Giovanni Maga

Direttore

Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”
Via Abbiategrasso, 207 – 27100 PAVIA
tel: +39 0382 546361
fax: +39 0382 546370
E-mail: giovanni.maga@igm.cnr.it

CURRICULUM – download

Attività di Ricerca

Le aree scientifiche relative all’attività di ricerca del Dott. Maga sono:

  • Replicazione e riparazione del DNA nelle cellule eucariotiche umane e tumorali: enzimologia ed aspetti biochimici e molecolari.
  • Aspetti biochimici e molecolari della replicazione di virus umani a DNA e RNA (Herpes, HIV-1, Epatite C, influenza).
  • Meccanismi di farmacoresistenza e identificazione di nuovi bersagli molecolari e nuovi inibitori per la chemioterapia antivirale e antitumorale.

Dal 2007, in collaborazione con l’Università di Siena, il suo gruppo studia la proteina cellulare DDX3X come bersaglio per la terapia antivirale ad ampio spettro. Nel 2008 ha sviluppato una molecola in grado di bloccare la replicazione di HIV-1 agendo su DDX3X, aprendo così la strada ad una nuova strategia per il controllo dell’infezione da HIV-1 (1). La ricerca è stata finanziata da un grant della comunità Europea (FP6) e da una donazione della Sen. Franca Rame, attraverso la Fondazione Nobel Dario Fo. Nel 2016, ha dimostrato come questo approccio possa bloccare la replicazione anche di altri virus (Dengue, West Nile, Epatite C), aprendo la strada allo sviluppo di una classe interamente nuova di antivirali da ampio spettro (2). Queste ricerche sono proseguite con l’identificazione di inibitori sempre più selettivi per DDX3X (3).

(From: Riva et al. J Med Chem. 2020 Sep 10;63(17):9876-9887)

Inoltre, il suo gruppo collabora con diversi laboratori italiani e stranieri, effettuando la valutazione in vitro di piccole molecole dirette contro bersagli molecolari cellulari e virali e determinandone il meccanismo d’azione.

Nel campo della riparazione del DNA, ha contribuito a identificare il ruolo essenziale della DNA polimerasi lambda e beta nella tolleranza agli stress ossidativi (4) e il loro possibile ruolo nell’incorporazione di ribonucleotidi nel DNA durante la riparazione (5).

Recentemente, gli studi su DDX3X si sono estesi al suo ruolo nella tolleranza ai danni al DNA e nello viluppo tumorale, di fatto unendo le due linee di ricerca, con la dimostrazione che DDX3X possiede un’attività di tipo RNasico, in grado di complementare la RNasiH2 cellulare nella rimozione dei ribonucleotidi erroneamente incorporati nel genoma (6) e interagisce funzionalmente con la chinasi cellulare CK1epsilon (7).

(From: Riva et al. Nucleic Acids Res. 2020 Nov 18;48(20):11551-11565)

Bibliografia

  1. Maga et al., J Med Chem. 2008 Nov 13;51(21):6635-8. doi: 10.1021/jm8008844
  2. Brai et al., Proc. Nat. Acad. Sci. USA, 2016 May 10;113(19):5388-93. doi: 10.1073/pnas.1522987113.
  3. Riva et al. J Med Chem. 2020 Sep 10;63(17):9876-9887. doi:10.1021/acs.jmedchem.0c01039.
  4. Maga et al., Nature. 2007 May 31;447(7144):606-8
  5. Crespan et al., Nat Commun. 2016 Feb 26;7:10805. doi: 10.1038/ncomms10805
  6. Riva et al. Nucleic Acids Res. 2020 Nov 18;48(20):11551-11565. doi:10.1093/nar/gkaa948.
  7. Bono et al. Int J Mol Sci. 2020 Sep 3;21(17):6449. doi: 10.3390/ijms21176449.


Pubblicazioni Recenti

2021

Dede M; Napolitano S; Melati A; Pirota V; Maga G; Crespan E

High Flexibility of RNaseH2 Catalytic Activity with Respect to Non-Canonical DNA Structures Journal Article

International journal of molecular sciences, 22 (10), pp. 5201, 2021.

Abstract | Links | BibTeX

Mentegari E; Bertoletti F; Kissova M; Zucca E; Galli S; Tagliavini G; Garbelli A; Maffia A; Bione S; Ferrari E; d'Adda di Fagagna F; Francia S; Sabbioneda S; Chen LY; Lingner J; Bergoglio V; Hoffmann JS; Hubscher U; Crespan E; Maga G

A Role for Human DNA Polymerase lambda in Alternative Lengthening of Telomeres Journal Article

International journal of molecular sciences, 22 (5), pp. 2365, 2021.

Abstract | Links | BibTeX

2020

Riva V; Garbelli A; Brai A; Casiraghi F; Fazi R; Trivisani CI; Boccuto A; Saladini F; Vicenti I; Martelli F; Zazzi M; Giannecchini S; Dreassi E; Botta M; Maga G

Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses Journal Article

Journal of medicinal chemistry, 63 (17), pp. 9876-9877, 2020.

Abstract | Links | BibTeX

Lico C; Santi L; Baschieri S; Noris E; Marusic C; Donini M; Pedrazzini E; Maga G; Franconi R; Di Bonito P; Avesani

Plant Molecular Farming as a Strategy Against COVID-19 - The Italian Perspective. Journal Article

Frontiers in plant science, 11 , pp. 609910, 2020.

Abstract | Links | BibTeX

Squeglia F; Romano M; Ruggiero A; Maga G; Berisio R

Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins. Journal Article

Frontiers in chemistry, 8 , pp. 602162, 2020.

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Brai A; Riva V; Saladini F; Zamperini C; Trivisani CI; Garbelli A; Pennisi C; Giannini A; Boccuto A; Bugli F; Martini M; Sanguinetti M; Zazzi M; Dreassi E; Botta M; Maga G

DDX3X Inhibitors, an Effective Way to Overcome HIV-1 Resistance Targeting Host Proteins Journal Article

European journal of medicinal chemistry, 200 , pp. 112319, 2020.

Abstract | Links | BibTeX

Brai A; Boccuto A; Monti M; Marchi S; Vicenti I; Saladini F; Trivisani CI; Pollutri A; Trombetta CM; Montomoli E; Riva V; Garbelli A; Nola EM; Zazzi M; Maga G; Dreassi E; Botta M

Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor Journal Article

ACS medicinal chemistry letters, 11 (5), pp. 956-962, 2020.

Abstract | Links | BibTeX

Bono B; Franco G; Riva V; Garbelli A; Maga G

Novel Insights into the Biochemical Mechanism of CK1epsilon and its Functional Interplay with DDX3X Journal Article

International journal of molecular sciences, 21 (17), pp. E6449, 2020.

Abstract | Links | BibTeX

Nalli M; Armijos Rivera JI; Masci D; Coluccia A; Badia R; Riveira-Munoz E; Brambilla A; Cinquina E; Turriziani O; Falasca F; Catalano M; Limatola C; Este JA; Maga G; Silvestri R; Crespan E; La Regina G

New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains Journal Article

European journal of medicinal chemistry, 208 , pp. 112696, 2020.

Abstract | Links | BibTeX

Riva V; Garbelli A; Casiraghi F; Arena F; Trivisani CI; Gagliardi A; Bini L; Schroeder M; Maffia A; Sabbioneda S; Maga G

Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases. Journal Article

Nucleic acids research, 48 (20), pp. 11551-11565, 2020.

Abstract | Links | BibTeX

Romano M; Ruggiero A; Squeglia F; Maga G; Berisio R

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping Journal Article

Cells, 9 (5), pp. 1267, 2020.

Abstract | Links | BibTeX

2019

Brai A; Martelli F; Riva V; Garbelli A; Fazi R; Zamperini C; Pollutri A; Falsitta L; Ronzini S; Maccari L; Maga G; Giannecchini S; Botta M

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection. Journal Article

Journal of medicinal chemistry, 62 (5), pp. 2333-2347, 2019.

Abstract | Links | BibTeX

Riva V; Maga G

From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis. Journal Article

Future medicinal chemistry, 11 (11), pp. 1357-1381, 2019.

Abstract | Links | BibTeX

Fallacara AL; Passannanti R; Mori M; Iovenitti G; Musumeci F; Greco C; Crespan E; Kissova M; Maga G; Tarantelli C; Spriano F; Gaudio E; Bertoni F; Botta M; Schenone S

Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines. Journal Article

European journal of medicinal chemistry, 181 , pp. 111545, 2019.

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Bavagnoli L; Campanini G; Forte M; Ceccotti G; Percivalle E; Bione S; Lisa A; Baldanti F; Maga G

Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation. Journal Article

Antiviral research, 171 , pp. 104593, 2019.

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Geronikaki A; Petrou A; Kartsev V; Eleftheriou P; Boga R; Bartolo B; Crespan E; Franco G; Maga G

Molecular docking, design, synthesis and biological evaluation of novel 2,3-aryl-thiazolidin-4-ones as potent NNRTIs. Journal Article

SAR and QSAR in environmental research, 30 (10), pp. 697-714, 2019.

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Tassini S; Langron E; Delang L; Mirabelli C; Lanko K; Crespan E; Kissova M; Tagliavini G; Fontò G; Bertoni S; Palese S; Giorgio C; Ravanetti F; Ragionieri L; Zamperini C; Mancini A; Dreassi E; Maga G; Vergani P; Neyts J; Radi M

Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach Journal Article

Journal of medicinal chemistry, 62 (23), pp. 10833-10847, 2019.

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Brai A; Ronzini S; Riva V; Botta L; Zamperini C; Borgini M; Trivisani CI; Garbelli A; Pennisi C; Boccuto A; Saladini F; Zazzi M; Maga G; Botta M

Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X. Journal Article

Molecules, 24 (21), pp. pii: E3988, 2019.

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Nawrozkij M; Forgione M; Yablokov AS; Lucidi A; Tomaselli D; Patsilinakos A; Panella C; Hailu GS; Kirillov IA; Badia R; Riveira Muñoz E; Crespan E; Armijos-Rivera JI; Cirilli R; Ragno R; Este JA; Maga G; Mai A; Rotili D

Effect of alpha-Methoxy Substitution on the anti-HIV Activity of Dihydropyrimidin-4(3H)-ones. Journal Article

Journal of medicinal chemistry, 62 (2), pp. 604-621, 2019.

Abstract | Links | BibTeX

Maga G

Quando la cellula perde il controllo: capire il cancro per sconfiggerlo Book

Zanichelli, 2019, ISBN: 9788808120472.

Abstract | Links | BibTeX

2018

Kaptein SJF; Vincetti P; Crespan E; Rivera JIA; Costantino G; Maga G; Neyts J; Radi M

Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds. Journal Article

ChemMedChem, 13 (14), pp. 1371-1376, 2018.

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Molinari A; Fallacara AL; Di Maria S; Zamperini C; Poggialini F; Musumeci F; Schenone S; Angelucci A; Colapietro A; Crespan E; Kissova M; Maga G; Botta M

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment. Journal Article

Bioorganic & medicinal chemistry letters, 28 (21), pp. 3454-3457, 2018.

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2017

Mentegari E; Crespan E; Bavagnoli L; Kissova M; Bertoletti F; Sabbioneda S; Imhof R; Sturla SJ; Nilforoushan A; Hubscher U; van Loon B; Maga G

Ribonucleotide incorporation by human DNA polymerase eta impacts translesion synthesis and RNase H2 activity. Journal Article

Nucleic Acids Research, 45 (5), pp. 2600-2614, 2017.

Abstract | Links | BibTeX

Famiglini V; La Regina G; Coluccia A; Masci D; Brancale A; Badia R; Riveira-Munoz E; Esté JA; Crespan E; Brambilla A; Maga G; Catalano M; Limatola C; Formica FR; Cirilli R; Novellino E; Silvestri R

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents. Journal Article

Journal of medicinal chemistry, 60 (15), pp. 6528-6547, 2017.

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Tassini S; Sun L; Lanko K; Crespan E; Langron E; Falchi F; Kissova M; Armijos-Rivera JI; Delang L; Mirabelli C; Neyts J; Pieroni M; Cavalli A; Costantino G; Maga G; Vergani P; Leyssen P; Radi M

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. Journal Article

Journal of medicinal chemistry, 60 (4), pp. 1400-1416, 2017.

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Musumeci F; Fallacara AL; Brullo C; Grossi G; Botta L; Calandro P; Chiariello M; Kissova M; Crespan E; Maga G; Schenone S

Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma. Journal Article

European journal of medicinal chemistry, 127 , pp. 369-378, 2017.

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Garbelli A; Riva V; Crespan E; Maga G

How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher? Journal Article

Biochemical journal, 474 (10), pp. 1559-1577, 2017.

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van Loon B; Hubscher U; Maga G

Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis. Journal Article

Chemical research in toxicology, 30 (11), pp. 1936-1941, 2017.

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2016

Maga G

Batteri Spazzini e Virus che curano: come le biotecnologie riscrivono la vita Book

Zanichelli, Bologna, 2016, ISBN: 9788808920836.

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Brai A; Fazi R; Tintori C; Zamperini C; Bugli F; Sanguinetti M; Stigliano E; Este' J; Badia R; Franco S; Martinez MA; Martinez JP; Meyerhans A; Saladini F; Zazzi M; Garbelli A; Maga G; Botta M

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Journal Article

Proceedings of the National Academy of Sciences of the United States of America, 113 (9), pp. 5388-5393, 2016.

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Crespan E; Furrer A; Rösinger M; Bertoletti F; Mentegari E; Chiapparini G; Imhof R; Ziegler N; Sturla SJ; Hubscher U; van Loon B; Maga G

Impact of ribonucleotide incorporation by DNA polymerases beta and lambda on oxidative base excision repair. Journal Article

Nature Communications, 7 , pp. 10805, 2016.

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El-Moghazy SM; George RF; Osman EE; Elbatrawy AA; Kissova M; Colombo A; Crespan E; Maga G

Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line. Journal Article

European Journal of Medicinal Chemistry, 123 , pp. 1-13, 2016.

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Kissova M; Maga G; Crespan E

The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design. Journal Article

Bioorganic & Medicinal Chemistry, 24 (19), pp. 4555-4532, 2016.

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Goodson WH 3rd; Lowe L; Carpenter DO; Gilbertson M; Manaf Ali A; Lopez de Cerain Salsamendi A; Lasfar A; Carnero A; Azqueta A; Amedei A; Charles AK; Collins AR; Ward A; Salzberg AC; Colacci A; Olsen AK; Berg A; Barclay BJ; Zhou BP; Blanco-Aparicio C; Baglole CJ; Dong C; Mondello C; Hsu CW; Naus CC; Yedjou C; Curran CS; Laird DW; Koch DC; Carlin DJ; Felsher DW; Roy D; Brown DG; Ratovitski E; Ryan EP; Corsini E; Rojas E; Moon EY; Laconi E; Marongiu F; Al-Mulla F; Chiaradonna F; Darroudi F; Martin FL; Van Schooten FJ; Goldberg GS; Wagemaker G; Nangami G; Calaf GM; Williams G; Wolf GT; Koppen G; Brunborg G; Kim Lyerly H; Krishnan H; Ab Hamid H; Yasaei H; Sone H; Kondoh H; Salem HK; Hsu HY; Park HH; Koturbash I; Miousse IR; Scovassi AI; Klaunig JE; Vondráček J; Raju J; Roman J; Wise JP Sr; Whitfield JR; Woodrick J; Christopher JA; Ochieng J; Martinez-Leal JF; Weisz J; Kravchenko J; Sun J; Prudhomme KR; Narayanan KB; Cohen-Solal KA; Moorwood K; Gonzalez L; Soucek L; Jian L; D'Abronzo LS; Lin LT; Li L; Gulliver L; McCawley LJ; Memeo L; Vermeulen L; Leyns L; Zhang L; Valverde M; Khatami M; Romano MF; Chapellier M; Williams MA; Wade M; Manjili MH; Lleonart M; Xia M; Gonzalez MJ; Karamouzis MV; Kirsch-Volders M; Vaccari M; Kuemmerle NB; Singh N; Cruickshanks N; Kleinstreuer N; van Larebeke N; Ahmed N; Ogunkua O; Krishnakumar PK; Vadgama P; Marignani PA; Ghosh PM; Ostrosky-Wegman P; Thompson P; Dent P; Heneberg P; Darbre P; Sing Leung P; Nangia-Makker P; Cheng QS; Robey RB; Al-Temaimi R; Roy R; Andrade-Vieira R; Sinha RK; Mehta R; Vento R; Di Fiore R; Ponce-Cusi R; Dornetshuber-Fleiss R; Nahta R; Castellino RC; Palorini R; Abd Hamid R; Langie SA; Eltom S; Brooks SA; Ryeom S; Wise SS; Bay SN; Harris SA; Papagerakis S; Romano S; Pavanello S; Eriksson S; Forte S; Casey SC; Luanpitpong S; Lee TJ; Otsuki T; Chen T; Massfelder T; Sanderson T; Guarnieri T; Hultman T; Dormoy V; Odero-Marah V; Sabbisetti V; Maguer-Satta V; Rathmell WK; Engström W; Decker WK; Bisson WH; Rojanasakul Y; Luqmani Y; Chen Z; Hu Z Llona-Minguez S; Hoglund A; Jacques SA; Johansson L; Calderon-Montano JM; Claesson M; Loseva O; Valerie NC; Lundbäck T; Piedrafita J; Maga G; Crespan E; Meijer L; Burgos Morón E; Baranczewski P; Hagbjork AL; Svensson R; Wiita E; Almlof I; Visnes T; Jeppsson F; Sigmundsson K; Jensen AJ; Artursson P; Jemth AS; Stenmark P; Warpman Berglund U; Scobie M; Helleday T

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Journal Article

Journal of medicinal chemistry, 59 (3), pp. 1140-1148, 2016.

Abstract | Links | BibTeX

Tintori C; Brai A; Dasso Lang MC; Deodato D; Greco AM; Bizzarri BM; Cascone L; Casian A; Zamperini C; Dreassi E; Crespan E; Maga G; Vanham G; Ceresola E; Canducci F; Arien KK; Botta M

Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family. Journal Article

Journal of medicinal chemistry, 59 (6), pp. 2747-2759, 2016.

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Radi M; Schneider R; Fallacara AL; Botta L; Crespan E; Tintori C; Maga G; Kissova M; Calgani A; Richters A; Musumeci F; Rauh D; Schenone S

A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. Journal Article

Bioorganic & Medicinal Chemistry Letters, 26 (15), pp. 3436-3440, 2016.

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Mentegari E; Kissova M; Bavagnoli L; Maga G; Crespan E

DNA Polymerases lambda and beta: The Double-Edged Swords of DNA Repair. Journal Article

Genes (Basel), 7 (9), pp. e57, 2016.

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2015

Tintori C; Fallacara AL; Radi M; Zamperini C; Dreassi E; Crespan E; Maga G; Schenone S; Musumeci F; Brullo C; Richters A; Gasparrini F; Angelucci A; Festuccia C; Delle Monache S; Rauh D; Botta M

Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. Journal Article

Journal of Medicinal Chemistry, 58 (1), pp. 347-361, 2015.

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Vincetti P; Caporuscio F; Kaptein S; Gioiello A; Mancino V; Suzuki Y; Yamamoto N; Crespan E; Lossani A; Maga G; Rastelli G; Castagnolo D; Neyts J; Leyssen P; Costantino G; Radi M

Discovery of Multitarget Antivirals Acting on Both the Dengue Virus NS5-NS3 Interaction and the Host Src/Fyn Kinases. Journal Article

Journal of Medicinal Chemistry, 58 (12), 2015.

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Crespan E; Hübscher U; Maga G

Expansion of CAG triplet repeats by human DNA polymerases λ and β in vitro, is regulated by flap endonuclease 1 and DNA ligase 1. Journal Article

DNA Repair, 29 , pp. 101-111, 2015.

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Fazi R; Tintori C; Brai A; Botta L; Selvaraj M; Garbelli A; Maga G; Botta M

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors. Journal Article

Journal of Chemical Information and Modeling, 55 (11), pp. 2443-2454, 2015.

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Bavagnoli L; Cucuzza S; Campanini G; Rovida F; Paolucci S; Baldanti F; Maga G

The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA. Journal Article

Nucleic Acids Research, 43 (19), pp. 9405-9417, 2015.

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Spallarossa A; Caneva C; Caviglia M; Alfei S; Butini S; Campiani G; Gemma S; Brindisi M; Zisterer DM; Bright SA; Williams CD; Crespan E; Maga G; Sanna G; Delogu I; Collu G; Loddo R

Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents. Journal Article

European Journal of Medicinal Chemistry, 102 , pp. 648-660, 2015.

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Tintori C; La Sala G; Vignaroli G; Botta L; Fallacara AL; Falchi F; Radi M; Zamperini C; Dreassi E; Dello Iacono L; Orioli D; Biamonti G; Garbelli M; Lossani A; Gasparrini F; Tuccinardi T; Laurenzana I; Angelucci A; Maga G; Schenone S; Brullo C; Musumeci F; Desogus A; Crespan E; Botta M

Studies on the ATP Binding Site of Fyn Kinase for the Identification of New Inhibitors and Their Evaluation as Potential Agents against Tauopathies and Tumors. Journal Article

Journal of Medicinal Chemistry, 58 (11), pp. 4590-4609, 2015.

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2014

Maga G

AIDS: la verità negata Book

Il Pensiero Scientifico Editore, 2014, ISBN: 978-8849004809, (Vincitore del primo premio categoria saggi del Premio Letterario Nazionale Fanz Kafka - 2014).

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