Pubblicazioni IGM

Heritability of young- and old-onset ischaemic stroke.


Bluher A, Devan WJ, Holliday EG, Nalls M, Parolo S, Bione S, Giese AK, Boncoraglio GB, Maguire JM, Muller-Nurasyid M, Gieger C, Meschia JF, Rosand J, Rolfs A, Kittner SJ, Mitchell BD, O'Connell JR, Cheng YC.


EUROPEAN JOURNAL OF NEUROLOGY 22(11) 1488-1491, 2015

Autori CNR




Although the genetic contribution to stroke risk is well known, it remains unclear if young-onset stroke has a stronger genetic contribution than old-onset stroke. This study aims to compare the heritability of ischaemic stroke risk between young and old, using common genetic variants from whole-genome array data in population-based samples. METHODS: This analysis included 4050 ischaemic stroke cases and 5765 controls from six study populations of European ancestry; 47% of cases were young-onset stroke (age < 55 years). To quantify the heritability for stroke risk in these unrelated individuals, the pairwise genetic relatedness was estimated between individuals based on their whole-genome array data using a mixed linear model. Heritability was estimated separately for young-onset stroke and old-onset stroke (age >= 55 years). RESULTS: Heritabilities for young-onset stroke and old-onset stroke were estimated at 42% (+/- 8%, P < 0.001) and 34% (+/-10%, P < 0.001), respectively. CONCLUSIONS: Our data suggest that the genetic contribution to the risk of stroke may be higher in young-onset ischaemic stroke, although the difference was not statistically significant. 2015 EAN.

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