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Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression.

Autori

Nahta R, Al-Mulla F, Al-Temaimi R, Amedei A, Andrade-Vieira R, Bay S, G Brown D, Calaf GM, Castellino RC, Cohen-Solal KA, Colacci A, Cruickshanks N, Dent P, Di Fiore R, Forte S, Goldberg GS, Hamid RA, Krishnan H, Laird DW, Lasfar A, Marignani PA, Memeo L, Mondello C, Naus CC, Ponce-Cusi R, Raju J, Roy D, Roy R, P Ryan E, Salem HK, Scovassi AI, Singh N, Vaccari M, Vento R, Vondracek J, Wade M, Woodrick J, Bisson WH.

Riferimenti

CARCINOGENESIS 36(Suppl 1) S2-S18, 2015

Autori CNR

MONDELLO, SCOVASSI

Moduli

Abstract

As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth factor-beta, gap junctions and contact inhibition. We discuss the effects of selected environmental chemicals on these mechanisms of growth inhibition and cross-reference the effects of these chemicals in other classical cancer hallmarks. The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Link all articolo

http://carcin.oxfordjournals.org/content/36/Suppl_1/S2.long

Parole Chiave

Note

Indietro


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