Chiara Mondello

Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”
Via Abbiategrasso, 207 – 27100 PAVIA
tel: +39 0382 546332
fax: +39 0382 546370
E-mail: chiara.mondello@igm.cnr.it

Curriculum e pubblicazioni – download


Attività di Ricerca:

INSTABILITA’ GENOMICA E TRASFORMAZIONE CELLULARE

L’instabilità genomica è una caratteristica delle cellule tumorali. L’acquisizione di successive modificazioni genetiche ed epigentiche è il motore della trasformazione neoplastica. L’interesse del laboratorio verte sullo studio del processo di trasformazione e dei meccanismi di instabilità genomica. Nel nostro laboratorio è stato sviluppato un sistema cellulare costituito da fibroblasti umani immortalizzati mediante espressione ectopica della telomerasi che ricapitola il processo di trasformazione. In queste cellule, infatti, l’immortalizzazione è risultata associata alla graduale acquisizione del fenotipo neoplastico. Durante la propagazione in vitro, le cellule hanno aumentato la loro aggressività, come dimostrato dalla riduzione del tempo di latenza richiesto per indurre i tumori nei topi nudi e, nelle fasi più avanzate, sono diventate metastatiche. Confrontando cellule a diversi stadi di propagazione, abbiano potuto identificare variazioni molecolari e cellulari associate a diverse fasi della trasformazione. Abbiamo inoltre utilizzato questo sistema cellulare per approfondire le conoscenze sull’eterogeneità delle popolazioni tumorali, in particolare, sui pathway molecolari coinvolti nella genesi e nel mantenimento di sottopopolazioni di cellule tumorali con caratteristiche di staminalità ed elevata tumorigenicità. Attualmente, siamo interessati a studiare la riprogrammazione del metabolismo cellulare durante la trasformazione tumorale, con particolare attenzione all’interrelazione tra l’espressione dell’oncogene c-myc, e la bio-disponibilità degli aminoacidi non essenziali glutammina e asparagina.


Progetti di Ricerca

Interrelazione tra l’espressione dell’oncogene c-myc e la bio-disponibilità di glutammina ed asparagina in cellulare tumorali


Pubblicazioni Recenti

2021

Chiodi I; Perini C; Berardi D; Mondello C

Asparagine sustains cellular proliferation and c‑Myc expression in glutamine‑starved cancer cells Journal Article

In: Oncology reports, 45 (6), pp. 96, 2021.

Abstract | Links | BibTeX

2020

Chiodi I; Mondello C

Life Style Factors, Tumor Cell Plasticity and Cancer Stem Cells Journal Article

In: Mutation Research - Reviews in Mutation Research, 784 , pp. 108308, 2020.

Abstract | Links | BibTeX

2019

Chiodi I; Picco G; Martino C; Mondello C

Cellular response to glutamine and/or glucose deprivation in in vitro transformed human fibroblasts. Journal Article

In: Oncology reports, 41 (6), pp. 3555-3564, 2019.

Abstract | Links | BibTeX

2018

Bono B; Ostano P; Peritore M; Gregnanin I; Belgiovine C; Liguori M; Allavena P; Chiorino G; Chiodi I; Mondello C

Cells with stemness features are generated from in vitro transformed human fibroblasts. Journal Article

In: Scientific Reports, 8 (1), pp. 13838, 2018.

Abstract | Links | BibTeX

2016

Yang T; Bragheri F; Nava G; Chiodi I; Mondello C; Osellame R; Berg-Sørensen K; Cristiani I; Minzioni P

A comprehensive strategy for the analysis of acoustic compressibility and optical deformability on single cells. Journal Article

In: Scientific Reports, 6 , pp. 23946, 2016.

Abstract | Links | BibTeX

Goodson WH 3rd; Lowe L; Carpenter DO; Gilbertson M; Manaf Ali A; Lopez de Cerain Salsamendi A; Lasfar A; Carnero A; Azqueta A; Amedei A; Charles AK; Collins AR; Ward A; Salzberg AC; Colacci A; Olsen AK; Berg A; Barclay BJ; Zhou BP; Blanco-Aparicio C; Baglole CJ; Dong C; Mondello C; Hsu CW; Naus CC; Yedjou C; Curran CS; Laird DW; Koch DC; Carlin DJ; Felsher DW; Roy D; Brown DG; Ratovitski E; Ryan EP; Corsini E; Rojas E; Moon EY; Laconi E; Marongiu F; Al-Mulla F; Chiaradonna F; Darroudi F; Martin FL; Van Schooten FJ; Goldberg GS; Wagemaker G; Nangami G; Calaf GM; Williams G; Wolf GT; Koppen G; Brunborg G; Kim Lyerly H; Krishnan H; Ab Hamid H; Yasaei H; Sone H; Kondoh H; Salem HK; Hsu HY; Park HH; Koturbash I; Miousse IR; Scovassi AI; Klaunig JE; Vondráček J; Raju J; Roman J; Wise JP Sr; Whitfield JR; Woodrick J; Christopher JA; Ochieng J; Martinez-Leal JF; Weisz J; Kravchenko J; Sun J; Prudhomme KR; Narayanan KB; Cohen-Solal KA; Moorwood K; Gonzalez L; Soucek L; Jian L; D'Abronzo LS; Lin LT; Li L; Gulliver L; McCawley LJ; Memeo L; Vermeulen L; Leyns L; Zhang L; Valverde M; Khatami M; Romano MF; Chapellier M; Williams MA; Wade M; Manjili MH; Lleonart M; Xia M; Gonzalez MJ; Karamouzis MV; Kirsch-Volders M; Vaccari M; Kuemmerle NB; Singh N; Cruickshanks N; Kleinstreuer N; van Larebeke N; Ahmed N; Ogunkua O; Krishnakumar PK; Vadgama P; Marignani PA; Ghosh PM; Ostrosky-Wegman P; Thompson P; Dent P; Heneberg P; Darbre P; Sing Leung P; Nangia-Makker P; Cheng QS; Robey RB; Al-Temaimi R; Roy R; Andrade-Vieira R; Sinha RK; Mehta R; Vento R; Di Fiore R; Ponce-Cusi R; Dornetshuber-Fleiss R; Nahta R; Castellino RC; Palorini R; Abd Hamid R; Langie SA; Eltom S; Brooks SA; Ryeom S; Wise SS; Bay SN; Harris SA; Papagerakis S; Romano S; Pavanello S; Eriksson S; Forte S; Casey SC; Luanpitpong S; Lee TJ; Otsuki T; Chen T; Massfelder T; Sanderson T; Guarnieri T; Hultman T; Dormoy V; Odero-Marah V; Sabbisetti V; Maguer-Satta V; Rathmell WK; Engström W; Decker WK; Bisson WH; Rojanasakul Y; Luqmani Y; Chen Z; Hu Z Llona-Minguez S; Hoglund A; Jacques SA; Johansson L; Calderon-Montano JM; Claesson M; Loseva O; Valerie NC; Lundbäck T; Piedrafita J; Maga G; Crespan E; Meijer L; Burgos Morón E; Baranczewski P; Hagbjork AL; Svensson R; Wiita E; Almlof I; Visnes T; Jeppsson F; Sigmundsson K; Jensen AJ; Artursson P; Jemth AS; Stenmark P; Warpman Berglund U; Scobie M; Helleday T

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Journal Article

In: Journal of medicinal chemistry, 59 (3), pp. 1140-1148, 2016.

Abstract | Links | BibTeX

Belgiovine C; Chiesa G; Chiodi I; Frapolli R; Bonezzi K; Taraboletti G; D'Incalci M; Mondello C

Snail levels control the migration mechanism of mesenchymal tumor cells. Journal Article

In: Oncology Letters, 12 (1), pp. 767-771, 2016.

Abstract | Links | BibTeX

Chiodi I; Mondello C

Telomere and telomerase stability in human diseases and cancer. Journal Article

In: Frontiers In Bioscience, 21 , pp. 203-224, 2016.

Abstract | BibTeX

2015

Salvati E; Rizzo A; Iachettini S; Zizza P; Cingolani C; D'Angelo C; Porru M; Mondello C; Aiello A; Farsetti A; Gilson E; Leonetti C; Biroccio A

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds. Journal Article

In: Nucleic Acids Research, 43 (3), pp. 1759-1769, 2015.

Abstract | Links | BibTeX

Yang T; Paiè P; Nava G; Bragheri F; Martinez Vazquez R; Minzioni P; Veglione M; Di Tano M; Mondello C; Osellame R; Cristiani I

An integrated optofluidic device for single-cell sorting driven by mechanical properties. Journal Article

In: Lab on a Chip, 15 (5), pp. 1262-1266, 2015.

Abstract | Links | BibTeX

Martinez Vazquez R; Nava G; Veglione M; Yang T; Bragheri F; Minzioni P; Bianchi E; Di Tano M; Chiodi I; Osellame R; Mondello C; Cristiani I

An optofluidic constriction chip for monitoring metastatic potential and drug response of cancer cells. Journal Article

In: Integrative Biology, 7 (4), pp. 477-484, 2015.

Abstract | Links | BibTeX

Hu Z; Brooks SA; Dormoy V; Hsu CW; Hsu HY; Lin LT; Massfelder T; Rathmell WK; Xia M; Al-Mulla F; Al-Temaimi R; Amedei A; Brown DG; Prudhomme KR; Colacci A; Hamid RA; Mondello C; Raju J; Ryan EP; Woodrick J; Scovassi AI; Singh N; Vaccari M; Roy R; Forte S; Memeo L; Salem HK; Lowe L; Jensen L; Bisson WH; Kleinstreuer N

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S184-202, 2015.

Abstract | Links | BibTeX

Goodson WH 3d; Lowe L; Carpenter DO; Gilbertson M; Manaf Ali A; Lopez de Cerain Salsamendi A; Lasfar A; Carnero A; Azqueta A; Amedei A; Charles AK; Collins AR; Ward A; Salzberg AC; Colacci A; Olsen AK; Berg A; Barclay BJ; Zhou BP; Blanco-Aparicio C; Baglole CJ; Dong C; Mondello C; Hsu CW; Naus CC; Yedjou C; Curran CS; Laird DW; Koch DC; Carlin DJ; Felsher DW; Roy D; Brown DG; Ratovitski E; Ryan EP; Corsini E; Rojas E; Moon EY; Laconi E; Marongiu F; Al-Mulla F; Chiaradonna F; Darroudi F; Martin FL; Van Schooten FJ; Goldberg GS; Wagemaker G; Nangami G; Calaf GM; Williams G; Wolf GT; Koppen G; Brunborg G; Kim Lyerly H; Krishnan H; Ab Hamid H; Yasaei H; Sone H; Kondoh H; Salem HK; Hsu HY; Park HH; Koturbash I; Miousse IR; Scovassi AI; Klaunig JE; Vondráček J; Raju J; Roman J; Wise JP Sr; Whitfield JR; Woodrick J; Christopher JA; Ochieng J; Martinez-Leal JF; Weisz J; Kravchenko J; Sun J; Prudhomme KR; Narayanan KB; Cohen-Solal KA; Moorwood K; Gonzalez L; Soucek L; Jian L; D'Abronzo LS; Lin LT; Li L; Gulliver L; McCawley LJ; Memeo L; Vermeulen L; Leyns L; Zhang L; Valverde M; Khatami M; Romano MF; Chapellier M; Williams MA; Wade M; Manjili MH; Lleonart M; Xia M; Gonzalez MJ; Karamouzis MV; Kirsch-Volders M; Vaccari M; Kuemmerle NB; Singh N; Cruickshanks N; Kleinstreuer N; van Larebeke N; Ahmed N; Ogunkua O; Krishnakumar PK; Vadgama P; Marignani PA; Ghosh PM; Ostrosky-Wegman P; Thompson P; Dent P; Heneberg P; Darbre P; Sing Leung P; Nangia-Makker P; Cheng QS; Robey RB; Al-Temaimi R; Roy R; Andrade-Vieira R; Sinha RK; Mehta R; Vento R; Di Fiore R; Ponce-Cusi R; Dornetshuber-Fleiss R; Nahta R; Castellino RC; Palorini R; Abd Hamid R; Langie SA; Eltom S; Brooks SA; Ryeom S; Wise SS; Bay SN; Harris SA; Papagerakis S; Romano S; Pavanello S; Eriksson S; Forte S; Casey SC; Luanpitpong S; Lee TJ; Otsuki T; Chen T; Massfelder T; Sanderson T; Guarnieri T; Hultman T; Dormoy V; Odero-Marah V; Sabbisetti V; Maguer-Satta V; Rathmell WK; Engström W; Decker WK; Bisson WH; Rojanasakul Y; Luqmani Y; Chen Z; Hu Z

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S254-96, 2015.

Abstract | Links | BibTeX

Langie SA; Koppen G; Desaulniers D; Al-Mulla F; Al-Temaimi R; Amedei A; Azqueta A; Bisson WH; Brown D; Brunborg G; Charles AK; Chen T; Colacci A; Darroudi F; Forte S; Gonzalez L; Hamid RA; Knudsen LE; Leyns L; Lopez de Cerain Salsamendi A; Memeo L; Mondello C; Mothersill C; Olsen AK; Pavanello S; Raju J; Rojas E; Roy R; Ryan E; Ostrosky-Wegman P; Salem HK; Scovassi I; Singh N; Vaccari M; Van Schooten FJ; Valverde M; Woodrick J; Zhang L; van Larebeke N; Kirsch-Volders M; Collins AR

Causes of genome instability: the effect of low dose chemical exposures in modern society. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S61-88, 2015.

Abstract | Links | BibTeX

Kravchenko J; Corsini E; Williams MA; Decker W; Manjili MH; Otsuki T; Singh N; Al-Mulla F; Al-Temaimi R; Amedei A; Colacci AM; Vaccari M; Mondello C; Scovassi AI; Raju J; Hamid RA; Memeo L; Forte S; Roy R; Woodrick J; Salem HK; Ryan EP; Brown DG; Bisson WH; Lowe L; Lyerly HK

Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S111-27, 2015.

Abstract | Links | BibTeX

Carnero A; Blanco-Aparicio C; Kondoh H; Lleonart ME; Martinez-Leal JF; Mondello C; Ivana Scovassi A; Bisson WH; Amedei A; Roy R; Woodrick J; Colacci A; Vaccari M; Raju J; Al-Mulla F; Al-Temaimi R; Salem HK; Memeo L; Forte S; Singh N; Hamid RA; Ryan EP; Brown DG; Wise JP Sr; Wise SS; Yasaei H

Disruptive chemicals, senescence and immortality. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S19-37, 2015.

Abstract | Links | BibTeX

Narayanan KB; Ali M; Barclay BJ; Cheng Q; D'Abronzo L; Dornetshuber-Fleiss R; Ghosh PM; Gonzalez Guzman MJ; Lee TJ; Leung PS; Li L; Luanpitpong S; Ratovitski E; Rojanasakul Y; Romano MF; Romano S; Sinha RK; Yedjou C; Al-Mulla F; Al-Temaimi R; Amedei A; Brown DG; Ryan EP; Colacci A; Hamid RA; Mondello C; Raju J; Salem HK; Woodrick J; Scovassi I; Singh N; Vaccari M; Roy R; Forte S; Memeo L; Kim SY; Bisson WH; Lowe L; Park HH

Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Journal Article

In: Carcinogenesis, 36 (1), pp. S89-110, 2015.

Abstract | Links | BibTeX

Thompson PA; Khatami M; Baglole CJ; Sun J; Harris S; Moon EY; Al-Mulla F; Al-Temaimi R; Brown D; Colacci A; Mondello C; Raju J; Ryan E; Woodrick J; Scovassi I; Singh N; Vaccari M; Roy R; Forte S; Memeo L; Salem HK; Amedei A; Hamid RA; Lowe L; Guarnieri T; Bisson WH

Environmental immune disruptors, inflammation and cancer risk. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S232-253, 2015.

Abstract | Links | BibTeX

Nahta R; Al-Mulla F; Al-Temaimi R; Amedei A; Andrade-Vieira R; Bay S; G Brown D; Calaf GM; Castellino RC; Cohen-Solal KA; Colacci A; Cruickshanks N; Dent P; Di Fiore R; Forte S; Goldberg GS; Hamid RA; Krishnan H; Laird DW; Lasfar A; Marignani PA; Memeo L; Mondello C; Naus CC; Ponce-Cusi R; Raju J; Roy D; Roy R; P Ryan E; Salem HK; Scovassi AI; Singh N; Vaccari M; Vento R; Vondracek J; Wade M; Woodrick J; Bisson WH

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S2-18, 2015.

Abstract | Links | BibTeX

Robey RB; Weisz J; Kuemmerle NB; Salzberg AC; Berg A; Brown DG; Kubik L; Palorini R; Al-Mulla F; Al-Temaimi R; Colacci A; Mondello C; Raju J; Woodrick J; Scovassi AI; Singh N; Vaccari M; Roy R; Forte S; Memeo L; Salem HK; Amedei A; Hamid RA; Williams GP; Lowe L; Meyer J; Martin FL; Bisson WH; Chiaradonna F; Ryan EP

Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis? Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S203-231, 2015.

Abstract | Links | BibTeX

Casey SC; Vaccari M; Al-Mulla F; Al-Temaimi R; Amedei A; Barcellos-Hoff MH; Brown DG; Chapellier M; Christopher J; Curran C; Forte S; Hamid RA; Heneberg P; Koch DC; Krishnakumar PK; Laconi E; Maguer-Satta V; Marongiu F; Memeo L; Mondello C; Raju J; Roman J; Roy R; Ryan EP; Ryeom S; Salem HK; Scovassi AI; Singh N; Soucek L; Vermeulen L; Whitfield JR; Woodrick J; Colacci A; Bisson WH; Felsher DW

The effect of environmental chemicals on the tumor microenvironment. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S160-183, 2015.

Abstract | Links | BibTeX

Ochieng J; Nangami GN; Ogunkua O; Miousse IR; Koturbash I; Odero-Marah V; McCawley L; Nangia-Makker P; Ahmed N; Luqmani Y; Chen Z; Papagerakis S; Wolf GT; Dong C; Zhou BP; Brown DG; Colacci A; Hamid RA; Mondello C; Raju J; Ryan EP; Woodrick J; Scovassi I; Singh N; Vaccari M; Roy R; Forte S; Memeo L; Salem HK; Amedei A; Al-Temaimi R; Al-Mulla F; Bisson WH; Eltom SE

The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S128-159, 2015.

Abstract | Links | BibTeX

Engstrom W; Darbre P; Eriksson S; Gulliver L; Hultman T; Karamouzis MV; Klaunig JE; Mehta R; Moorwood K; Sanderson T; Sone H; Vadgama P; Wagemaker G; Ward A; Singh N; Al-Mulla F; Al-Temaimi R; Amedei A; Colacci AM; Vaccari M; Mondello C; Scovassi AI; Raju J; Hamid RA; Memeo L; Forte S; Roy R; Woodrick J; Salem HK; Ryan E; Brown DG; Bisson WH

The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling. Journal Article

In: Carcinogenesis, 36 (Suppl. 1), pp. S38-60, 2015.

Abstract | Links | BibTeX

2008

Mondello C

Multiple Pathways in cancer development. Book

Transworld Research Network, Trivandrum, 2008, ISBN: 9788178953625.

BibTeX