Giovanna Lattanzi


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 6366857
Fax: +39 051 4689922

E-mail: giovanna.lattanzi@cnr.it

Competenze:         

Biologia cellulare e molecolare del nucleo e dell’involucro nucleare.

Differenziamento muscolare, osseo, adipocitario. Colture cellulari stabili e primarie.

Espressione di proteine wild-type e mutate in cellule stabili e in colture primarie.

Microscopia ottica e immunofluorescenza.

Descrizione attività:

Studio delle lamine e dell’involucro nucleare. Organizzazione funzionale del nucleo e della cromatina.

Studio delle laminopatie: distrofie muscolari e lipodistrofie da mutazioni di proteine dell’involucro nucleare (distrofie di Emery-Dreifuss, Familial partial lipodystrophy),  laminopatie progeroidi (Progeria di Hutchinson-Gilford, Displasia mandibuloacrale) e sindromiche (Restricitve Dermopathy).  

Studio delle implicazioni delle proteine dell’involucro nucleare nel differenziamento muscolare, adipocitario e osseo


Pubblicazioni Recenti

2021

Abrusci G; Tarenzi T; Sturlese M; Giachin G; Battistutta R; Lattanzi G

Comparative Molecular Dynamics Investigation of the Electromotile Hearing Protein Prestin Journal Article

In: International journal of molecular sciences, 22 (15), pp. 8318, 2021.

Abstract | Links | BibTeX

Piazzi M; Kojic S; Capanni C; Stamenkovic N; Bavelloni A; Marin O; Lattanzi G; Blalock WL; Cenni V

Ectopic Expression of Ankrd2 Affects Proliferation, Motility and Clonogenic Potential of Human Osteosarcoma Cells. Journal Article

In: Cancers (Basel), 13 (2), pp. e174, 2021.

Abstract | Links | BibTeX

Squarzoni S; Schena E; Sabatelli P; Mattioli E; Capanni C; Cenni V; D'Apice MR; Andrenacci D; Sarli G; Pellegrino V; Festa A; Baruffaldi F and Storci G; Bonafè M; Barboni C; Sanapo M; Zaghini A; Lattanzi G

Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice. Journal Article

In: Aging Cell, 20 (1), pp. e13285, 2021.

Abstract | Links | BibTeX

Vasconcelos MH; Alcaro S; Arechavala-Gomeza V; Baumbach J; Borges F; Brevini TAL; Rivas JL; Devaux Y; Hozak P; Keinanen-Toivola MM; Lattanzi G; Mohr T; Murovska M; Prusty BK; Quinlan RA; Perez-Sala D; Scheibenbogen C; Schmidt HHHW; Silveira I; Tieri P; Tolios A; Riganti C

Joining European Scientific Forces to Face Pandemics. Journal Article

In: Trends in microbiology, 29 (2), pp. 92-97, 2021.

Abstract | Links | BibTeX

Costa R; Rodia MT; Zini N; Pegoraro V; Marozzo R; Capanni C; Angelini C; Lattanzi G; Santi S; Cenacchi G

Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Journal Article

In: Molecular and cellular biochemistry, 476 (4), pp. 1797-1811, 2021.

Abstract | Links | BibTeX

Maggi L; Mavroidis M; Psarras S; Capetanaki Y; Lattanzi G

Skeletal and Cardiac Muscle Disorders Caused by Mutations in Genes Encoding Intermediate Filament Proteins Journal Article

In: International journal of molecular sciences, 22 (8), pp. 4256, 2021.

Abstract | Links | BibTeX

2020

Cappelletti C; Tramacere I; Cavalcante P; Schena E; Politano L; Carboni N; Gambineri A; D'Amico A; Ruggiero L; Ricci G; Siciliano G; Boriani G; Mongini TE; Vercelli L; Biagini E; Ziacchi M; D'Apice MR; Lattanzi G; Mantegazza R; Maggi L; Bernasconi P

Cytokine Profile in Striated Muscle Laminopathies: New Promising Biomarkers for Disease Prediction Journal Article

In: Cells, 9 (6), pp. 1532, 2020.

Abstract | Links | BibTeX

Cenni V; Squarzoni S; Loi M; Mattioli E; Lattanzi G; Capanni C

Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization Journal Article

In: Cells, 9 (6), pp. 1415, 2020.

Abstract | Links | BibTeX

von Schnurbein J; Adams C; Akinci B; Ceccarini G; D'Apice MR; Gambineri A; Hennekam RCM; Jeru I; Lattanzi G; Miehle K; Nagel G; Novelli G; Santini F; Santos Silva E; Savage DB; Sbraccia P; Schaaf J; Sorkina E; Tanteles G; Vantyghem MC; Vatier C; Vigouroux C; Vorona E; Araújo-Vilar D; Wabitsch M

European lipodystrophy registry: background and structure. Journal Article

In: Orphanet journal of rare diseases, 15 (1), pp. 17, 2020.

Abstract | Links | BibTeX

von Schnurbein J; Adams C; Akinci B; Ceccarini G; D'Apice MR; Gambineri A; Hennekam RCM; Jeru I; Lattanzi G; Miehle K; Nagel G; Novelli G; Santini F; Santos Silva E; Savage DB; Sbraccia P; Schaaf J; Sorkina E; Tanteles G; Vantyghem MC; Vatier C; Vigouroux C; Vorona E; Araujo-Vilar D; Wabitsch M

European lipodystrophy registry: background and structure. Journal Article

In: Orphanet journal of rare diseases, 15 (1), pp. 17, 2020.

Abstract | Links | BibTeX

Vasconcelos MH; Alcaro S; Arechavala-Gomeza V; Baumbach J; Borges F; Brevini TAL; Rivas JL; Devaux Y; Hozak P; Keinanen-Toivola MM; Lattanzi G; Mohr T; Murovska M; Prusty BK; Quinlan RA; Perez-Sala D; Scheibenbogen C; Schmidt HHHW; Silveira I; Tieri P; Tolios A; Riganti C

Joining European Scientific Forces to Face Pandemics. Journal Article

In: Trends in microbiology, S0966-842X(20) , pp. 30270-30275, 2020.

Abstract | Links | BibTeX

Evangelisti C; Paganelli F; Giuntini G; Mattioli E; Cappellini A; Ramazzotti G; Faenza I; Maltarello MC; Martelli AM; Scotlandi K; Chiarini F; Lattanzi G

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells Journal Article

In: Cells, 9 (3), pp. 774, 2020.

Abstract | Links | BibTeX

Cenni V; Capanni C; Mattioli E; Schena E; Squarzoni S; Bacalini MG; Garagnani P; Salvioli S; Franceschi C; Lattanzi G

Lamin A Involvement in Ageing Processes Journal Article

In: Ageing research reviews, 62 , pp. 101073, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

In: Experimental gerontology, 130 , pp. 110784, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

In: Experimental gerontology, 130 , pp. 110784, 2020.

Abstract | Links | BibTeX

Santi S; Cenni V; Capanni C; Lattanzi G; Mattioli E

PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation Journal Article

In: Cells, 9 (7), pp. E1735, 2020.

Abstract | Links | BibTeX

Cavaliere V; Lattanzi G; Andrenacci D

Silencing of Euchromatic Transposable Elements as a Consequence of Nuclear Lamina Dysfunction. Journal Article

In: Cells, 9 (3), pp. e625, 2020.

Abstract | Links | BibTeX

Andrenacci D; Cavaliere V; Lattanzi G

The role of transposable elements activity in aging and their possible involvement in laminopathic diseases. Journal Article

In: Ageing research reviews, 57 , pp. 100995, 2020.

Abstract | Links | BibTeX

Costa R; Rodia MT; Vianello S; Santi S; Lattanzi G; Angelini C; Pegoraro E; Cenacchi G

Transportin 3 (TNPO3) and related proteins in limb girdle muscular dystrophy D2 muscle biopsies: A morphological study and pathogenetic hypothesis Journal Article

In: Neuromuscular disorders, 2020.

Abstract | Links | BibTeX

2019

Chiarini F; Evangelisti C; Lattanzi G; McCubrey JA; Martelli AM

Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells. Journal Article

In: Biochimica et biophysica acta. Molecular cell research, 1866 (8), pp. 1322-1337, 2019.

Abstract | Links | BibTeX

Pellegrini C; Columbaro M; Schena E; Prencipe S; Andrenacci D; Iozzo P; Angela Guzzardi M; Capanni C; Mattioli E; Loi M; Araujo-Vilar D; Squarzoni S; Cinti S; Morselli P; Giorgetti A; Zanotti L; Gambineri A; Lattanzi G

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Journal Article

In: Experimental & molecular medicine., 51 (8), pp. 89, 2019.

Abstract | Links | BibTeX

Cenni V; Kojic S; Capanni C; Faulkner G; Lattanzi G

Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies. Journal Article

In: Oxidative medicine and cellular longevity, 2019 , pp. 7318796, 2019, (Review).

Abstract | Links | BibTeX

Ditaranto R; Boriani G; Biffi M; Lorenzini M; Graziosi M; Ziacchi M; Pasquale F; Vitale G; Berardini A; Rinaldi R; Lattanzi G; Potena L; Martin Suarez S; Bacchi Reggiani ML; Rapezzi C; Biagini E

Differences in cardiac phenotype and natural history of laminopathies with and without neuromuscular onset. Journal Article

In: Orphanet journal of rare diseases, 14 (1), pp. 263, 2019.

Abstract | Links | BibTeX

Aguado J; Sola-Carvajal A; Cancila V; Revêchon G; Ong PF; Jones-Weinert CW; Wallén Arzt E; Lattanzi G; Dreesen O; Tripodo C; Rossiello F; Eriksson M; d'Adda di Fagagna F

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome. Journal Article

In: Nature Communications, 10 (1), pp. 4990, 2019.

Abstract | Links | BibTeX

Mattioli E; Andrenacci D; Mai A; Valente S; Robijns J; De Vos WH; Capanni C; Lattanzi G

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C - Histone Deacetylase 2 Interaction in Human Cells. Journal Article

In: Frontiers in cell and developmental biology, 7 , pp. 6, 2019.

Abstract | Links | BibTeX

Chiarini F; Evangelisti C; Cenni V; Fazio A; Paganelli F; Martelli AM; Lattanzi G

The Cutting Edge: The Role of mTOR Signaling in Laminopathies. Journal Article

In: International journal of molecular sciences, 20 (4), pp. E847, 2019.

Abstract | Links | BibTeX

2018

Mattioli E; Andrenacci D; Garofalo C; Prencipe S; Scotlandi K; Remondini D; Gentilini D; Di Blasio AM; Valente S; Scarano E; Cicchilitti L; Piaggio G; Mai A; Lattanzi G

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. Journal Article

In: Aging cell, 17 (5), pp. e1282, 2018.

Abstract | Links | BibTeX

Zironi I; Gavoci E; Lattanzi G; Virelli A; Amorini F; Remondini D; Castellani G

BK channel overexpression on plasma membrane of fibroblasts from Hutchinson-Gilford progeria syndrome. Journal Article

In: Aging (Albany, NY), 10 (11), pp. 3148-3160, 2018.

Abstract | Links | BibTeX

Boriani G; Biagini E; Ziacchi M; Malavasi VL; Vitolo M; Talarico M; Mauro E; Gorlato G; Lattanzi G

Cardiolaminopathies from bench to bedside: challenges in clinical decision-making with focus on arrhythmia-related outcomes. Journal Article

In: Nucleus, 9 (1), pp. 442-459, 2018.

Abstract | Links | BibTeX

Bernasconi P; Carboni N; Ricci G; Siciliano G; Politano L; Maggi L; Mongini T; Vercelli L; Rodolico C; Biagini E; Boriani G; Ruggiero L; Santoro L; Schena E; Prencipe S; Evangelisti C; Pegoraro E; Morandi L; Columbaro M; Lanzuolo C; Sabatelli P; Cavalcante P; Cappelletti C; Bonne G; Muchir A; Lattanzi G

Elevated TGF beta2 serum levels in Emery-Dreifuss muscular dystrophy: implications for myocyte and tenocyte differentiation and fibrogenic processes. Journal Article

In: Nucleus, 25 (1), pp. 24, 2018.

Abstract | Links | BibTeX

Lattanzi G; Maggi L; Araujo-Vilar D

Laminopathies. Journal Article

In: Nucleus, 9 (1), pp. 543-544, 2018.

Links | BibTeX

Gargiuli C; Schena E; Mattioli E; Columbaro M; D'Apice MR; Novelli G; Greggi T; Lattanzi G

Lamins and bone disorders: current understanding and perspectives. Journal Article

In: Oncotarget, 9 (32), pp. 22817-22831, 2018.

Abstract | Links | BibTeX

Cenni V; D'Apice MR; Garagnani P; Columbaro M; Novelli G; Franceschi C; Lattanzi G

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. Journal Article

In: Ageing research reviews, 42 , pp. 1-13, 2018.

Abstract | Links | BibTeX

Jiang Z; Cinti C; Taranta M; Mattioli E; Schena E; Singh S; Khurana R; Lattanzi G; Tsinoremas NF; Capobianco E

Network assessment of demethylation treatment in melanoma: Differential transcriptome-methylome and antigen profile signatures. Journal Article

In: Plos One, 13 (11), pp. e0206686, 2018.

Abstract | Links | BibTeX

Mattioli E; Columbaro M; Jafferali MH; Schena E; Hallberg E; Lattanzi G

Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy. Journal Article

In: Cells, 7 (10), pp. pii: E170, 2018.

Abstract | Links | BibTeX

2017

Angori S; Capanni C; Faulkner G; Bean C; Boriani G; Lattanzi G; Cenni V

Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular Response to Oxidative Stress. Journal Article

In: Cellular Physiology and Biochemistry, 42 , pp. 169-184, 2017.

Abstract | Links | BibTeX

Cenni V; D'Apice MR; Garagnani P; Columbaro M; Novelli G; Franceschi C; Lattanzi G

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. Journal Article

In: Ageing research reviews, 42 , pp. 1-13, 2017.

Abstract | Links | BibTeX

2016

Loi M; Cenni V; Duchi S; Squarzoni S; Lopez-Otin C; Foisner R; Lattanzi G; Capanni C

Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes. Journal Article

In: Oncotarget, 7 (13), pp. 15662-15677, 2016.

Abstract | Links | BibTeX

Bellotti C; Capanni C; Lattanzi G; Donati D; Lucarelli E; Duchi S

Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level. Journal Article

In: Springerplus, 5 (1), pp. 1427, 2016.

Abstract | Links | BibTeX

Evangelisti C; Cenni V; Lattanzi G

Potential therapeutic effects of the mtor inhibitors for preventing ageing and progeria-related disorders. Journal Article

In: British Journal of Clinical Pharmacology (Literature Review), 82 (5), pp. 1229-1244, 2016.

Abstract | Links | BibTeX

Burla R; Carcuro M; Torre ML; Fratini F; Crescenzi M; D'Apice MR; Spitalieri P; Raffa GD; Astrologo L; Lattanzi G; Cundari E; Raimondo D; Biroccio A; Gatti M; Saggio I

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Journal Article

In: Open Biology, 6 (8), pp. 160103, 2016.

Abstract | Links | BibTeX

2015

Pellegrini C; Columbaro M; Capanni C; D'Apice MR; Cavallo C; Murdocca M; Lattanzi G; Squarzoni S

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Journal Article

In: Oncotarget, 6 (30), pp. 29914-29928, 2015.

Abstract | Links | BibTeX

Lattanzi G

Chromatin dynamics and in vitro biomarkers in laminopathies: an overview Journal Article

In: Orphanet journal of rare diseases, 10 , 2015.

Links | BibTeX

Evangelisti C; Bernasconi P; Cavalcante P; Cappelletti C; D'Apice MR; Sbraccia P; Novelli G; Prencipe S; Lemma S; Baldini N; Avnet S; Squarzoni S; Martelli AM; Lattanzi G

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins. Journal Article

In: Oncotarget, 6 (10), pp. 7424-7437, 2015.

Abstract | Links | BibTeX

Di Pompo G; Salerno M; Rotili D; Valente S; Zwergel C; Avnet S; Lattanzi G; Baldini N; Mai A

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. Journal Article

In: Journal of Medicinal Chemistry, 58 (9), pp. 4073-4079, 2015.

Abstract | Links | BibTeX

Piva R; Lambertini E; Manferdini C; Capanni C; Penolazzi L; Gabusi E; Paolella F; Lolli A; Angelozzi M; Lattanzi G; Lisignoli G

Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes. Journal Article

In: Osteoarthritis and Cartilage, 23 (7), pp. 1226-1230, 2015.

Abstract | Links | BibTeX