We are also interested in exploiting the host-virus relationships in the case of HIV infection, in order to find alternative strategies for antiviral treatment. We are currently focusing on two targets: the viral protein Vif and its cellular partners APOBEC3F/G; and the cellular protein DDX3, an RNA helicase, and its viral partner Rev (2).



  1. Maga et al., Biochemistry 2005;44:9637-44
  2. Franca et al., Med.Sci.Mon. 2006;12:92-98

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