PubblicazioniPublications    
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   HomePubblicazioni
Pubblicazioni IGM

Molecular mechanisms of etoposide.

Autori

Montecucco A, Zanetta F, Biamonti G.

Riferimenti

EXCLI JOURNAL 14 95-108, 2015

Autori CNR

BIAMONTI, MONTECUCCO

Moduli

Abstract

Etoposide derives from podophyllotoxin, a toxin found in the American Mayapple. It was first synthesized in 1966 and approved for cancer therapy in 1983 by the U.S. Food and Drug Administration (Hande, 1998). Starting from 1980s several studies demonstrated that etoposide targets DNA topoisomerase II activities thus leading to the production of DNA breaks and eliciting a response that affects several aspects of cell metabolisms. In this review we will focus on molecular mechanisms that account for the biological effect of etoposide.

Link all articolo

http://www.excli.de/vol14/Montecucco_19012015_proof.pdf

Parole Chiave

Note

Indietro


Copyright © 2014 Home