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Poly(ADP-ribosylation) and neurodegenerative disorders.

Authors

Basello DA, Scovassi AI.

Journal

MITOCHONDRION 24 56-63, 2015

CNR authors

SCOVASSI

Modules

Abstract

Impaired mitochondrial structure and function are common features of neurodegenerative disorders, ultimately characterized by the death of neural cells promoted by still unknown signals. Among the possible modulators of neurodegeneration, the activation of poly(ADP-ribosylation), a post-translational modification of proteins, has been considered, being the product of the reaction, poly(ADP-ribose), a signaling molecule for different cell death paradigms. The basic properties of poly(ADP-ribosylation) are here described, focusing on the mitochondrial events; cell death paradigms such as apoptosis, parthanatos, necroptosis and mitophagy are illustrated. Finally, the promising use of poly(ADP-ribosylation) inhibitors to rescue neurodegeneration is addressed. Copyright 2015 Elsevier B.V. and Mitochondria Research Society. Published by Elsevier B.V. All rights reserved.

Link to article

http://www.sciencedirect.com/science/article/pii/S156772491530012X

Keywords

Note

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