PubblicazioniPublications    
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   HomePubblicazioni
Pubblicazioni IGM

Tumor Necrosis Factor Related Apoptosis Inducing Ligand (Trail) in Endothelial Response to Biomechanical and Biochemical Stresses in Arteries.

Autori

D'Auria F, Centurione L, Centurione MA, Angelini A, Di Pietro R.

Riferimenti

JOURNAL OF CELLULAR BIOCHEMISTRY 116(11) 2427-2434, 2015

Autori CNR

CENTURIONE

Moduli

Abstract

Shear stress is determined by three physical components described in a famous triad: blood flow, blood viscosity and vessel geometry. Through the direct action on endothelium, shear stress is able to radically interfere with endothelial properties and the physiology of the vascular wall. Endothelial cells (ECs) have also to sustain biochemical stresses represented by chemokines, growth factors, cytokines, complement, hormones, nitric oxide (NO), oxygen and reactive oxygen species (ROS). Many growth factors, cytokines, chemokines, hormones, and chemical substances, like NO, act and regulate endothelium functions and homeostasis. Among these cytokines Tumor Necrosis Factor Related Apoptosis Inducing Ligand (TRAIL) has been assigned a regulatory role in ECs physiology and physiopathology. Thus, the aim of this review is to provide a general overview of the endothelial response pathways after different types of biomechanical and biochemical stress in in vitro models and to analyze the crucial role of TRAIL under pathological conditions of the cardiocirculatory system like atherosclerosis, coronary artery disease, and diabetes. J. Cell. Biochem. 116: 2427-2434, 2015. 2015 Wiley Periodicals, Inc. 2015 Wiley Periodicals, Inc.

Link all articolo

http://onlinelibrary.wiley.com/doi/10.1002/jcb.25223/abstract

Parole Chiave

Note

Indietro


Copyright © 2014 Home