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Express or Repress? The Transcriptional Dilemma of Damaged Chromatin.

Autori

Capozzo I, Iannelli F, Francia S, d'Adda di Fagagna F.

Riferimenti

FEBS journal 284(14) 2133-2147, 2017

Autori CNR

D'ADDA, FRANCIA

Moduli

Abstract

The fine modulation of transcriptional activity around DNA lesions is essential to carefully regulate the crosstalk between transcription, the DNA damage response, and DNA repair, particularly when the lesion occurs next to, or within, actively transcribed genes. Recently, several studies have been carried out to investigate how DNA lesions have an impact on local transcription, but the emerging model remains incomplete. Transcription of genes around damaged DNA is actively down-regulated by the DNA damage response through different mechanisms, which appear specific to the chromatin context, the type of DNA damage or its complexity. Intriguingly, emerging evidence also indicates that transcription of non-coding RNAs (ncRNAs) is induced at sites of DNA damage, producing small ncRNAs that are, in turn, required for a full DDR activation. We discuss here these recent findings, highlighting the major unresolved questions in the field, and propose ways to reconcile these apparently contradictory observations. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Link all articolo

http://onlinelibrary.wiley.com/doi/10.1111/febs.14048/abstract

Parole Chiave

Note

10.1111/febs.14048

Indietro


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