Giovanna Lattanzi


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 6366857
Fax: +39 051 4689922

E-mail: giovanna.lattanzi@cnr.it

Competences         

Cellular and molecular biology of the nucleus and nuclear envelope.

Muscle, bone and adipocyte cellular differentiation. Stable and primary cell cultures.

Expression of wild-type and mutated proteins in stable cells and in primary cultures.

Optical microscopy and immunofluorescence.


Scientific Activities

Study of lamins and nuclear envelope. Functional organization of the nucleus and chromatin.

Study of laminopathies: muscular dystrophies and lipodystrophies due to mutation of nuclear envelope proteins (Emery-Dreifuss dystrophies, Familial partial lipodystrophy), progeroid (Hutchinson-Gilford progeria, mandibuloacral dysplasia) and syndromic (Restricitve Dermopathy) laminopathies.

Study of nuclear envelope protein implications in muscle, adipocyte and bone tissue differentiation.


Recent Publications

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2024

Cenni V; Evangelisti C; Santi S; Sabatelli P; Neri S; Cavallo M; Lattanzi G; Mattioli E

Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation Journal Article

In: Cells, vol. 13, iss. 2, pp. 162, 2024.

Abstract | Links | BibTeX

2023

Marchionni E; D'Apice MR; Lupo V; Lattanzi G; Mattioli E; Lisignoli G; Gabusi E; Pepe G; Helmer Citterich M; Campione E; Nardone AM; Spitalieri P; Pucci N; Cocciadiferro D; Picchi E; Garaci F; Novelli A; Novelli G.

Clinical and functional characterization of COL2A1 p.Gly444Ser variant: From a fetal phenotype to a previously undisclosed postnatal phenotype Journal Article

In: Bone reports, vol. 19, pp. 101728, 2023.

Abstract | Links | BibTeX

Crochemore C; Chica C; Garagnani P; Lattanzi G; Horvath S; Sarasin A; Franceschi C; Bacalini MG; Ricchetti M

Epigenomic signature of accelerated ageing in progeroid Cockayne syndrome Journal Article

In: Aging Cell, vol. 22, iss. 10, pp. e13959, 2023.

Abstract | Links | BibTeX

Hartinger R; Lederer EM; Schena E; Lattanzi G; Djabali K

Impact of Combined Baricitinib and FTI Treatment on Adipogenesis in Hutchinson-Gilford Progeria Syndrome and Other Lipodystrophic Laminopathies Journal Article

In: Cells, vol. 12, iss. 10, pp. 1350, 2023.

Abstract | Links | BibTeX

2022

Montano V; Mancuso M; Simoncini C; Torri F; Chico L; Ali G; Rocchi A; Baldinotti F; Caligo MA; Lattanzi G; Mattioli E; Cenacchi G; Barison A; Siciliano G; Ricci G

A Single mtDNA Deletion in Association with a LMNA Gene New Frameshift Variant: A Case Report Journal Article

In: Journal of neuromuscular diseases, vol. 9, iss. 3457-462, 2022.

Abstract | Links | BibTeX

Valenti AC; Albini A; Imberti JF; Vitolo M; Bonini N; Lattanzi G; Schnabel RB; Boriani G

Clinical Profile, Arrhythmias, and Adverse Cardiac Outcomes in Emery-Dreifuss Muscular Dystrophies: A Systematic Review of the Literature Journal Article

In: Biology (Basel), vol. 11, iss. 4, 2022.

Abstract | Links | BibTeX

Czapiewski R; Batrakou DG; de Las Heras JI; Carter RN; Sivakumar A; Sliwinska M; Dixon CR; Webb S; Lattanzi G; Morton NM; Schirmer EC

Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy Journal Article

In: Nature communications, vol. 13, iss. 1, no. 321, 2022.

Abstract | Links | BibTeX

Chiarini F; Paganelli F; Balestra T; Capanni C; Fazio A; Manara MC; Landuzzi L; Petrini S; Evangelisti C; Lollini PL; Martelli AM; Lattanzi G; Scotlandi K

Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma Journal Article

In: Cell death & disease, vol. 13, iss. 4, pp. 346, 2022.

Abstract | Links | BibTeX

2021

Piazzi M; Kojic S; Capanni C; Stamenkovic N; Bavelloni A; Marin O; Lattanzi G; Blalock WL; Cenni V

Ectopic Expression of Ankrd2 Affects Proliferation, Motility and Clonogenic Potential of Human Osteosarcoma Cells. Journal Article

In: Cancers (Basel), vol. 13, no. 2, pp. e174, 2021.

Abstract | Links | BibTeX

Squarzoni S; Schena E; Sabatelli P; Mattioli E; Capanni C; Cenni V; D'Apice MR; Andrenacci D; Sarli G; Pellegrino V; Festa A; Baruffaldi F and Storci G; Bonafè M; Barboni C; Sanapo M; Zaghini A; Lattanzi G

Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice. Journal Article

In: Aging Cell, vol. 20, no. 1, pp. e13285, 2021.

Abstract | Links | BibTeX

Vasconcelos MH; Alcaro S; Arechavala-Gomeza V; Baumbach J; Borges F; Brevini TAL; Rivas JL; Devaux Y; Hozak P; Keinanen-Toivola MM; Lattanzi G; Mohr T; Murovska M; Prusty BK; Quinlan RA; Perez-Sala D; Scheibenbogen C; Schmidt HHHW; Silveira I; Tieri P; Tolios A; Riganti C

Joining European Scientific Forces to Face Pandemics. Journal Article

In: Trends in microbiology, vol. 29, no. 2, pp. 92-97, 2021.

Abstract | Links | BibTeX

Costa R; Rodia MT; Zini N; Pegoraro V; Marozzo R; Capanni C; Angelini C; Lattanzi G; Santi S; Cenacchi G

Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Journal Article

In: Molecular and cellular biochemistry, vol. 476, no. 4, pp. 1797-1811, 2021.

Abstract | Links | BibTeX

Giordani G; Cavaliere V; Gargiulo G; Lattanzi G; Andrenacci D

Retrotransposons Down- and Up-Regulation in Aging Somatic Tissue Journal Article

In: Cells, vol. 11, no. 1, pp. 79, 2021.

Abstract | Links | BibTeX

Maggi L; Mavroidis M; Psarras S; Capetanaki Y; Lattanzi G

Skeletal and Cardiac Muscle Disorders Caused by Mutations in Genes Encoding Intermediate Filament Proteins Journal Article

In: International journal of molecular sciences, vol. 22, no. 8, pp. 4256, 2021.

Abstract | Links | BibTeX

2020

Cappelletti C; Tramacere I; Cavalcante P; Schena E; Politano L; Carboni N; Gambineri A; D'Amico A; Ruggiero L; Ricci G; Siciliano G; Boriani G; Mongini TE; Vercelli L; Biagini E; Ziacchi M; D'Apice MR; Lattanzi G; Mantegazza R; Maggi L; Bernasconi P

Cytokine Profile in Striated Muscle Laminopathies: New Promising Biomarkers for Disease Prediction Journal Article

In: Cells, vol. 9, no. 6, pp. 1532, 2020.

Abstract | Links | BibTeX

Cenni V; Squarzoni S; Loi M; Mattioli E; Lattanzi G; Capanni C

Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization Journal Article

In: Cells, vol. 9, no. 6, pp. 1415, 2020.

Abstract | Links | BibTeX

von Schnurbein J; Adams C; Akinci B; Ceccarini G; D'Apice MR; Gambineri A; Hennekam RCM; Jeru I; Lattanzi G; Miehle K; Nagel G; Novelli G; Santini F; Santos Silva E; Savage DB; Sbraccia P; Schaaf J; Sorkina E; Tanteles G; Vantyghem MC; Vatier C; Vigouroux C; Vorona E; Araujo-Vilar D; Wabitsch M

European lipodystrophy registry: background and structure. Journal Article

In: Orphanet journal of rare diseases, vol. 15, no. 1, pp. 17, 2020.

Abstract | Links | BibTeX

von Schnurbein J; Adams C; Akinci B; Ceccarini G; D'Apice MR; Gambineri A; Hennekam RCM; Jeru I; Lattanzi G; Miehle K; Nagel G; Novelli G; Santini F; Santos Silva E; Savage DB; Sbraccia P; Schaaf J; Sorkina E; Tanteles G; Vantyghem MC; Vatier C; Vigouroux C; Vorona E; Araújo-Vilar D; Wabitsch M

European lipodystrophy registry: background and structure. Journal Article

In: Orphanet journal of rare diseases, vol. 15, no. 1, pp. 17, 2020.

Abstract | Links | BibTeX

Vasconcelos MH; Alcaro S; Arechavala-Gomeza V; Baumbach J; Borges F; Brevini TAL; Rivas JL; Devaux Y; Hozak P; Keinanen-Toivola MM; Lattanzi G; Mohr T; Murovska M; Prusty BK; Quinlan RA; Perez-Sala D; Scheibenbogen C; Schmidt HHHW; Silveira I; Tieri P; Tolios A; Riganti C

Joining European Scientific Forces to Face Pandemics. Journal Article

In: Trends in microbiology, vol. S0966-842X(20), pp. 30270-30275, 2020.

Abstract | Links | BibTeX

Evangelisti C; Paganelli F; Giuntini G; Mattioli E; Cappellini A; Ramazzotti G; Faenza I; Maltarello MC; Martelli AM; Scotlandi K; Chiarini F; Lattanzi G

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells Journal Article

In: Cells, vol. 9, no. 3, pp. 774, 2020.

Abstract | Links | BibTeX

Cenni V; Capanni C; Mattioli E; Schena E; Squarzoni S; Bacalini MG; Garagnani P; Salvioli S; Franceschi C; Lattanzi G

Lamin A Involvement in Ageing Processes Journal Article

In: Ageing research reviews, vol. 62, pp. 101073, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

In: Experimental gerontology, vol. 130, pp. 110784, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

In: Experimental gerontology, vol. 130, pp. 110784, 2020.

Abstract | Links | BibTeX

Jiang Z; Cinti C; Taranta M; Mattioli E; Schena E; Singh S; Khurana R; Lattanzi G; Tsinoremas NF; Capobianco E

Network assessment of demethylation treatment in melanoma: Differential transcriptome-methylome and antigen profile signatures. Journal Article

In: Plos One, vol. 13, no. 11, pp. e0206686, 2020.

Abstract | Links | BibTeX

Santi S; Cenni V; Capanni C; Lattanzi G; Mattioli E

PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation Journal Article

In: Cells, vol. 9, no. 7, pp. E1735, 2020.

Abstract | Links | BibTeX

Cavaliere V; Lattanzi G; Andrenacci D

Silencing of Euchromatic Transposable Elements as a Consequence of Nuclear Lamina Dysfunction. Journal Article

In: Cells, vol. 9, no. 3, pp. e625, 2020.

Abstract | Links | BibTeX

2019

Chiarini F; Evangelisti C; Lattanzi G; McCubrey JA; Martelli AM

Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells. Journal Article

In: Biochimica et biophysica acta. Molecular cell research, vol. 1866, no. 8, pp. 1322-1337, 2019.

Abstract | Links | BibTeX

Pellegrini C; Columbaro M; Schena E; Prencipe S; Andrenacci D; Iozzo P; Angela Guzzardi M; Capanni C; Mattioli E; Loi M; Araujo-Vilar D; Squarzoni S; Cinti S; Morselli P; Giorgetti A; Zanotti L; Gambineri A; Lattanzi G

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Journal Article

In: Experimental & molecular medicine., vol. 51, no. 8, pp. 89, 2019.

Abstract | Links | BibTeX

Cenni V; Kojic S; Capanni C; Faulkner G; Lattanzi G

Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies. Journal Article

In: Oxidative medicine and cellular longevity, vol. 2019, pp. 7318796, 2019, (Review).

Abstract | Links | BibTeX

Ditaranto R; Boriani G; Biffi M; Lorenzini M; Graziosi M; Ziacchi M; Pasquale F; Vitale G; Berardini A; Rinaldi R; Lattanzi G; Potena L; Martin Suarez S; Bacchi Reggiani ML; Rapezzi C; Biagini E

Differences in cardiac phenotype and natural history of laminopathies with and without neuromuscular onset. Journal Article

In: Orphanet journal of rare diseases, vol. 14, no. 1, pp. 263, 2019.

Abstract | Links | BibTeX

Aguado J; Sola-Carvajal A; Cancila V; Revêchon G; Ong PF; Jones-Weinert CW; Wallén Arzt E; Lattanzi G; Dreesen O; Tripodo C; Rossiello F; Eriksson M; d'Adda di Fagagna F

Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford Progeria Syndrome. Journal Article

In: Nature Communications, vol. 10, no. 1, pp. 4990, 2019.

Abstract | Links | BibTeX

Mattioli E; Andrenacci D; Mai A; Valente S; Robijns J; De Vos WH; Capanni C; Lattanzi G

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C - Histone Deacetylase 2 Interaction in Human Cells. Journal Article

In: Frontiers in cell and developmental biology, vol. 7, pp. 6, 2019.

Abstract | Links | BibTeX

2018

Mattioli E; Andrenacci D; Garofalo C; Prencipe S; Scotlandi K; Remondini D; Gentilini D; Di Blasio AM; Valente S; Scarano E; Cicchilitti L; Piaggio G; Mai A; Lattanzi G

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. Journal Article

In: Aging cell, vol. 17, no. 5, pp. e1282, 2018.

Abstract | Links | BibTeX

Zironi I; Gavoci E; Lattanzi G; Virelli A; Amorini F; Remondini D; Castellani G

BK channel overexpression on plasma membrane of fibroblasts from Hutchinson-Gilford progeria syndrome. Journal Article

In: Aging (Albany, NY), vol. 10, no. 11, pp. 3148-3160, 2018.

Abstract | Links | BibTeX

Boriani G; Biagini E; Ziacchi M; Malavasi VL; Vitolo M; Talarico M; Mauro E; Gorlato G; Lattanzi G

Cardiolaminopathies from bench to bedside: challenges in clinical decision-making with focus on arrhythmia-related outcomes. Journal Article

In: Nucleus, vol. 9, no. 1, pp. 442-459, 2018.

Abstract | Links | BibTeX

Bernasconi P; Carboni N; Ricci G; Siciliano G; Politano L; Maggi L; Mongini T; Vercelli L; Rodolico C; Biagini E; Boriani G; Ruggiero L; Santoro L; Schena E; Prencipe S; Evangelisti C; Pegoraro E; Morandi L; Columbaro M; Lanzuolo C; Sabatelli P; Cavalcante P; Cappelletti C; Bonne G; Muchir A; Lattanzi G

Elevated TGF beta2 serum levels in Emery-Dreifuss muscular dystrophy: implications for myocyte and tenocyte differentiation and fibrogenic processes. Journal Article

In: Nucleus, vol. 25, no. 1, pp. 24, 2018.

Abstract | Links | BibTeX

Lattanzi G; Maggi L; Araujo-Vilar D

Laminopathies. Journal Article

In: Nucleus, vol. 9, no. 1, pp. 543-544, 2018.

Links | BibTeX

Gargiuli C; Schena E; Mattioli E; Columbaro M; D'Apice MR; Novelli G; Greggi T; Lattanzi G

Lamins and bone disorders: current understanding and perspectives. Journal Article

In: Oncotarget, vol. 9, no. 32, pp. 22817-22831, 2018.

Abstract | Links | BibTeX

Cenni V; D'Apice MR; Garagnani P; Columbaro M; Novelli G; Franceschi C; Lattanzi G

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. Journal Article

In: Ageing research reviews, vol. 42, pp. 1-13, 2018.

Abstract | Links | BibTeX

Cenni V; D'Apice MR; Garagnani P; Columbaro M; Novelli G; Franceschi C; Lattanzi G

Mandibuloacral dysplasia: A premature ageing disease with aspects of physiological ageing. Journal Article

In: Ageing research reviews, vol. 42, pp. 1-13, 2018.

Abstract | Links | BibTeX

Di Pompo G; Salerno M; Rotili D; Valente S; Zwergel C; Avnet S; Lattanzi G; Baldini N; Mai A

Novel histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in sarcoma cancer stem cells. Journal Article

In: Journal of Medicinal Chemistry, vol. 58, no. 9, pp. 4073-4079, 2018.

Abstract | Links | BibTeX

2017

Angori S; Capanni C; Faulkner G; Bean C; Boriani G; Lattanzi G; Cenni V

Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular Response to Oxidative Stress. Journal Article

In: Cellular Physiology and Biochemistry, vol. 42, pp. 169-184, 2017.

Abstract | Links | BibTeX

2016

Loi M; Cenni V; Duchi S; Squarzoni S; Lopez-Otin C; Foisner R; Lattanzi G; Capanni C

Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes. Journal Article

In: Oncotarget, vol. 7, no. 13, pp. 15662-15677, 2016.

Abstract | Links | BibTeX

Bellotti C; Capanni C; Lattanzi G; Donati D; Lucarelli E; Duchi S

Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level. Journal Article

In: Springerplus, vol. 5, no. 1, pp. 1427, 2016.

Abstract | Links | BibTeX

Evangelisti C; Cenni V; Lattanzi G

Potential therapeutic effects of the mtor inhibitors for preventing ageing and progeria-related disorders. Journal Article

In: British Journal of Clinical Pharmacology (Literature Review), vol. 82, no. 5, pp. 1229-1244, 2016.

Abstract | Links | BibTeX

2015

Pellegrini C; Columbaro M; Capanni C; D'Apice MR; Cavallo C; Murdocca M; Lattanzi G; Squarzoni S

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Journal Article

In: Oncotarget, vol. 6, no. 30, pp. 29914-29928, 2015.

Abstract | Links | BibTeX

Lattanzi G

Chromatin dynamics and in vitro biomarkers in laminopathies: an overview Journal Article

In: Orphanet journal of rare diseases, vol. 10, 2015.

Links | BibTeX

Evangelisti C; Bernasconi P; Cavalcante P; Cappelletti C; D'Apice MR; Sbraccia P; Novelli G; Prencipe S; Lemma S; Baldini N; Avnet S; Squarzoni S; Martelli AM; Lattanzi G

Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins. Journal Article

In: Oncotarget, vol. 6, no. 10, pp. 7424-7437, 2015.

Abstract | Links | BibTeX

Mattioli E; Columbaro M; Jafferali MH; Schena E; Hallberg E; Lattanzi G

Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy. Journal Article

In: Cells, vol. 7, no. 10, pp. pii: E170, 2015.

Abstract | Links | BibTeX

Piva R; Lambertini E; Manferdini C; Capanni C; Penolazzi L; Gabusi E; Paolella F; Lolli A; Angelozzi M; Lattanzi G; Lisignoli G

Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes. Journal Article

In: Osteoarthritis and Cartilage, vol. 23, no. 7, pp. 1226-1230, 2015.

Abstract | Links | BibTeX

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