Fabrizio d’Adda di Fagagna

Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”

Via Abbiategrasso, 207 – 27100 PAVIA
tel: +39 0382 546361
fax: +39 0382 546370

E-mail: fabrizio.dadda@igm.cnr.it

 


Pubblicazioni Recenti

2021

Mentegari E; Bertoletti F; Kissova M; Zucca E; Galli S; Tagliavini G; Garbelli A; Maffia A; Bione S; Ferrari E; d'Adda di Fagagna F; Francia S; Sabbioneda S; Chen LY; Lingner J; Bergoglio V; Hoffmann JS; Hubscher U; Crespan E; Maga G

A Role for Human DNA Polymerase lambda in Alternative Lengthening of Telomeres Journal Article

In: International journal of molecular sciences, 22 (5), pp. 2365, 2021.

Abstract | Links | BibTeX

Di Micco R; Krizhanovsky V; Baker D; d'Adda di Fagagna F

Cellular senescence in ageing: from mechanisms to therapeutic opportunities Journal Article

In: Nature reviews. Molecular cell biology, 22 (2), pp. 75-95, 2021.

Abstract | Links | BibTeX

Sepe S; Rossiello F; Cancila V; Iannelli F; Matti V; Cicio G; Cabrini M; Marinelli E; Alabi BR; di Lillo A; Di Napoli A; Shay JW; Tripodo C; d'Adda di Fagagna F

DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging. Journal Article Forthcoming

In: EMBO Reports, Forthcoming.

Abstract | Links | BibTeX

Pessina F; Gioia U; Brandi O; Farina S; Ceccon M; Francia S; d'Adda di Fagagna F

DNA Damage Triggers a New Phase in Neurodegeneration Journal Article

In: Trends in genetics , 37 (4), pp. 337-354, 2021.

Abstract | Links | BibTeX

Cabrini M; Roncador M; Galbiati A; Cipolla L; Maffia A; Iannelli F; Sabbioneda S; d'Adda di Fagagna F; Francia S

DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end-joining Journal Article

In: Journal of cell science, 134 (6), pp. jcs249706, 2021.

Abstract | Links | BibTeX

Sharma S; Anand R; Zhang X; Francia S; Michelini F; Galbiati A; Williams H; Ronato DA; Masson JY; Rothenberg E; Cejka P; d'Adda di Fagagna F

MRE11-RAD50-NBS1 Complex Is Sufficient to Promote Transcription by RNA Polymerase II at Double-Strand Breaks by Melting DNA Ends. Journal Article

In: Cell reports, 34 (1), pp. 108565, 2021.

Abstract | Links | BibTeX

Uryga AK; Grootaert MOJ; Garrido AM; Oc S; Foote K; Chappell J; Finigan A; Rossiello F; d'Adda di Fagagna F; Aravani D; Jorgensen HF; Bennett MR

Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury Journal Article

In: Communications biology, 4 (1), pp. 611, 2021.

Abstract | Links | BibTeX

2020

Rosso I; d'Adda di Fagagna F

Detection of Telomeric DNA: RNA Hybrids Using TeloDRIP-qPCR. Journal Article

In: International journal of molecular sciences, 21 (24), pp. 9774, 2020.

Abstract | Links | BibTeX

Aguado J; d'Adda di Fagagna F; Wolvetang E

Telomere transcription in ageing Journal Article

In: Ageing research reviews, 62 , pp. 101115, 2020.

Abstract | Links | BibTeX

2019

Pessina F; Giavazzi F; Yin Y; Gioia U; Vitelli V; Galbiati A; Barozzi S; Garre M; Oldani A; Flaus A; Cerbino R; Parazzoli D; Rothenberg E; d'Adda di Fagagna F

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors. Journal Article

In: Nature cell biology, 21 (10), pp. 1286-1299, 2019.

Abstract | Links | BibTeX

Aguado J; Sola-Carvajal A; Cancila V; Revêchon G; Ong PF; Jones-Weinert CW; Wallén Arzt E; Lattanzi G; Dreesen O; Tripodo C; Rossiello F; Eriksson M; d'Adda di Fagagna F

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome. Journal Article

In: Nature Communications, 10 (1), pp. 4990, 2019.

Abstract | Links | BibTeX

Gioia U; Francia S; Cabrini M; Brambillasca S; Michelini F; Jones-Weinert CW; d'Adda di Fagagna F

Pharmacological boost of DNA damage response and repair by enhanced biogenesis of DNA damage response RNAs. Journal Article

In: Scientific reports, 9 (1), pp. 6460, 2019.

Abstract | Links | BibTeX

Michelini F; Rossiello F; d'Adda di Fagagna F; Francia S

RNase A treatment and reconstitution with DNA damage response RNA in living cells as a tool to study the role of non-coding RNA in the formation of DNA damage response foci. Journal Article

In: Nature protocols, 14 (5), pp. 1489-1508, 2019.

Abstract | Links | BibTeX

2018

D'Alessandro G; Whelan DR; Howard SM; Vitelli V; Renaudin X; Adamowicz M; Iannelli F; Jones-Weinert CW; Lee M; Matti V; Lee WTC; Morten MJ; Venkitaraman AR; Cejka P; Rothenberg E; d'Adda di Fagagna F

BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment. Journal Article

In: Nature Communications, 9 (1), pp. 5376, 2018.

Abstract | Links | BibTeX

Galbiati A; d'Adda di Fagagna F

DNA Damage In Situ Ligation Followed by Proximity Ligation Assay (DI-PLA). Journal Article

In: Methods in Molecular Biology - Cellular Senescence Demaria M (eds), 1896 , pp. 11-20, 2018.

Abstract | Links | BibTeX

Michelini F; Jalihal AP; Francia S; Meers C; Neeb ZT; Rossiello F; Gioia U; Aguado J; Jones-Weinert C; Luke B; Biamonti G; Nowacki M; Storici F; Carninci P; Walter NG; d'Adda di Fagagna F

From "Cellular" RNA to "Smart" RNA: Multiple Roles of RNA in Genome Stability and Beyond. Journal Article

In: Chemical reviews, 118 (8), pp. 4365-4403, 2018.

Abstract | Links | BibTeX

Adamowicz M; d'Adda di Fagagna F; Vermezovic J

NOTCH1 modulates activity of DNA-PKcs. Journal Article

In: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 808 , pp. 20-27, 2018.

Abstract | Links | BibTeX

Nguyen Q; Aguado J; Iannelli F; Suzuki AM; Rossiello F; d'Adda di Fagagna F; Carninci P

Target-enrichment sequencing for detailed characterization of small RNAs. Journal Article

In: Nature Protocols, 13 , pp. 768-786, 2018.

Abstract | Links | BibTeX

2017

Iannelli F; Galbiati A; Capozzo I; Nguyen Q; Magnuson B; Michelini F; D'Alessandro G; Cabrini M; Roncador M; Francia S; Crosetto N; Ljungman M; Carninci P; d'Adda di Fagagna F

A damaged genome’s transcriptional landscape through multilayered expression profiling around in situ-mapped DNA double-strand breaks Journal Article

In: Nature Communications, 8 , pp. 15656, 2017.

Abstract | Links | BibTeX

Galbiati A; Beausejour C; d'Adda di Fagagna F

A novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues. Journal Article

In: Aging Cell, 16 (2), pp. 422-427, 2017.

Abstract | Links | BibTeX

Michelini F; Pitchiaya S; Vitelli V; Sharma S; Gioia U; Pessina F; Cabrini M; Wang Y; Capozzo I; Iannelli F; Matti V; Francia S; Shivashankar GV; Walter NG; d'Adda di Fagagna F

Comparison of computational methods for Hi-C data analysis. Journal Article

In: Nature cell biology, 19 (2), pp. 1400-1410, 2017.

Abstract | Links | BibTeX

Michelini F; Pitchiaya S; Vitelli V; Sharma S; Gioia U; Pessina F; Cabrini M; Wang Y; Capozzo I; Iannelli F; Matti V; Francia S; Shivashankar GV; Walter NG; d'Adda di Fagagna F

Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks. Journal Article

In: Nature cell biology, 19 (2), pp. 1400-1410, 2017.

Abstract | Links | BibTeX

Rossiello F; Aguado J; Sepe S; Iannelli F; Nguyen Q; Pitchiaya S; Carninci P; d'Adda di Fagagna F

DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs. Journal Article

In: Nature Communications, 8 , pp. 13980, 2017.

Abstract | Links | BibTeX

Capozzo I; Iannelli F; Francia S; d'Adda di Fagagna F

Express or Repress? The Transcriptional Dilemma of Damaged Chromatin. Journal Article

In: FEBS journal, 284 (14), pp. 2133-2147, 2017.

Abstract | Links | BibTeX

Vitelli V; Galbiati A; Iannelli F; Pessina F; Sharma S; d'Adda di Fagagna F

Recent Advancements in DNA Damage-Transcription Crosstalk and High-Resolution Mapping of DNA Breaks. Journal Article

In: Annual review of genomics and human genetics, 18 , pp. 87-113, 2017.

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Rohban S; Cerutti A; Morelli MJ; d'Adda di Fagagna F; Campaner S

The cohesin complex prevents Myc-induced replication stress. Journal Article

In: Cell Death and Disease, 8 , pp. e2956, 2017.

Abstract | Links | BibTeX

D'Alessandro G; d'Adda di Fagagna F

Transcription and DNA Damage: Holding Hands or Crossing Swords? First dual AK/GSK-3beta inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents. Journal Article

In: Journal of Molecular Biology, 429 (21), pp. 3215-3229, 2017.

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Venkata Narayanan I; Paulsen MT; Bedi K; Berg N; Ljungman EA; Francia S; Veloso A; Magnuson B; d'Adda di Fagagna F; Wilson TE; Ljungman M

Transcriptional and post-transcriptional regulation of the ionizing radiation response by ATM and p53. Journal Article

In: Scientific reports, 7 (1), pp. 43598, 2017.

Abstract | Links | BibTeX

2016

Francia S; Cabrini M; Matti V; Oldani A; d'Adda di Fagagna F

DICER, DROSHA and DNA damage response RNAs are necessary for the secondary recruitment of DNA damage response factors. Journal Article

In: Journal of Cell Science, 129 , pp. 1468-1476, 2016.

Abstract | Links | BibTeX

Adamowicz M; Vermezovic J; d'Adda di Fagagna F

NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex. Journal Article

In: Cell Reports, 16 (8), pp. 2068-2076, 2016.

Abstract | Links | BibTeX

2015

Gioia U; d'Adda di Fagagna F

Human nuclear ARGONAUTE 2 interacts in vivo only with small RNAs and not with DNA. Journal Article

In: Cell Cycle, 14 (13), pp. 2001-2002, 2015.

Abstract | Links | BibTeX

Vermezovic J; Adamowicz M; Santarpia L; Rustighi A; Forcato M; Lucano C; Massimiliano L; Costanzo V; Bicciato S; Del Sal G; d'Adda di Fagagna F

Notch is a direct negative regulator of the DNA-damage response. Journal Article

In: Nature Structural & Molecular Biology, 22 (5), pp. 417-424, 2015.

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Manfrini N; Clerici M; Wery M; Colombo CV; Descrimes M; Morillon A; d'Adda di Fagagna F; Longhese MP

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae. Journal Article

In: Elife, 4 , 2015.

Abstract | Links | BibTeX

Manfrini N; Trovesi C; Wery M; Martina M; Cesena D; Descrimes M; Morillon A; d'Adda di Fagagna F; Longhese MP

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA. Journal Article

In: Embo Reports, 16 (2), pp. 221-231, 2015.

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Meena JK; Cerutti A; Beichler C; Morita Y; Bruhn C; Kumar M; Kraus JM; Speicher MR; Wang ZQ; Kestler HA; d'Adda di Fagagna F; Günes C; Rudolph KL

Telomerase abrogates aneuploidy-induced telomere replication stress, senescence and cell depletion. Journal Article

In: Embo Journal, 34 (10), pp. 1371-1384, 2015.

Abstract | Links | BibTeX