Camilla Evangelisti


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 2091581

E-mail: camilla.evangelisti@area.cnr.bo.it

Curriculum Vitae – Download

Elenco completo delle pubblicazioni – Download

Attività di ricerca

  • Fenomeni di TRASDUZIONE DEL SEGNALE basati sui polifosfoinositidi e sulla protein chinasi C a livello nucleare durante la proliferazione ed il differenziamento cellulare.
  • Analisi della TRASDUZIONE DEL SEGNALE di isoforme della diacilglicerolo chinasi a livello nucleare in seguito a stimoli proliferativi e differenziativi in cellule mioblastiche.
  • Vie di TRASDUZIONE DEL SEGNALE imperniate su fosfoinositide 3-chinasi/Akt/mTOR e Raf/MEK/Erk nella farmacoresistenza di cellule leucemiche umane e murine.
  • Coinvolgimento di vie di TRASDUZIONE DEL SEGNALE (TGFbeta, PI3K/Akt/mTOR e Raf/MEK/Erk) in laminopatie.
  • Fenomeni di TRASDUZIONE DEL SEGNALE e MECCANOSIGNALING nello studio dell’unità muscolo-tendinea e malattie associate come la distrofia muscolare e le tendinopatie legate all’età
  • Studio delle lamine nei tumori ossei

Gruppo di ricerca

Francesca Chiarini

Elisabetta Mattioli

Vittoria Cenni

Patrizia Sabatelli

Giovanna Lattanzi

 


Pubblicazioni Recenti

2021

Martelli AM; Evangelisti C; Paganelli F; Chiarini F; McCubrey JA

GSK-3: a multifaceted player in acute leukemias Journal Article Forthcoming

Leukemia, Forthcoming.

Abstract | Links | BibTeX

2020

Ratti S; Lonetti A; Follo MY; Paganelli F; Martelli AM; Chiarini F; Evangelisti C

B-ALL Complexity: Is Targeted Therapy Still A Valuable Approach for Pediatric Patients? Journal Article

Cancers, 12 (12), pp. E3498, 2020.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Paganelli F; Marmiroli S; Martelli AM

Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer. Journal Article

Biochimica et biophysica acta. Molecular cell research, 1867 (4), pp. 118635, 2020.

Abstract | Links | BibTeX

Evangelisti C; Paganelli F; Giuntini G; Mattioli E; Cappellini A; Ramazzotti G; Faenza I; Maltarello MC; Martelli AM; Scotlandi K; Chiarini F; Lattanzi G

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells Journal Article

Cells, 9 (3), pp. 774, 2020.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Cappellini A; Paganelli F; Fini M; Santi S; Martelli AM; Neri LM; Evangelisti C

Targeting Wnt/beta-catenin and PI3K/Akt/mTOR pathways in T-cell acute lymphoblastic leukemia. Journal Article

Journal of cellular physiology, 235 (6), pp. 5413-5428, 2020.

Abstract | Links | BibTeX

Chiarini F; Paganelli F; Martelli AM; Evangelisti C

The Role Played by Wnt/beta-Catenin Signaling Pathway in Acute Lymphoblastic Leukemia. Journal Article

International journal of molecular sciences, 21 (3), pp. e1098, 2020.

Abstract | Links | BibTeX

Martelli AM; Paganelli F; Chiarini F; Evangelisti C; McCubrey JA

The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias. Journal Article

Cancers, 12 (2), pp. e333, 2020.

Abstract | Links | BibTeX

2019

Chiarini F; Evangelisti C; Lattanzi G; McCubrey JA; Martelli AM

Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells. Journal Article

Biochimica et biophysica acta. Molecular cell research, 1866 (8), pp. 1322-1337, 2019.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Paganelli F; Marmiroli S; Martelli AM

Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer. Journal Article

Biochimica et biophysica acta. Molecular cell research, 1867 (4), pp. 118635, 2019.

Abstract | Links | BibTeX

Paganelli F; Lonetti A; Anselmi L; Martelli AM; Evangelisti C; Chiarini F

New advances in targeting aberrant signaling pathways in T-cell acute lymphoblastic leukemia. Journal Article

Advances in biological regulation, 74 , pp. 100649, 2019.

Abstract | Links | BibTeX

Chiarini F; Evangelisti C; Cenni V; Fazio A; Paganelli F; Martelli AM; Lattanzi G

The Cutting Edge: The Role of mTOR Signaling in Laminopathies. Journal Article

International journal of molecular sciences, 20 (4), pp. E847, 2019.

Abstract | Links | BibTeX

2018

Bernasconi P; Carboni N; Ricci G; Siciliano G; Politano L; Maggi L; Mongini T; Vercelli L; Rodolico C; Biagini E; Boriani G; Ruggiero L; Santoro L; Schena E; Prencipe S; Evangelisti C; Pegoraro E; Morandi L; Columbaro M; Lanzuolo C; Sabatelli P; Cavalcante P; Cappelletti C; Bonne G; Muchir A; Lattanzi G

Elevated TGF beta2 serum levels in Emery-Dreifuss muscular dystrophy: implications for myocyte and tenocyte differentiation and fibrogenic processes. Journal Article

Nucleus, 25 (1), pp. 24, 2018.

Abstract | Links | BibTeX

Evangelisti C; Cappellini A; Oliveira M; Fragoso R; Barata JT; Bertaina A; Locatelli F; Simioni C; Neri LM; Chiarini F; Lonetti A; Buontempo F; Orsini E; Pession A; Manzoli L; Martelli AM; Evangelisti C

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia. Journal Article

Journal of cellular physiology, 233 (3), pp. 1796-1811, 2018.

Abstract | Links | BibTeX

Buontempo F; McCubrey JA; Orsini E; Ruzzene M; Cappellini A; Lonetti A; Evangelisti C; Chiarini F; Evangelisti C; Barata JT; Martelli AM

Therapeutic targeting of CK2 in acute and chronic leukemias. Journal Article

Leukemia, 32 (1), pp. 1-10, 2018.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; McCubrey JA; Martelli AM

Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update. Journal Article

International journal of molecular sciences, 19 (7), pp. pii: E1878, 2018.

Abstract | Links | BibTeX

2017

Ultimo S; Simioni C; Martelli AM; Zauli G; Evangelisti C; Celeghini C; McCubrey JA; Marisi G; Ulivi P; Capitani S; Neri LM

PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines. Journal Article

Oncotarget, 8 (14), pp. 23213-23227, 2017.

Abstract | Links | BibTeX

2016

Chiarini F; Lonetti A; Evangelisti C; Buontempo F; Orsini E; Evangelisti C; Cappellini A; Neri LM; McCubrey JA; Martelli AM

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting. Journal Article

Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research, 1863 (3), pp. 449-463, 2016.

Abstract | Links | BibTeX

Lonetti A; Cappellini A; Bertaina A; Locatelli F; Pession A; Buontempo F; Evangelisti C; Evangelisti C; Orsini E; Zambonin L; Neri LM; Martelli AM; Chiarini F

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway. Journal Article

Journal Of Hematology & Oncology , 9 (1), pp. 114, 2016.

Abstract | Links | BibTeX

Evangelisti C; Cenni V; Lattanzi G

Potential therapeutic effects of the mtor inhibitors for preventing ageing and progeria-related disorders. Journal Article

British Journal of Clinical Pharmacology (Literature Review), 82 (5), pp. 1229-1244, 2016.

Abstract | Links | BibTeX

Buontempo F; Orsini E; Lonetti A; Cappellini A; Chiarini F; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; Bertacchini J; Neri LM; McCubrey JA; Martelli AM

Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Journal Article

Oncotarget, 7 (2), pp. 1323-1340, 2016.

Abstract | Links | BibTeX

Evangelisti C; Evangelisti C; Buontempo F; Lonetti A; Orsini E; Chiarini F; Barata JT; Pyne S; Pyne NJ; Martelli AM

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. Journal Article

Leukemia, 30 (11), pp. 2142-2151, 2016.

Abstract | Links | BibTeX

2015

Evangelisti C; Evangelisti C; Chiarini F; Lonetti A; Buontempo F; Neri LM; McCubrey JA; Martelli AM

Autophagy in acute leukemias: A double-edged sword with important therapeutic implications Journal Article

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853 (1), pp. 14-26, 2015.

Abstract | Links | BibTeX

Chiarini F; Evangelisti C; McCubrey JA; Martelli AM

Current treatment strategies for inhibiting mTOR in cancer Journal Article

Trends in Pharmacological Sciences, 36 (2), 2015.

Abstract | Links | BibTeX

Evangelisti C; Bernasconi P; Cavalcante P; Cappelletti C; D'Apice MR; Sbraccia P; Novelli G; Prencipe S; Lemma S; Baldini N; Avnet S; Squarzoni S; Martelli AM; Lattanzi G

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins. Journal Article

Oncotarget, 6 (10), pp. 7424-7437, 2015.

Abstract | Links | BibTeX

Lonetti A; Cappellini A; Spartà AM; Chiarini F; Buontempo F; Evangelisti C; Evangelisti C; Orsini E; McCubrey JA; Martelli AM

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors. Journal Article

Oncotarget, 6 (12), pp. 10399-10414, 2015.

Abstract | Links | BibTeX

2014

Evangelisti C; Evangelisti C; Teti G; Chiarini F; Falconi M; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Beak DJ; Bittman R; Pyne S; Pyne NJ; Martelli AM

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; Indications for novel therapeutics Journal Article

Oncotarget, 5 , pp. 7886-7901, 2014, ISSN: 1949-2553.

Abstract | Links | BibTeX

Buontempo F; Orsini E; Martins LR; Antunes I; Lonetti A; Chiarini F; Tabellini G; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Cappellini A; Barata JT; Martelli AM

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: Targeting the unfolded protein response signaling Journal Article

Leukemia (Basingstoke, Online), 28 , pp. 543-553, 2014, ISSN: 1476-5551.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Lonetti A; Buontempo F; Bressanin D; Cappellini A; Orsini E; McCubrey JA; Martelli AM; Evangelisti C

Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (Review) Journal Article

International journal of oncology, 45 , pp. 909–918, 2014, ISSN: 1019-6439.

Abstract | Links | BibTeX

Bressanin D; Chiarini F; Lonetti A; Cappellini A; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Martelli AM; Sparta AM

Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia Journal Article

Cell cycle (Georget. Tex.), 13 , pp. 2237–2247, 2014, ISSN: 1538-4101.

Abstract | Links | BibTeX