Giovanna Lattanzi


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 6366394
Fax: +39 051 4689922

E-mail: lattanzi@area.bo.cnr.it

Competenze:         

Biologia cellulare e molecolare del nucleo e dell’involucro nucleare.

Differenziamento muscolare, osseo, adipocitario. Colture cellulari stabili e primarie.

Espressione di proteine wild-type e mutate in cellule stabili e in colture primarie.

Microscopia ottica e immunofluorescenza.


Descrizione attività:

Studio delle lamine e dell’involucro nucleare. Organizzazione funzionale del nucleo e della cromatina.

Studio delle laminopatie: distrofie muscolari e lipodistrofie da mutazioni di proteine dell’involucro nucleare (distrofie di Emery-Dreifuss, Familial partial lipodystrophy),  laminopatie progeroidi (Progeria di Hutchinson-Gilford, Displasia mandibuloacrale) e sindromiche (Restricitve Dermopathy).  

Studio delle implicazioni delle proteine dell’involucro nucleare nel differenziamento muscolare, adipocitario e osseo


Pubblicazioni Recenti

2021

Piazzi M; Kojic S; Capanni C; Stamenkovic N; Bavelloni A; Marin O; Lattanzi G; Blalock WL; Cenni V

Ectopic Expression of Ankrd2 Affects Proliferation, Motility and Clonogenic Potential of Human Osteosarcoma Cells. Journal Article

Cancers (Basel), 13 (2), pp. e174, 2021.

Abstract | Links | BibTeX

Squarzoni S; Schena E; Sabatelli P; Mattioli E; Capanni C; Cenni V; D'Apice MR; Andrenacci D; Sarli G; Pellegrino V; Festa A; Baruffaldi F and Storci G; Bonafè M; Barboni C; Sanapo M; Zaghini A; Lattanzi G

Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice. Journal Article

Aging Cell, 20 (1), pp. e13285, 2021.

Abstract | Links | BibTeX

Vasconcelos MH; Alcaro S; Arechavala-Gomeza V; Baumbach J; Borges F; Brevini TAL; Rivas JL; Devaux Y; Hozak P; Keinanen-Toivola MM; Lattanzi G; Mohr T; Murovska M; Prusty BK; Quinlan RA; Perez-Sala D; Scheibenbogen C; Schmidt HHHW; Silveira I; Tieri P; Tolios A; Riganti C

Joining European Scientific Forces to Face Pandemics. Journal Article

Trends in microbiology, 29 (2), pp. 92-97, 2021.

Abstract | Links | BibTeX

Costa R; Rodia MT; Zini N; Pegoraro V; Marozzo R; Capanni C; Angelini C; Lattanzi G; Santi S; Cenacchi G

Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Journal Article

Molecular and cellular biochemistry, 476 (4), pp. 1797-1811, 2021.

Abstract | Links | BibTeX

2020

Cappelletti C; Tramacere I; Cavalcante P; Schena E; Politano L; Carboni N; Gambineri A; D'Amico A; Ruggiero L; Ricci G; Siciliano G; Boriani G; Mongini TE; Vercelli L; Biagini E; Ziacchi M; D'Apice MR; Lattanzi G; Mantegazza R; Maggi L; Bernasconi P

Cytokine Profile in Striated Muscle Laminopathies: New Promising Biomarkers for Disease Prediction Journal Article

Cells, 9 (6), pp. 1532, 2020.

Abstract | Links | BibTeX

Cenni V; Squarzoni S; Loi M; Mattioli E; Lattanzi G; Capanni C

Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization Journal Article

Cells, 9 (6), pp. 1415, 2020.

Abstract | Links | BibTeX

von Schnurbein J; Adams C; Akinci B; Ceccarini G; D'Apice MR; Gambineri A; Hennekam RCM; Jeru I; Lattanzi G; Miehle K; Nagel G; Novelli G; Santini F; Santos Silva E; Savage DB; Sbraccia P; Schaaf J; Sorkina E; Tanteles G; Vantyghem MC; Vatier C; Vigouroux C; Vorona E; Araújo-Vilar D; Wabitsch M

European lipodystrophy registry: background and structure. Journal Article

Orphanet journal of rare diseases, 15 (1), pp. 17, 2020.

Abstract | Links | BibTeX

von Schnurbein J; Adams C; Akinci B; Ceccarini G; D'Apice MR; Gambineri A; Hennekam RCM; Jeru I; Lattanzi G; Miehle K; Nagel G; Novelli G; Santini F; Santos Silva E; Savage DB; Sbraccia P; Schaaf J; Sorkina E; Tanteles G; Vantyghem MC; Vatier C; Vigouroux C; Vorona E; Araujo-Vilar D; Wabitsch M

European lipodystrophy registry: background and structure. Journal Article

Orphanet journal of rare diseases, 15 (1), pp. 17, 2020.

Abstract | Links | BibTeX

Vasconcelos MH; Alcaro S; Arechavala-Gomeza V; Baumbach J; Borges F; Brevini TAL; Rivas JL; Devaux Y; Hozak P; Keinanen-Toivola MM; Lattanzi G; Mohr T; Murovska M; Prusty BK; Quinlan RA; Perez-Sala D; Scheibenbogen C; Schmidt HHHW; Silveira I; Tieri P; Tolios A; Riganti C

Joining European Scientific Forces to Face Pandemics. Journal Article

Trends in microbiology, S0966-842X(20) , pp. 30270-30275, 2020.

Abstract | Links | BibTeX

Evangelisti C; Paganelli F; Giuntini G; Mattioli E; Cappellini A; Ramazzotti G; Faenza I; Maltarello MC; Martelli AM; Scotlandi K; Chiarini F; Lattanzi G

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells Journal Article

Cells, 9 (3), pp. 774, 2020.

Abstract | Links | BibTeX

Cenni V; Capanni C; Mattioli E; Schena E; Squarzoni S; Bacalini MG; Garagnani P; Salvioli S; Franceschi C; Lattanzi G

Lamin A Involvement in Ageing Processes Journal Article

Ageing research reviews, 62 , pp. 101073, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

Experimental gerontology, 130 , pp. 110784, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

Experimental gerontology, 130 , pp. 110784, 2020.

Abstract | Links | BibTeX

Santi S; Cenni V; Capanni C; Lattanzi G; Mattioli E

PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation Journal Article

Cells, 9 (7), pp. E1735, 2020.

Abstract | Links | BibTeX

Cavaliere V; Lattanzi G; Andrenacci D

Silencing of Euchromatic Transposable Elements as a Consequence of Nuclear Lamina Dysfunction. Journal Article

Cells, 9 (3), pp. e625, 2020.

Abstract | Links | BibTeX

Andrenacci D; Cavaliere V; Lattanzi G

The role of transposable elements activity in aging and their possible involvement in laminopathic diseases. Journal Article

Ageing research reviews, 57 , pp. 100995, 2020.

Abstract | Links | BibTeX

Costa R; Rodia MT; Vianello S; Santi S; Lattanzi G; Angelini C; Pegoraro E; Cenacchi G

Transportin 3 (TNPO3) and related proteins in limb girdle muscular dystrophy D2 muscle biopsies: A morphological study and pathogenetic hypothesis Journal Article

Neuromuscular disorders, 2020.

Abstract | Links | BibTeX

2019

Chiarini F; Evangelisti C; Lattanzi G; McCubrey JA; Martelli AM

Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells. Journal Article

Biochimica et biophysica acta. Molecular cell research, 1866 (8), pp. 1322-1337, 2019.

Abstract | Links | BibTeX

Pellegrini C; Columbaro M; Schena E; Prencipe S; Andrenacci D; Iozzo P; Angela Guzzardi M; Capanni C; Mattioli E; Loi M; Araujo-Vilar D; Squarzoni S; Cinti S; Morselli P; Giorgetti A; Zanotti L; Gambineri A; Lattanzi G

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Journal Article

Experimental & molecular medicine., 51 (8), pp. 89, 2019.

Abstract | Links | BibTeX

Cenni V; Kojic S; Capanni C; Faulkner G; Lattanzi G

Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies. Journal Article

Oxidative medicine and cellular longevity, 2019 , pp. 7318796, 2019, (Review).

Abstract | Links | BibTeX

Ditaranto R; Boriani G; Biffi M; Lorenzini M; Graziosi M; Ziacchi M; Pasquale F; Vitale G; Berardini A; Rinaldi R; Lattanzi G; Potena L; Martin Suarez S; Bacchi Reggiani ML; Rapezzi C; Biagini E

Differences in cardiac phenotype and natural history of laminopathies with and without neuromuscular onset. Journal Article

Orphanet journal of rare diseases, 14 (1), pp. 263, 2019.

Abstract | Links | BibTeX

Aguado J; Sola-Carvajal A; Cancila V; Revêchon G; Ong PF; Jones-Weinert CW; Wallén Arzt E; Lattanzi G; Dreesen O; Tripodo C; Rossiello F; Eriksson M; d'Adda di Fagagna F

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome. Journal Article

Nature Communications, 10 (1), pp. 4990, 2019.

Abstract | Links | BibTeX

Mattioli E; Andrenacci D; Mai A; Valente S; Robijns J; De Vos WH; Capanni C; Lattanzi G

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C - Histone Deacetylase 2 Interaction in Human Cells. Journal Article

Frontiers in cell and developmental biology, 7 , pp. 6, 2019.

Abstract | Links | BibTeX

Chiarini F; Evangelisti C; Cenni V; Fazio A; Paganelli F; Martelli AM; Lattanzi G

The Cutting Edge: The Role of mTOR Signaling in Laminopathies. Journal Article

International journal of molecular sciences, 20 (4), pp. E847, 2019.

Abstract | Links | BibTeX

2018

Mattioli E; Andrenacci D; Garofalo C; Prencipe S; Scotlandi K; Remondini D; Gentilini D; Di Blasio AM; Valente S; Scarano E; Cicchilitti L; Piaggio G; Mai A; Lattanzi G

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. Journal Article

Aging cell, 17 (5), pp. e1282, 2018.

Abstract | Links | BibTeX

Zironi I; Gavoci E; Lattanzi G; Virelli A; Amorini F; Remondini D; Castellani G

BK channel overexpression on plasma membrane of fibroblasts from Hutchinson-Gilford progeria syndrome. Journal Article

Aging (Albany, NY), 10 (11), pp. 3148-3160, 2018.

Abstract | Links | BibTeX

Boriani G; Biagini E; Ziacchi M; Malavasi VL; Vitolo M; Talarico M; Mauro E; Gorlato G; Lattanzi G

Cardiolaminopathies from bench to bedside: challenges in clinical decision-making with focus on arrhythmia-related outcomes. Journal Article

Nucleus, 9 (1), pp. 442-459, 2018.

Abstract | Links | BibTeX

Bernasconi P; Carboni N; Ricci G; Siciliano G; Politano L; Maggi L; Mongini T; Vercelli L; Rodolico C; Biagini E; Boriani G; Ruggiero L; Santoro L; Schena E; Prencipe S; Evangelisti C; Pegoraro E; Morandi L; Columbaro M; Lanzuolo C; Sabatelli P; Cavalcante P; Cappelletti C; Bonne G; Muchir A; Lattanzi G

Elevated TGF beta2 serum levels in Emery-Dreifuss muscular dystrophy: implications for myocyte and tenocyte differentiation and fibrogenic processes. Journal Article

Nucleus, 25 (1), pp. 24, 2018.

Abstract | Links | BibTeX

Lattanzi G; Maggi L; Araujo-Vilar D

Laminopathies. Journal Article

Nucleus, 9 (1), pp. 543-544, 2018.

Links | BibTeX

Gargiuli C; Schena E; Mattioli E; Columbaro M; D'Apice MR; Novelli G; Greggi T; Lattanzi G

Lamins and bone disorders: current understanding and perspectives. Journal Article

Oncotarget, 9 (32), pp. 22817-22831, 2018.

Abstract | Links | BibTeX

Cenni V; D'Apice MR; Garagnani P; Columbaro M; Novelli G; Franceschi C; Lattanzi G

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. Journal Article

Ageing research reviews, 42 , pp. 1-13, 2018.

Abstract | Links | BibTeX

Jiang Z; Cinti C; Taranta M; Mattioli E; Schena E; Singh S; Khurana R; Lattanzi G; Tsinoremas NF; Capobianco E

Network assessment of demethylation treatment in melanoma: Differential transcriptome-methylome and antigen profile signatures. Journal Article

Plos One, 13 (11), pp. e0206686, 2018.

Abstract | Links | BibTeX

Mattioli E; Columbaro M; Jafferali MH; Schena E; Hallberg E; Lattanzi G

Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy. Journal Article

Cells, 7 (10), pp. pii: E170, 2018.

Abstract | Links | BibTeX

2017

Angori S; Capanni C; Faulkner G; Bean C; Boriani G; Lattanzi G; Cenni V

Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular Response to Oxidative Stress. Journal Article

Cellular Physiology and Biochemistry, 42 , pp. 169-184, 2017.

Abstract | Links | BibTeX

Cenni V; D'Apice MR; Garagnani P; Columbaro M; Novelli G; Franceschi C; Lattanzi G

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. Journal Article

Ageing research reviews, 42 , pp. 1-13, 2017.

Abstract | Links | BibTeX

2016

Loi M; Cenni V; Duchi S; Squarzoni S; Lopez-Otin C; Foisner R; Lattanzi G; Capanni C

Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes. Journal Article

Oncotarget, 7 (13), pp. 15662-15677, 2016.

Abstract | Links | BibTeX

Bellotti C; Capanni C; Lattanzi G; Donati D; Lucarelli E; Duchi S

Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level. Journal Article

Springerplus, 5 (1), pp. 1427, 2016.

Abstract | Links | BibTeX

Evangelisti C; Cenni V; Lattanzi G

Potential therapeutic effects of the mtor inhibitors for preventing ageing and progeria-related disorders. Journal Article

British Journal of Clinical Pharmacology (Literature Review), 82 (5), pp. 1229-1244, 2016.

Abstract | Links | BibTeX

Burla R; Carcuro M; Torre ML; Fratini F; Crescenzi M; D'Apice MR; Spitalieri P; Raffa GD; Astrologo L; Lattanzi G; Cundari E; Raimondo D; Biroccio A; Gatti M; Saggio I

The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence. Journal Article

Open Biology, 6 (8), pp. 160103, 2016.

Abstract | Links | BibTeX

2015

Pellegrini C; Columbaro M; Capanni C; D'Apice MR; Cavallo C; Murdocca M; Lattanzi G; Squarzoni S

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Journal Article

Oncotarget, 6 (30), pp. 29914-29928, 2015.

Abstract | Links | BibTeX

Lattanzi G

Chromatin dynamics and in vitro biomarkers in laminopathies: an overview Journal Article

Orphanet journal of rare diseases, 10 , 2015.

Links | BibTeX

Evangelisti C; Bernasconi P; Cavalcante P; Cappelletti C; D'Apice MR; Sbraccia P; Novelli G; Prencipe S; Lemma S; Baldini N; Avnet S; Squarzoni S; Martelli AM; Lattanzi G

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins. Journal Article

Oncotarget, 6 (10), pp. 7424-7437, 2015.

Abstract | Links | BibTeX

Di Pompo G; Salerno M; Rotili D; Valente S; Zwergel C; Avnet S; Lattanzi G; Baldini N; Mai A

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. Journal Article

Journal of Medicinal Chemistry, 58 (9), pp. 4073-4079, 2015.

Abstract | Links | BibTeX

Piva R; Lambertini E; Manferdini C; Capanni C; Penolazzi L; Gabusi E; Paolella F; Lolli A; Angelozzi M; Lattanzi G; Lisignoli G

Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes. Journal Article

Osteoarthritis and Cartilage, 23 (7), pp. 1226-1230, 2015.

Abstract | Links | BibTeX

2014

Camozzi D; Capanni C; Cenni V; Mattioli E; Columbaro M; Squarzoni S; Lattanzi G

Diverse lamin-dependent mechanisms interact to control chromatin dynamics: Focus on laminopathies Journal Article

Nucleus, 5 , pp. 427-440, 2014, ISSN: 1949-1034.

Abstract | Links | BibTeX

Lattanzi G; Ortolani M; Columbaro M; Prencipe S; Mattioli E; Lanzarini C; Maraldi NM; Cenni V; Garagnani P; Salvioli S; Storci G; Bonafe' M; Capanni C; Franceschi C

Lamins are rapamycin targets that impact human longevity: A study in centenarians Journal Article

Journal of Cell Science, 127 , pp. 147-157, 2014, ISSN: 1477-9137.

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Maggi L; D'Amico A; Pini A; Sivo S; Pane M; Ricci G; Vercelli L; D'Ambrosio P; Travaglini L; Sala S; Brenna G; Kapetis D; Scarlato M; Pegoraro E; Ferrari M; Toscano A; Benedetti S; Bernasconi P; Colleoni L; Lattanzi G; Bertini E; Mercuri E; Siciliano G; Rodolico C; Mongini T; Politano L; Previtali SC; Carboni N; Mantegazza R; Morandi L

LMNA-associated myopathies: The Italian experience in a large cohort of patients. Journal Article

Neurology, 83 , pp. 1634-1644, 2014, ISSN: 0028-3878.

Abstract | Links | BibTeX

Meinke P; Mattioli E; Haque F; Antoku S; Columbaro M; Straatman KR; Worman HJ; Gundersen GG; Lattanzi G; Wehnert M; Shackleton S

Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization Journal Article

PLOS genetics, 10 , pp. e1004605, 2014, ISSN: 1553-7390.

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Brancati F; Cocco E; Solla E; D’Apice MR; Mateddu A; Mcintyre A; Fadda E; Mura M; Lattanzi G; Piras R; Maioli MA; Marrosu G; Novelli G; Marrosu MG; Hegele RA; Carboni N

Partial lipodystrophy associated with muscular dystrophy of unknown genetic origin Journal Article

Muscle & nerve (Online), 49 , pp. 928–930, 2014, ISSN: 1097-4598.

Abstract | Links | BibTeX

Capanni C; Mattioli E; Columbaro M; Wehnert M; Ortolani M; Fini M; Novelli G; Bertacchini J; Maraldi NM; Marmiroli S; D'Apice MR; Prencipe S; Squarzoni S; Lattanzi G; Cenni V

Rapamycin treatment of Mandibuloacral Dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics Journal Article

Aging (Albany, N.Y. Online), 6 , pp. 755–770, 2014, ISSN: 1945-4589.

Abstract | Links | BibTeX