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Telomere and telomerase stability in human diseases and cancer.

Autori

Chiodi I, Mondello C

Riferimenti

FRONTIERS IN BIOSCIENCE 21 203-224, 2016

Autori CNR

CHIODI, MONDELLO

Moduli

Abstract

Telomeres are the nucleoprotein structures at the end of linear eukaryotic chromosomes required for genome stability. Telomerase is the specialized enzyme deputed to their elongation. Maintenance of a proper telomere structure, an accurate regulation of telomerase biogenesis and activity, as well as a correct telomere-telomerase interaction and a faithful telomeric DNA replication are all processes that a cell has to precisely control to safeguard its functionality. Here, we review key factors that play a role in the development of these processes and their relationship with human health.

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Parole Chiave

Note

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