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Genetic variants linked to education predict longevity.

Autori

Marioni RE, ....., Biino G......, et al.

Riferimenti

PNAS 113(47) 13366-13371, 2016

Autori CNR

BIINO

Moduli

Abstract

Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = _17,000; UK Biobank, n = _115,000; and the Estonian Biobank, n = _6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members' polygenic profile score for education to predict their parents' longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with _2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and _2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.

Link all articolo

http://www.pnas.org/content/early/2016/10/25/1605334113.long

Parole Chiave

Note

10.1073/pnas.1605334113

Indietro


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