Nicoletta Zini


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 6366771

E-mail: nicoletta.zini@cnr.it

Curriculum Vitae – Download

Elenco completo delle pubblicazioni – Download


Attività di ricerca

Italiano

L’attività di ricerca riguarda studi sull’ ultrastruttura e funzioni del nucleo interfasico, l’analisi funzionale della distribuzione intranucleare dei diversi elementi del sistema di trasduzione del segnale inositide-dipendente.

Più recentemente sono stati valutati, mediante analisi in microscopia elettronica, il differenziamento osteogenico e condrogenico di progenitori cellulari cresciuti su materiali biocompatibili, al fine di chiarire alcuni aspetti dell’ interazione cellule/matrice extracellulare e biomateriali impiegabili nei processi riparativi dell’osso e della cartilagine.  

Ulteriori studi sono stati condotti per analizzare il comportamento di cellule cresciute su scaffold biocompatibili 3-D che riproducono parte della morfologia degli organi adulti.

Inoltre sono  stati caratterizzati esosomi da  diversi modelli cellulari con il fine di dimostrare il loro ruolo nella comunicazione tra cellule.

Competenze:  microscopia elettronica a trasmissione e relative metodiche di allestimento dei preparati, immunocitochimica ultrastrutturale, immunofluorescenza, microscopia ottica.


Progetti di ricerca

  • Progetto europeo Horizon 2020-SCREENED EU 2019-2023, grant N° 825745: “A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner”.  Responsabile presso IGM-CNR:  Dott.ssa Nicoletta Zini,  afferente all’Unità di Ricerca SCREENED coordinata dal Prof. Dott. Roberto Toni, Università di Parma.


Gruppo di ricerca

Despina Kiriakidu, tecnico di laboratorio IGM-CNR

 


Pubblicazioni Recenti

2021

Bottega R; Ravera S; Napolitano LMR; Chiappetta V; Zini N; Crescenzi B; Arniani S; Faleschini M; Cortone G; Faletra F; Medagli B; Sirchia F; Moretti M; de Lange J; Cappelli E; Mecucci C; Onesti S; Pisani FM; Savoia A

Mitochondrial defect in Warsaw syndrome cells genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: A comparison with Fanconi anemia. Journal Article

In: Journal of cellular physiology, 236 (8), pp. 5664-5675, 2021.

Abstract | Links | BibTeX

Costa R; Rodia MT; Zini N; Pegoraro V; Marozzo R; Capanni C; Angelini C; Lattanzi G; Santi S; Cenacchi G

Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Journal Article

In: Molecular and cellular biochemistry, 476 (4), pp. 1797-1811, 2021.

Abstract | Links | BibTeX

Sartore L; Manferdini C; Saleh Y; Dey K; Gabusi E; Ramorino G; Zini N; Almici C; Re F; Russo D; Mariani E; Lisignoli G

Polysaccharides on gelatin-based hydrogels differently affect chondrogenic differentiation of human mesenchymal stromal cells Journal Article

In: Materials science & engineering. C, Materials for biological applications, 126 , pp. 112175, 2021.

Abstract | Links | BibTeX

Cavallo C; Merli G; Borzì RM; Zini N; D'Adamo S; Guescini M; Grigolo B; Di Martino A; Santi S; Filardo G

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-kappaB dependent inflammatory/catabolic environment of osteoarthritis. Journal Article

In: Scientific Reports, 11 (1), pp. 1053, 2021.

Abstract | Links | BibTeX

Perut F; Roncuzzi L; Avnet S; Massa A; Zini N; Sabbadini S; Giampieri F; Mezzetti B; Baldini N

Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells Journal Article

In: Biomolecules, 11 (1), pp. e87, 2021.

Abstract | Links | BibTeX

2020

Toni R; Di Conza G; Barbaro F; Zini N; Consolini E; Dallatana D; Antoniel M; Quarantini E; Quarantini M; Maioli S; Bruni CA; Elviri L; Panseri S; Sprio S; Sandri M; Tampieri A

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors. Journal Article

In: Frontiers in immunology, 11 , pp. 1737, 2020.

Abstract | Links | BibTeX

2019

Boriani F; Savarino L; Fazio N; Pedrini FA; Fini M; Nicoli Aldini N; Martini L; Zini N; Bernardini M; Bolognesi F; Marchetti C; Baldini N

Auto-Allo Graft Parallel Juxtaposition for Improved Neuroregeneration in Peripheral Nerve Reconstruction Based on Acellular Nerve Allografts. Journal Article

In: Annals of plastic surgery, 83 (3), pp. 318-325, 2019.

Abstract | Links | BibTeX

Manferdini C; Gabusi E; Sartore L; Dey K; Agnelli S; Almici C; Bianchetti A; Zini N; Russo D; Re F; Mariani E; Lisignoli G

Chitosan-based scaffold counteracts hypertrophic and fibrotic markers in chondrogenic differentiated mesenchymal stromal cells. Journal Article

In: Journal of tissue engineering and regenerative medicine, 13 (10), pp. 1896-1911, 2019.

Abstract | Links | BibTeX

Perut F; Roncuzzi L; Zini N; Massa A; Baldini N

Extracellular Nanovesicles Secreted by Human Osteosarcoma Cells Promote Angiogenesis. Journal Article

In: Cancers (Basel), 11 (6), pp. e779, 2019.

Abstract | Links | BibTeX

Barbaro F; Consolini E; Toscani G; Zini N; Dallatana D; Setti P; Mosca S; Di Conza G; Bassi E; Quarantini E; Quarantini M; Raposio E; Gorreri M; Porro A; Toni R.

The masks of Lorenzo Tenchini: their anatomy and surgical/bioengineering clues. Journal Article

In: Journal of anatomy, 235 (6), pp. 1036-1044, 2019.

Abstract | Links | BibTeX

2018

Diomede F; Zini N; Pizzicannella J; Merciaro I; Pizzicannella G; D'Orazio M; Piattelli A; Trubiani O

5-Aza Exposure Improves Reprogramming Process Through Embryoid Body Formation in Human Gingival Stem Cells. Journal Article

In: Frontiers in genetics, 9 , pp. 419, 2018.

Abstract | Links | BibTeX

Baldini N; Torreggiani E; Roncuzzi L; Perut F; Zini N; Avnet S

Exosome-like nanovesicles isolated from Citrus limon L. exert antioxidative effect. Journal Article

In: Current pharmaceutical biotechnology, 19 (11), pp. 877-885, 2018.

Abstract | Links | BibTeX

Manferdini C; Zini N; Gabusi E; Paolella F; Lambertini E; Penolazzi L; Piva R; Lisignoli G

Immunoelectron microscopic localization of Collagen type XV during human mesenchymal stem cells mineralization. Journal Article

In: Connective tissue research, 59 (Suppl. 1), pp. 42-45, 2018.

Abstract | Links | BibTeX

2017

Boriani F; Fazio N; Fotia C; Savarino L; Nicoli Aldini N; Martini L; Zini N; Bernardini M; Baldini N

A novel technique for decellularization of allogenic nerves and in vivo study of their use for peripheral nerve reconstruction. Journal Article

In: Journal of biomedical materials research. Part A, 105 (8), pp. 2228-2240, 2017.

Abstract | Links | BibTeX

Baglio SR; Lagerweij T; Pérez-Lanzón M; Ho XD; Léveillé N; Melo SA; Cleton-Jansen AM; Jordanova ES; Roncuzzi L; Greco M; van Eijndhoven MAJ; Grisendi G; Dominici M; Bonafede R; Lougheed SM; de Gruijl TD; Zini N; Cervo S; Steffan A; Canzonieri V; Martson A; Maasalu K; Köks S; Wurdinger T; Baldini N; Pegtel DM

Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression. Journal Article

In: Clinical cancer research, 23 (14), pp. 3721-3733, 2017.

Abstract | Links | BibTeX

2016

Avnet S; Lemma S; Cortini M; Pellegrini P; Perut F; Zini N; Kusuzaki K; Chano T; Grisendi G; Dominici M; De Milito A; Baldini N

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance. Journal Article

In: Oncotarget, 7 (39), pp. 63408-63423, 2016.

Abstract | Links | BibTeX

Manara MC; Terracciano M; Mancarella C; Sciandra M; Guerzoni C; Pasello M; Grilli A; Zini N; Picci P; Colombo MP; Morrione A; Scotlandi K

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Journal Article

In: Oncotarget, 7 (48), pp. 79925-79942, 2016.

Abstract | Links | BibTeX

Lemma S; Sboarina M; Porporato PE; Zini N; Sonveaux P; Di Pompo G; Baldini N; Avnet S

Energy metabolism in osteoclast formation and activity. Journal Article

In: International Journal of Biochemistry And Cell Biology, 79 , pp. 168-180, 2016.

Abstract | Links | BibTeX

Diomede F; Zini N; Gatta V; Fulle S; Merciaro I; D'Aurora M; La Rovere RM; Traini T; Pizzicannella J; Ballerini P; Caputi S; Piattelli A; Trubiani O

Human periodontal ligament stem cells cultured onto cortico-cancellous scaffold drive bone regenerative process. Journal Article

In: European Cells & Materials, 32 , pp. 181-201, 2016.

Abstract | Links | BibTeX

Cavallo C; Desando G; Ferrari A; Zini N; Mariani E; Grigolo B

Hyaluronan scaffold supports osteogenic differentiation of bone marrow concentrate cells. Journal Article

In: Journal of Biological Regulators and Homeostatic Agents, 30 (2), pp. 409-420, 2016.

Abstract | Links | BibTeX

Torreggiani E; Roncuzzi L; Perut F; Zini N; Baldini N

Multimodal transfer of MDR by exosomes in human osteosarcoma Journal Article

In: International Journal of Oncology, 49 (1), pp. 189-196, 2016.

Abstract | Links | BibTeX

Koppers-Lalic D; Hackenberg M; Menezes R; Misovic B; Wachalska M; Geldof A; Zini N; Reijke T; Wurdinger T; Vis A; Moorselaar JV; Pegtel M; Bijnsdorp I

Non‑invasive prostate cancer detection by measuring miRNA variants (isomiRs) in urine extracellular vesicles. Journal Article

In: Oncotarget, 7 (16), pp. 22566-22578, 2016.

Abstract | Links | BibTeX

Manescu A; Giuliani A; Mohammadi S; Tromba G; Mazzoni S; Diomede F; Zini N; Piattelli A; Trubiani O

Osteogenic potential of dualblocks cultured with human periodontal ligament stem cells: in vitro and synchrotron microtomography study. Journal Article

In: Journal of Periodontal Research, 51 (1), pp. 112-124, 2016.

Abstract | Links | BibTeX

Manferdini C; Cavallo C; Grigolo B; Fiorini M; Nicoletti A; Gabusi E; Zini N; Pressato D; Facchini A; Lisignoli G

Specific inductive potential of a novel nanocomposite biomimetic biomaterial for osteochondral tissue regeneration Journal Article

In: Journal of Tissue Engineering and Regenerative Medicine, 10 , pp. 374-391, 2016.

Abstract | Links | BibTeX

2015

Trubiani O; Piattelli A; Gatta V; Marchisio M; Diomede F; D'Aurora M; Merciaro I; Pierdomenico L; Maraldi NM; Zini N

Assessment of an efficient xeno-free culture system for human periodontal ligament stem cells. Journal Article

In: Tissue Engineering. Part C, Methods, 21 (1), pp. 52-64, 2015.

Abstract | Links | BibTeX

Baglio SR; Rooijers K; Koppers-Lalic D; Verweij FJ; Perez Lanzon M; Zini N; Naaijkens B; Perut F; Niessen HW; Baldini N; Pegtel DM

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Journal Article

In: Stem Cell Research & Therapy, 6 , pp. 127, 2015.

Abstract | Links | BibTeX

Grigolo B; Cavallo C; Desando G; Manferdini C; Lisignoli G; Ferrari A; Zini N; Facchini A

Novel nano-composite biomimetic biomaterial allows chondrogenic and osteogenic differentiation of bone marrow concentrate derived cells. Journal Article

In: Journal of Materials Science. Materials in Medicine, 26 (4), pp. 173, 2015.

Abstract | Links | BibTeX

Lambertini E; Penolazzi L; Morganti C; Lisignoli G; Zini N; Angelozzi M; Bonora M; Ferroni L; Pinton P; Zavan B; Piva R

Osteogenic differentiation of human MSCs: Specific occupancy of the mitochondrial DNA by NFATc1 transcription factor. Journal Article

In: International Journal of Biochemistry & Cell Biology, 64 , pp. 212-219, 2015.

Abstract | Links | BibTeX