Nicoletta Zini


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 6366771

E-mail: nicoletta.zini@cnr.it

Curriculum Vitae – Download

Elenco completo delle pubblicazioni – Download


Attività di ricerca

Italiano

L’attività di ricerca riguarda studi sull’ ultrastruttura e funzioni del nucleo interfasico, l’analisi funzionale della distribuzione intranucleare dei diversi elementi del sistema di trasduzione del segnale inositide-dipendente.

Più recentemente sono stati valutati, mediante analisi in microscopia elettronica, il differenziamento osteogenico e condrogenico di progenitori cellulari cresciuti su materiali biocompatibili, al fine di chiarire alcuni aspetti dell’ interazione cellule/matrice extracellulare e biomateriali impiegabili nei processi riparativi dell’osso e della cartilagine.  

Ulteriori studi sono stati condotti per analizzare il comportamento di cellule cresciute su scaffold biocompatibili 3-D che riproducono parte della morfologia degli organi adulti.

Inoltre sono  stati caratterizzati esosomi da  diversi modelli cellulari con il fine di dimostrare il loro ruolo nella comunicazione tra cellule.

Competenze:  microscopia elettronica a trasmissione e relative metodiche di allestimento dei preparati, immunocitochimica ultrastrutturale, immunofluorescenza, microscopia ottica.


Progetti di ricerca

  • Progetto europeo Horizon 2020-SCREENED EU 2019-2023, grant N° 825745: “A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner”.  Responsabile presso IGM-CNR:  Dott.ssa Nicoletta Zini,  afferente all’Unità di Ricerca SCREENED coordinata dal Prof. Dott. Roberto Toni, Università di Parma.


Gruppo di ricerca

Despina Kiriakidu, tecnico di laboratorio IGM-CNR

 


Pubblicazioni Recenti

2021

Bottega R; Ravera S; Napolitano LMR; Chiappetta V; Zini N; Crescenzi B; Arniani S; Faleschini M; Cortone G; Faletra F; Medagli B; Sirchia F; Moretti M; de Lange J; Cappelli E; Mecucci C; Onesti S; Pisani FM; Savoia A

Mitochondrial defect in Warsaw syndrome cells genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: A comparison with Fanconi anemia. Journal Article Forthcoming

Journal of cellular physiology, Forthcoming.

Abstract | Links | BibTeX

Costa R; Rodia MT; Zini N; Pegoraro V; Marozzo R; Capanni C; Angelini C; Lattanzi G; Santi S; Cenacchi G

Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Journal Article

Molecular and cellular biochemistry, 476 (4), pp. 1797-1811, 2021.

Abstract | Links | BibTeX

Cavallo C; Merli G; Borzì RM; Zini N; D'Adamo S; Guescini M; Grigolo B; Di Martino A; Santi S; Filardo G

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-kappaB dependent inflammatory/catabolic environment of osteoarthritis. Journal Article

Scientific Reports, 11 (1), pp. 1053, 2021.

Abstract | Links | BibTeX

Perut F; Roncuzzi L; Avnet S; Massa A; Zini N; Sabbadini S; Giampieri F; Mezzetti B; Baldini N

Strawberry-Derived Exosome-Like Nanoparticles Prevent Oxidative Stress in Human Mesenchymal Stromal Cells Journal Article

Biomolecules, 11 (1), pp. e87, 2021.

Abstract | Links | BibTeX

2020

Toni R; Di Conza G; Barbaro F; Zini N; Consolini E; Dallatana D; Antoniel M; Quarantini E; Quarantini M; Maioli S; Bruni CA; Elviri L; Panseri S; Sprio S; Sandri M; Tampieri A

Microtopography of Immune Cells in Osteoporosis and Bone Lesions by Endocrine Disruptors. Journal Article

Frontiers in immunology, 11 , pp. 1737, 2020.

Abstract | Links | BibTeX

2019

Boriani F; Savarino L; Fazio N; Pedrini FA; Fini M; Nicoli Aldini N; Martini L; Zini N; Bernardini M; Bolognesi F; Marchetti C; Baldini N

Auto-Allo Graft Parallel Juxtaposition for Improved Neuroregeneration in Peripheral Nerve Reconstruction Based on Acellular Nerve Allografts. Journal Article

Annals of plastic surgery, 83 (3), pp. 318-325, 2019.

Abstract | Links | BibTeX

Manferdini C; Gabusi E; Sartore L; Dey K; Agnelli S; Almici C; Bianchetti A; Zini N; Russo D; Re F; Mariani E; Lisignoli G

Chitosan-based scaffold counteracts hypertrophic and fibrotic markers in chondrogenic differentiated mesenchymal stromal cells. Journal Article

Journal of tissue engineering and regenerative medicine, 13 (10), pp. 1896-1911, 2019.

Abstract | Links | BibTeX

Perut F; Roncuzzi L; Zini N; Massa A; Baldini N

Extracellular Nanovesicles Secreted by Human Osteosarcoma Cells Promote Angiogenesis. Journal Article

Cancers (Basel), 11 (6), pp. e779, 2019.

Abstract | Links | BibTeX

Barbaro F; Consolini E; Toscani G; Zini N; Dallatana D; Setti P; Mosca S; Di Conza G; Bassi E; Quarantini E; Quarantini M; Raposio E; Gorreri M; Porro A; Toni R.

The masks of Lorenzo Tenchini: their anatomy and surgical/bioengineering clues. Journal Article

Journal of anatomy, 235 (6), pp. 1036-1044, 2019.

Abstract | Links | BibTeX

2018

Diomede F; Zini N; Pizzicannella J; Merciaro I; Pizzicannella G; D'Orazio M; Piattelli A; Trubiani O

5-Aza Exposure Improves Reprogramming Process Through Embryoid Body Formation in Human Gingival Stem Cells. Journal Article

Frontiers in genetics, 9 , pp. 419, 2018.

Abstract | Links | BibTeX

Baldini N; Torreggiani E; Roncuzzi L; Perut F; Zini N; Avnet S

Exosome-like nanovesicles isolated from Citrus limon L. exert antioxidative effect. Journal Article

Current pharmaceutical biotechnology, 19 (11), pp. 877-885, 2018.

Abstract | Links | BibTeX

Manferdini C; Zini N; Gabusi E; Paolella F; Lambertini E; Penolazzi L; Piva R; Lisignoli G

Immunoelectron microscopic localization of Collagen type XV during human mesenchymal stem cells mineralization. Journal Article

Connective tissue research, 59 (Suppl. 1), pp. 42-45, 2018.

Abstract | Links | BibTeX

2017

Boriani F; Fazio N; Fotia C; Savarino L; Nicoli Aldini N; Martini L; Zini N; Bernardini M; Baldini N

A novel technique for decellularization of allogenic nerves and in vivo study of their use for peripheral nerve reconstruction. Journal Article

Journal of biomedical materials research. Part A, 105 (8), pp. 2228-2240, 2017.

Abstract | Links | BibTeX

Baglio SR; Lagerweij T; Pérez-Lanzón M; Ho XD; Léveillé N; Melo SA; Cleton-Jansen AM; Jordanova ES; Roncuzzi L; Greco M; van Eijndhoven MAJ; Grisendi G; Dominici M; Bonafede R; Lougheed SM; de Gruijl TD; Zini N; Cervo S; Steffan A; Canzonieri V; Martson A; Maasalu K; Köks S; Wurdinger T; Baldini N; Pegtel DM

Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression. Journal Article

Clinical cancer research, 23 (14), pp. 3721-3733, 2017.

Abstract | Links | BibTeX

2016

Avnet S; Lemma S; Cortini M; Pellegrini P; Perut F; Zini N; Kusuzaki K; Chano T; Grisendi G; Dominici M; De Milito A; Baldini N

Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance. Journal Article

Oncotarget, 7 (39), pp. 63408-63423, 2016.

Abstract | Links | BibTeX

Manara MC; Terracciano M; Mancarella C; Sciandra M; Guerzoni C; Pasello M; Grilli A; Zini N; Picci P; Colombo MP; Morrione A; Scotlandi K

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling. Journal Article

Oncotarget, 7 (48), pp. 79925-79942, 2016.

Abstract | Links | BibTeX

Lemma S; Sboarina M; Porporato PE; Zini N; Sonveaux P; Di Pompo G; Baldini N; Avnet S

Energy metabolism in osteoclast formation and activity. Journal Article

International Journal of Biochemistry And Cell Biology, 79 , pp. 168-180, 2016.

Abstract | Links | BibTeX

Diomede F; Zini N; Gatta V; Fulle S; Merciaro I; D'Aurora M; La Rovere RM; Traini T; Pizzicannella J; Ballerini P; Caputi S; Piattelli A; Trubiani O

Human periodontal ligament stem cells cultured onto cortico-cancellous scaffold drive bone regenerative process. Journal Article

European Cells & Materials, 32 , pp. 181-201, 2016.

Abstract | Links | BibTeX

Cavallo C; Desando G; Ferrari A; Zini N; Mariani E; Grigolo B

Hyaluronan scaffold supports osteogenic differentiation of bone marrow concentrate cells. Journal Article

Journal of Biological Regulators and Homeostatic Agents, 30 (2), pp. 409-420, 2016.

Abstract | Links | BibTeX

Torreggiani E; Roncuzzi L; Perut F; Zini N; Baldini N

Multimodal transfer of MDR by exosomes in human osteosarcoma Journal Article

International Journal of Oncology, 49 (1), pp. 189-196, 2016.

Abstract | Links | BibTeX

Koppers-Lalic D; Hackenberg M; Menezes R; Misovic B; Wachalska M; Geldof A; Zini N; Reijke T; Wurdinger T; Vis A; Moorselaar JV; Pegtel M; Bijnsdorp I

Non‑invasive prostate cancer detection by measuring miRNA variants (isomiRs) in urine extracellular vesicles. Journal Article

Oncotarget, 7 (16), pp. 22566-22578, 2016.

Abstract | Links | BibTeX

Manescu A; Giuliani A; Mohammadi S; Tromba G; Mazzoni S; Diomede F; Zini N; Piattelli A; Trubiani O

Osteogenic potential of dualblocks cultured with human periodontal ligament stem cells: in vitro and synchrotron microtomography study. Journal Article

Journal of Periodontal Research, 51 (1), pp. 112-124, 2016.

Abstract | Links | BibTeX

Manferdini C; Cavallo C; Grigolo B; Fiorini M; Nicoletti A; Gabusi E; Zini N; Pressato D; Facchini A; Lisignoli G

Specific inductive potential of a novel nanocomposite biomimetic biomaterial for osteochondral tissue regeneration Journal Article

Journal of Tissue Engineering and Regenerative Medicine, 10 , pp. 374-391, 2016.

Abstract | Links | BibTeX

2015

Trubiani O; Piattelli A; Gatta V; Marchisio M; Diomede F; D'Aurora M; Merciaro I; Pierdomenico L; Maraldi NM; Zini N

Assessment of an efficient xeno-free culture system for human periodontal ligament stem cells. Journal Article

Tissue Engineering. Part C, Methods, 21 (1), pp. 52-64, 2015.

Abstract | Links | BibTeX

Baglio SR; Rooijers K; Koppers-Lalic D; Verweij FJ; Perez Lanzon M; Zini N; Naaijkens B; Perut F; Niessen HW; Baldini N; Pegtel DM

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Journal Article

Stem Cell Research & Therapy, 6 , pp. 127, 2015.

Abstract | Links | BibTeX

Grigolo B; Cavallo C; Desando G; Manferdini C; Lisignoli G; Ferrari A; Zini N; Facchini A

Novel nano-composite biomimetic biomaterial allows chondrogenic and osteogenic differentiation of bone marrow concentrate derived cells. Journal Article

Journal of Materials Science. Materials in Medicine, 26 (4), pp. 173, 2015.

Abstract | Links | BibTeX

Lambertini E; Penolazzi L; Morganti C; Lisignoli G; Zini N; Angelozzi M; Bonora M; Ferroni L; Pinton P; Zavan B; Piva R

Osteogenic differentiation of human MSCs: Specific occupancy of the mitochondrial DNA by NFATc1 transcription factor. Journal Article

International Journal of Biochemistry & Cell Biology, 64 , pp. 212-219, 2015.

Abstract | Links | BibTeX

2014

Lisignoli G; Manferdini C; Lambertini E; Zini N; Angelozzi M; Gabusi E; Gambari L; Penolazzi L; Lolli A; Facchini A; Piva R

Chondrogenic potential of Slug-depleted human mesenchymal stem cells. Journal Article

Tissue engineering. Part A, 20 , pp. 2795-2805, 2014, ISSN: 1937-3341.

Abstract | Links | BibTeX

Torreggiani E; Perut F; Roncuzzi L; Zini N; Baglìo SR; Baldini N

Exosomes: novel effectors of human platelet lysate activity. Journal Article

European Cells & Materials, 28 , pp. 137-151, 2014, ISSN: 1473-2262.

Abstract | Links | BibTeX

Zamparelli A; Zini N; Cattini L; Spaletta G; Dallatana D; Bassi E; Barbaro F; Iafisco M; Mosca S; Parrilli A; Fini M; Giardino R; Sandri M; Sprio S; Tampieri A; Maraldi NM; Toni R

Growth on poly(L-lactic acid) porous scaffold preserves CD73 and CD90 immunophenotype markers of rat bone marrow mesenchymal stromal cells Journal Article

Journal of materials science. Materials in medicine, 25 , pp. 2421-2436, 2014, ISSN: 0957-4530.

Abstract | Links | BibTeX

Zulian A; Tagliavini F; Rizzo E; Pellegrini C; Sardone F; Zini N; Maraldi NM; Santi S; Faldini C; Merlini L; Petronilli V; Bernardi P; Sabatelli P

Melanocytes from Patients Affected by Ullrich Congenital Muscular Dystrophy and Bethlem Myopathy have Dysfunctional Mitochondria That Can be Rescued with Cyclophilin Inhibitors. Journal Article

Frontiers in Aging Neuroscience, 6 , pp. 324, 2014, ISSN: 1663-4365.

Abstract | Links | BibTeX