PubblicazioniPublications    
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
   HomePubblicazioni
Pubblicazioni IGM

Solution and Solid-State Analysis of Binding of 13-Substituted Berberine Analogues to Human Telomeric G-quadruplexes.

Autori

Ferraroni M, Bazzicalupi C, Papi F, Fiorillo G, Guaman-Ortiz LM, Nocentini A, Scovassi AI, Lombardi P, Gratteri P.

Riferimenti

CHEMiSTRY, AN ASIAN JOURNAL 11(7) 1107-1115, 2016

Autori CNR

SCOVASSI

Moduli

Abstract

The interaction between 13-phenylalkyl and 13-diphenylalkyl berberine derivatives (NAX) and human telomeric DNA G4 structures has been investigated by both spectroscopic and crystallographic methods. NAX042 and NAX053 are the best compounds improving the performance of the natural precursor berberine. This finding is in agreement with the X-ray diffraction result for the NAX053-Tel12 adduct, showing the ligand which interacts via pi-stacking, sandwiched at the interface of two symmetry-related quadruplex units, with its benzhydryl group contributing to the overall stability of the adduct by means of additional pi-stacking interactions with the DNA residues. The berberine derivatives were also investigated for their cytotoxic activity towards a panel of human cancer cell lines. Compounds NAX042 and NAX053 affect the viability of cancer cell lines in a dose-dependent manner. 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Link all articolo

http://onlinelibrary.wiley.com/doi/10.1002/asia.201600116/abstract;jsessionid=41A7EB754351C529E5530508A971084B.f04t01

Parole Chiave

Note

10.1002/asia.201600116

Indietro


Copyright © 2014 Home