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Novel targets for anticancer chemotherapy

 

We are exploiting a number of enzymes as targets for cancer therapy. We are currently focusing on the human terminal transferases TDT and DNA polymerase l as poential targets for treating leukemias and on tyrosine kinases such as FAK, Src-family and Abl, as targets for treatment of different type of tumors. We have already identified a number of active compounds targeting each of these enzymes (1-3).

 




 

References

  1. Di Santo R. & Maga G., Curr. Med. Chem. 2006;13:2353-68
  2. Locatelli et al., Mol. Pharm. 2005;68:538-50
  3. Manetti et al., J. Med. Chem. 2006;49:3278-86


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