Giovanni Maga

IGM Director

Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”
Via Abbiategrasso, 207 – 27100 PAVIA
tel: +39 0382 546361
fax: +39 0382 546370

CURRICULUM – download

Research activity

The scientific areas related to Dr. Maga’s research activity are:

  • DNA replication and repair in human and tumor cells: enzymology and biochemical and molecular aspects.
  • Biochemical and molecular aspects of the replication of human DNA and RNA viruses (Herpes, HIV-1, Hepatitis C, influenza).
  • Mechanisms of drug resistance and identification of new molecular targets and new inhibitors for antiviral and anticancer chemotherapy.

Since 2007, in collaboration with the University of Siena, his group has been studying the cellular protein DDX3X as a target for broad-spectrum antiviral therapy. In 2008 they developed a molecule capable of blocking HIV-1 replication by acting on DDX3X, thus paving the way for a new strategy for the control of HIV-1 infection (1). The research was funded by a grant from the European community (FP6) and by a donation from Sen. Franca Rame, through the Nobel Dario Fo Foundation. In 2016, they demonstrated how this approach can also block the replication of other viruses (Dengue, West Nile, Hepatitis C), paving the way for the development of an entirely new class of broad spectrum antivirals (2). These researches continued with the identification of increasingly selective inhibitors for DDX3X (3).

(From: Riva et al. J Med Chem. 2020 Sep 10;63(17):9876-9887)

In addition, his group collaborates with several Italian and foreign laboratories, carrying out the in vitro evaluation of small molecules directed against cellular and viral molecular targets and determining their mechanism of action.

In the field of DNA repair, his group helped to identify the essential role of DNA polymerases lambda and beta in tolerance to oxidative stresses (4) and their possible role in the incorporation of ribonucleotides into DNA during repair (5).

Recently, studies on DDX3X have extended to its role in DNA damage tolerance and tumor development, effectively combining the two lines of research, with the demonstration that DDX3X possesses an RNase-like activity, able to complement the Cellular RNaseH2 in the removal of ribonucleotides mistakenly incorporated into the genome (6) and functionally interacts with the cellular kinase CK1epsilon (7).

(From: Riva et al. Nucleic Acids Res. 2020 Nov 18;48(20):11551-11565)


  1. Maga et al., J Med Chem. 2008 Nov 13;51(21):6635-8. doi: 10.1021/jm8008844
  2. Brai et al., Proc. Nat. Acad. Sci. USA, 2016 May 10;113(19):5388-93. doi: 10.1073/pnas.1522987113.
  3. Riva et al. J Med Chem. 2020 Sep 10;63(17):9876-9887. doi:10.1021/acs.jmedchem.0c01039.
  4. Maga et al., Nature. 2007 May 31;447(7144):606-8
  5. Crespan et al., Nat Commun. 2016 Feb 26;7:10805. doi: 10.1038/ncomms10805
  6. Riva et al. Nucleic Acids Res. 2020 Nov 18;48(20):11551-11565. doi:10.1093/nar/gkaa948.
  7. Bono et al. Int J Mol Sci. 2020 Sep 3;21(17):6449. doi: 10.3390/ijms21176449.

Recent Publications

56 entries « 1 of 2 »


Barbieri F; Carlen V; Martina MG; Sannio F; Cancade S; Perini C; Restori M; Crespan E; Maga G; Docquier JD; Cagno V; Radi M.

4-Trifluoromethyl bithiazoles as broad-spectrum antimicrobial agents for virus-related bacterial infections or co-infections Journal Article

In: RSC medicinal chemistry, vol. 15, iss. 5, pp. 1589-1600, 2024.

Abstract | Links | BibTeX


Contadini C; Cirotti C; Carbone A; Norouzi M; Cianciusi A; Crespan E; Perini C; Maga G; Barilà D; Musumeci F; Schenone S

Identification and Biological Characterization of the Pyrazolo[3,4- d]pyrimidine Derivative SI388 Active as Src Inhibitor Journal Article

In: Pharmaceuticals - Basel, vol. 16, iss. 7, pp. 958, 2023.

Abstract | Links | BibTeX

Lodola C; Secchi M; Sinigiani V; De Palma A; Rossi R; Perico D; Mauri PL; Maga G

Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA Journal Article

In: International journal of molecular sciences, vol. 24, iss. 6, pp. 5784, 2023.

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Poggialini F; Vagaggini C; Brai A; Pasqualini C; Crespan E; Maga G; Perini C; Cabella N; Botta L; Musumeci F; Frosini M; Schenone S; Dreassi E

Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4- d]pyrimidines as Dual Tyrosine Kinase Inhibitors Active against Glioblastoma Multiforme Journal Article

In: Pharmaceutics, vol. 15, iss. 2, pp. 453, 2023.

Abstract | Links | BibTeX


Princiotto S; Musso L; Manetti F; Marcellini V; Maga G; Crespan E; Perini C; Zaffaroni N; Beretta GL; Dallavalle S

Synthesis and biological activity evaluation of 3-(hetero) arylideneindolin-2-ones as potential c-Src inhibitors Journal Article

In: Journal of enzyme inhibition and medicinal chemistry, vol. 37, iss. 1, pp. 2382-2394, 2022.

Abstract | Links | BibTeX

Secchi M; Lodola C; Garbelli A; Bione S; Maga G

DEAD-Box RNA Helicases DDX3X and DDX5 as Oncogenes or Oncosuppressors: A Network Perspective Journal Article

In: Cancers (Basel), vol. 14, iss. 15, pp. 3820, 2022.

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Di Maria S; Picarazzi F; Mori M; Cianciusi A; Carbone A; Crespan E; Perini C; Sabetta S; Deplano S; Poggialini F; Molinari A; Aronne R; Maccioni E; Maga G; Angelucci A; Schenone S; Musumeci F; Dreassi E

Novel pyrazolo[3,4-d]pyrimidines as dual Src/Bcr-Abl kinase inhibitors: Synthesis and biological evaluation for chronic myeloid leukemia treatment. Journal Article

In: Bioorganic chemistry, vol. 128, pp. 106071, 2022.

Abstract | Links | BibTeX

Cesarini S; Vicenti I; Poggialini F; Secchi M; Giammarino F; Varasi I; Lodola C; Zazzi M; Dreassi E; Maga G; Botta L; Saladino R

Privileged Scaffold Decoration for the Identification of the First Trisubstituted Triazine with Anti-SARS-CoV-2 Activity Journal Article

In: Molecules, vol. 27, iss. 24, pp. 8829, 2022.

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Brai A; Riva V; Clementi L; Falsitta L; Zamperini C; Sinigiani V; Festuccia C; Sabetta S; Aiello D; Roselli C; Garbelli A; Trivisani CI; Maccari L; Bugli F; Sanguinetti M; Calandro P; Chiariello M; Quaranta P; Botta L; Angelucci A; Maga G; Botta M

Targeting DDX3X Helicase Activity with BA103 Shows Promising Therapeutic Effects in Preclinical Glioblastoma Models Journal Article

In: Cancers (Basel), vol. 13, no. 21, pp. 5569, 2021.

Abstract | Links | BibTeX

Grazia Martina M; Vicenti I; Bauer L; Crespan E; Rango E; Boccuto A; Olivieri N; Incerti M; Zwaagstra M; Allodi M; Bertoni S; Dreassi E; Zazzi M; van Kuppeveld FJM; Maga G; Radi M

Bithiazole Inhibitors of Phosphatidylinositol 4-Kinase (PI4KIIIBETA) as Broad-Spectrum Antivirals Blocking the Replication of SARS-CoV-2, Zika Virus, and Human Rhinoviruses Journal Article

In: ChemMedChem, vol. 16, iss. 23, no. 3548, pp. 3552, 2021.

Abstract | Links | BibTeX

Vicenti I; Martina MG; Boccuto A; De Angelis M; Giavarini G; Dragoni F; Marchi S; Trombetta CM; Crespan E; Maga G; Eydoux C; Decroly E; Montomoli E; Nencioni L; Zazzi M; Radi M

System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2. Journal Article

In: European journal of medicinal chemistry, vol. 224, pp. 113683, 2021.

Abstract | Links | BibTeX

Dede M; Napolitano S; Melati A; Pirota V; Maga G; Crespan E

High Flexibility of RNaseH2 Catalytic Activity with Respect to Non-Canonical DNA Structures Journal Article

In: International journal of molecular sciences, vol. 22, no. 10, pp. 5201, 2021.

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Mentegari E; Bertoletti F; Kissova M; Zucca E; Galli S; Tagliavini G; Garbelli A; Maffia A; Bione S; Ferrari E; d'Adda di Fagagna F; Francia S; Sabbioneda S; Chen LY; Lingner J; Bergoglio V; Hoffmann JS; Hubscher U; Crespan E; Maga G

A Role for Human DNA Polymerase lambda in Alternative Lengthening of Telomeres Journal Article

In: International journal of molecular sciences, vol. 22, no. 5, pp. 2365, 2021.

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Riva V; Garbelli A; Brai A; Casiraghi F; Fazi R; Trivisani CI; Boccuto A; Saladini F; Vicenti I; Martelli F; Zazzi M; Giannecchini S; Dreassi E; Botta M; Maga G

Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses Journal Article

In: Journal of medicinal chemistry, vol. 63, no. 17, pp. 9876-9877, 2020.

Abstract | Links | BibTeX

Lico C; Santi L; Baschieri S; Noris E; Marusic C; Donini M; Pedrazzini E; Maga G; Franconi R; Di Bonito P; Avesani

Plant Molecular Farming as a Strategy Against COVID-19 - The Italian Perspective. Journal Article

In: Frontiers in plant science, vol. 11, pp. 609910, 2020.

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Squeglia F; Romano M; Ruggiero A; Maga G; Berisio R

Host DDX Helicases as Possible SARS-CoV-2 Proviral Factors: A Structural Overview of Their Hijacking Through Multiple Viral Proteins. Journal Article

In: Frontiers in chemistry, vol. 8, pp. 602162, 2020.

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Brai A; Riva V; Saladini F; Zamperini C; Trivisani CI; Garbelli A; Pennisi C; Giannini A; Boccuto A; Bugli F; Martini M; Sanguinetti M; Zazzi M; Dreassi E; Botta M; Maga G

DDX3X Inhibitors, an Effective Way to Overcome HIV-1 Resistance Targeting Host Proteins Journal Article

In: European journal of medicinal chemistry, vol. 200, pp. 112319, 2020.

Abstract | Links | BibTeX

Brai A; Boccuto A; Monti M; Marchi S; Vicenti I; Saladini F; Trivisani CI; Pollutri A; Trombetta CM; Montomoli E; Riva V; Garbelli A; Nola EM; Zazzi M; Maga G; Dreassi E; Botta M

Exploring the Implication of DDX3X in DENV Infection: Discovery of the First-in-Class DDX3X Fluorescent Inhibitor Journal Article

In: ACS medicinal chemistry letters, vol. 11, no. 5, pp. 956-962, 2020.

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Bono B; Franco G; Riva V; Garbelli A; Maga G

Novel Insights into the Biochemical Mechanism of CK1epsilon and its Functional Interplay with DDX3X Journal Article

In: International journal of molecular sciences, vol. 21, no. 17, pp. E6449, 2020.

Abstract | Links | BibTeX

Nalli M; Armijos Rivera JI; Masci D; Coluccia A; Badia R; Riveira-Munoz E; Brambilla A; Cinquina E; Turriziani O; Falasca F; Catalano M; Limatola C; Este JA; Maga G; Silvestri R; Crespan E; La Regina G

New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains Journal Article

In: European journal of medicinal chemistry, vol. 208, pp. 112696, 2020.

Abstract | Links | BibTeX

Riva V; Garbelli A; Casiraghi F; Arena F; Trivisani CI; Gagliardi A; Bini L; Schroeder M; Maffia A; Sabbioneda S; Maga G

Novel alternative ribonucleotide excision repair pathways in human cells by DDX3X and specialized DNA polymerases. Journal Article

In: Nucleic acids research, vol. 48, no. 20, pp. 11551-11565, 2020.

Abstract | Links | BibTeX

Romano M; Ruggiero A; Squeglia F; Maga G; Berisio R

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping Journal Article

In: Cells, vol. 9, no. 5, pp. 1267, 2020.

Abstract | Links | BibTeX


Tassini S; Langron E; Delang L; Mirabelli C; Lanko K; Crespan E; Kissova M; Tagliavini G; Fontò G; Bertoni S; Palese S; Giorgio C; Ravanetti F; Ragionieri L; Zamperini C; Mancini A; Dreassi E; Maga G; Vergani P; Neyts J; Radi M

Multitarget CFTR Modulators Endowed with Multiple Beneficial Side Effects for Cystic Fibrosis Patients: Toward a Simplified Therapeutic Approach Journal Article

In: Journal of medicinal chemistry, vol. 62, no. 23, pp. 10833-10847, 2019.

Abstract | Links | BibTeX

Bavagnoli L; Campanini G; Forte M; Ceccotti G; Percivalle E; Bione S; Lisa A; Baldanti F; Maga G

Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation. Journal Article

In: Antiviral research, vol. 171, pp. 104593, 2019.

Abstract | Links | BibTeX

Brai A; Ronzini S; Riva V; Botta L; Zamperini C; Borgini M; Trivisani CI; Garbelli A; Pennisi C; Boccuto A; Saladini F; Zazzi M; Maga G; Botta M

Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X. Journal Article

In: Molecules, vol. 24, no. 21, pp. pii: E3988, 2019.

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Fallacara AL; Passannanti R; Mori M; Iovenitti G; Musumeci F; Greco C; Crespan E; Kissova M; Maga G; Tarantelli C; Spriano F; Gaudio E; Bertoni F; Botta M; Schenone S

Identification of a new family of pyrazolo[3,4-d]pyrimidine derivatives as multitarget Fyn-Blk-Lyn inhibitors active on B- and T-lymphoma cell lines. Journal Article

In: European journal of medicinal chemistry, vol. 181, pp. 111545, 2019.

Abstract | Links | BibTeX

Geronikaki A; Petrou A; Kartsev V; Eleftheriou P; Boga R; Bartolo B; Crespan E; Franco G; Maga G

Molecular docking, design, synthesis and biological evaluation of novel 2,3-aryl-thiazolidin-4-ones as potent NNRTIs. Journal Article

In: SAR and QSAR in environmental research, vol. 30, no. 10, pp. 697-714, 2019.

Abstract | Links | BibTeX

Riva V; Maga G

From the magic bullet to the magic target: exploiting the diverse roles of DDX3X in viral infections and tumorigenesis. Journal Article

In: Future medicinal chemistry, vol. 11, no. 11, pp. 1357-1381, 2019.

Abstract | Links | BibTeX

Maga G

Quando la cellula perde il controllo: capire il cancro per sconfiggerlo Book

Zanichelli, 2019, ISBN: 9788808120472.

Abstract | Links | BibTeX

Brai A; Martelli F; Riva V; Garbelli A; Fazi R; Zamperini C; Pollutri A; Falsitta L; Ronzini S; Maccari L; Maga G; Giannecchini S; Botta M

DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection. Journal Article

In: Journal of medicinal chemistry, vol. 62, no. 5, pp. 2333-2347, 2019.

Abstract | Links | BibTeX

Nawrozkij M; Forgione M; Yablokov AS; Lucidi A; Tomaselli D; Patsilinakos A; Panella C; Hailu GS; Kirillov IA; Badia R; Riveira Muñoz E; Crespan E; Armijos-Rivera JI; Cirilli R; Ragno R; Este JA; Maga G; Mai A; Rotili D

Effect of alpha-Methoxy Substitution on the anti-HIV Activity of Dihydropyrimidin-4(3H)-ones. Journal Article

In: Journal of medicinal chemistry, vol. 62, no. 2, pp. 604-621, 2019.

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Kaptein SJF; Vincetti P; Crespan E; Rivera JIA; Costantino G; Maga G; Neyts J; Radi M

Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds. Journal Article

In: ChemMedChem, vol. 13, no. 14, pp. 1371-1376, 2018.

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Molinari A; Fallacara AL; Di Maria S; Zamperini C; Poggialini F; Musumeci F; Schenone S; Angelucci A; Colapietro A; Crespan E; Kissova M; Maga G; Botta M

Efficient optimization of pyrazolo[3,4-d]pyrimidines derivatives as c-Src kinase inhibitors in neuroblastoma treatment. Journal Article

In: Bioorganic & medicinal chemistry letters, vol. 28, no. 21, pp. 3454-3457, 2018.

Abstract | Links | BibTeX


van Loon B; Hubscher U; Maga G

Living on the Edge: DNA Polymerase Lambda between Genome Stability and Mutagenesis. Journal Article

In: Chemical research in toxicology, vol. 30, no. 11, pp. 1936-1941, 2017.

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Mentegari E; Crespan E; Bavagnoli L; Kissova M; Bertoletti F; Sabbioneda S; Imhof R; Sturla SJ; Nilforoushan A; Hubscher U; van Loon B; Maga G

Ribonucleotide incorporation by human DNA polymerase eta impacts translesion synthesis and RNase H2 activity. Journal Article

In: Nucleic Acids Research, vol. 45, no. 5, pp. 2600-2614, 2017.

Abstract | Links | BibTeX

Famiglini V; La Regina G; Coluccia A; Masci D; Brancale A; Badia R; Riveira-Munoz E; Esté JA; Crespan E; Brambilla A; Maga G; Catalano M; Limatola C; Formica FR; Cirilli R; Novellino E; Silvestri R

Chiral Indolylarylsulfone Non-Nucleoside Reverse Transcriptase Inhibitors as New Potent and Broad Spectrum Anti-HIV-1 Agents. Journal Article

In: Journal of medicinal chemistry, vol. 60, no. 15, pp. 6528-6547, 2017.

Abstract | Links | BibTeX

Garbelli A; Riva V; Crespan E; Maga G

How to win the HIV-1 drug resistance hurdle race: running faster or jumping higher? Journal Article

In: Biochemical journal, vol. 474, no. 10, pp. 1559-1577, 2017.

Abstract | Links | BibTeX

Tassini S; Sun L; Lanko K; Crespan E; Langron E; Falchi F; Kissova M; Armijos-Rivera JI; Delang L; Mirabelli C; Neyts J; Pieroni M; Cavalli A; Costantino G; Maga G; Vergani P; Leyssen P; Radi M

Discovery of Multitarget Agents Active as Broad-Spectrum Antivirals and Correctors of Cystic Fibrosis Transmembrane Conductance Regulator for Associated Pulmonary Diseases. Journal Article

In: Journal of medicinal chemistry, vol. 60, no. 4, pp. 1400-1416, 2017.

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Musumeci F; Fallacara AL; Brullo C; Grossi G; Botta L; Calandro P; Chiariello M; Kissova M; Crespan E; Maga G; Schenone S

Identification of new pyrrolo[2,3-d]pyrimidines as Src tyrosine kinase inhibitors in vitro active against Glioblastoma. Journal Article

In: European journal of medicinal chemistry, vol. 127, pp. 369-378, 2017.

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El-Moghazy SM; George RF; Osman EE; Elbatrawy AA; Kissova M; Colombo A; Crespan E; Maga G

Novel pyrazolo[3,4-d]pyrimidines as dual Src-Abl inhibitors active against mutant form of Abl and the leukemia K-562 cell line. Journal Article

In: European Journal of Medicinal Chemistry, vol. 123, pp. 1-13, 2016.

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Brai A; Fazi R; Tintori C; Zamperini C; Bugli F; Sanguinetti M; Stigliano E; Este' J; Badia R; Franco S; Martinez MA; Martinez JP; Meyerhans A; Saladini F; Zazzi M; Garbelli A; Maga G; Botta M

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents. Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 9, pp. 5388-5393, 2016.

Abstract | Links | BibTeX

Kissova M; Maga G; Crespan E

The human tyrosine kinase Kit and its gatekeeper mutant T670I, show different kinetic properties: Implications for drug design. Journal Article

In: Bioorganic & Medicinal Chemistry, vol. 24, no. 19, pp. 4555-4532, 2016.

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Crespan E; Furrer A; Rösinger M; Bertoletti F; Mentegari E; Chiapparini G; Imhof R; Ziegler N; Sturla SJ; Hubscher U; van Loon B; Maga G

Impact of ribonucleotide incorporation by DNA polymerases beta and lambda on oxidative base excision repair. Journal Article

In: Nature Communications, vol. 7, pp. 10805, 2016.

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Goodson WH 3rd; Lowe L; Carpenter DO; Gilbertson M; Manaf Ali A; Lopez de Cerain Salsamendi A; Lasfar A; Carnero A; Azqueta A; Amedei A; Charles AK; Collins AR; Ward A; Salzberg AC; Colacci A; Olsen AK; Berg A; Barclay BJ; Zhou BP; Blanco-Aparicio C; Baglole CJ; Dong C; Mondello C; Hsu CW; Naus CC; Yedjou C; Curran CS; Laird DW; Koch DC; Carlin DJ; Felsher DW; Roy D; Brown DG; Ratovitski E; Ryan EP; Corsini E; Rojas E; Moon EY; Laconi E; Marongiu F; Al-Mulla F; Chiaradonna F; Darroudi F; Martin FL; Van Schooten FJ; Goldberg GS; Wagemaker G; Nangami G; Calaf GM; Williams G; Wolf GT; Koppen G; Brunborg G; Kim Lyerly H; Krishnan H; Ab Hamid H; Yasaei H; Sone H; Kondoh H; Salem HK; Hsu HY; Park HH; Koturbash I; Miousse IR; Scovassi AI; Klaunig JE; Vondráček J; Raju J; Roman J; Wise JP Sr; Whitfield JR; Woodrick J; Christopher JA; Ochieng J; Martinez-Leal JF; Weisz J; Kravchenko J; Sun J; Prudhomme KR; Narayanan KB; Cohen-Solal KA; Moorwood K; Gonzalez L; Soucek L; Jian L; D'Abronzo LS; Lin LT; Li L; Gulliver L; McCawley LJ; Memeo L; Vermeulen L; Leyns L; Zhang L; Valverde M; Khatami M; Romano MF; Chapellier M; Williams MA; Wade M; Manjili MH; Lleonart M; Xia M; Gonzalez MJ; Karamouzis MV; Kirsch-Volders M; Vaccari M; Kuemmerle NB; Singh N; Cruickshanks N; Kleinstreuer N; van Larebeke N; Ahmed N; Ogunkua O; Krishnakumar PK; Vadgama P; Marignani PA; Ghosh PM; Ostrosky-Wegman P; Thompson P; Dent P; Heneberg P; Darbre P; Sing Leung P; Nangia-Makker P; Cheng QS; Robey RB; Al-Temaimi R; Roy R; Andrade-Vieira R; Sinha RK; Mehta R; Vento R; Di Fiore R; Ponce-Cusi R; Dornetshuber-Fleiss R; Nahta R; Castellino RC; Palorini R; Abd Hamid R; Langie SA; Eltom S; Brooks SA; Ryeom S; Wise SS; Bay SN; Harris SA; Papagerakis S; Romano S; Pavanello S; Eriksson S; Forte S; Casey SC; Luanpitpong S; Lee TJ; Otsuki T; Chen T; Massfelder T; Sanderson T; Guarnieri T; Hultman T; Dormoy V; Odero-Marah V; Sabbisetti V; Maguer-Satta V; Rathmell WK; Engström W; Decker WK; Bisson WH; Rojanasakul Y; Luqmani Y; Chen Z; Hu Z Llona-Minguez S; Hoglund A; Jacques SA; Johansson L; Calderon-Montano JM; Claesson M; Loseva O; Valerie NC; Lundbäck T; Piedrafita J; Maga G; Crespan E; Meijer L; Burgos Morón E; Baranczewski P; Hagbjork AL; Svensson R; Wiita E; Almlof I; Visnes T; Jeppsson F; Sigmundsson K; Jensen AJ; Artursson P; Jemth AS; Stenmark P; Warpman Berglund U; Scobie M; Helleday T

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1. Journal Article

In: Journal of medicinal chemistry, vol. 59, no. 3, pp. 1140-1148, 2016.

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Radi M; Schneider R; Fallacara AL; Botta L; Crespan E; Tintori C; Maga G; Kissova M; Calgani A; Richters A; Musumeci F; Rauh D; Schenone S

A cascade screening approach for the identification of Bcr-Abl myristate pocket binders active against wild type and T315I mutant. Journal Article

In: Bioorganic & Medicinal Chemistry Letters, vol. 26, no. 15, pp. 3436-3440, 2016.

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Mentegari E; Kissova M; Bavagnoli L; Maga G; Crespan E

DNA Polymerases lambda and beta: The Double-Edged Swords of DNA Repair. Journal Article

In: Genes (Basel), vol. 7, no. 9, pp. e57, 2016.

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Tintori C; Brai A; Dasso Lang MC; Deodato D; Greco AM; Bizzarri BM; Cascone L; Casian A; Zamperini C; Dreassi E; Crespan E; Maga G; Vanham G; Ceresola E; Canducci F; Arien KK; Botta M

Development and in Vitro Evaluation of a Microbicide Gel Formulation for a Novel Non-Nucleoside Reverse Transcriptase Inhibitor Belonging to the N-Dihydroalkyloxybenzyloxopyrimidines (N-DABOs) Family. Journal Article

In: Journal of medicinal chemistry, vol. 59, no. 6, pp. 2747-2759, 2016.

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Maga G

Batteri Spazzini e Virus che curano: come le biotecnologie riscrivono la vita Book

Zanichelli, Bologna, 2016, ISBN: 9788808920836.

Links | BibTeX


Fazi R; Tintori C; Brai A; Botta L; Selvaraj M; Garbelli A; Maga G; Botta M

Homology Model-Based Virtual Screening for the Identification of Human Helicase DDX3 Inhibitors. Journal Article

In: Journal of Chemical Information and Modeling, vol. 55, no. 11, pp. 2443-2454, 2015.

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Bavagnoli L; Cucuzza S; Campanini G; Rovida F; Paolucci S; Baldanti F; Maga G

The novel influenza A virus protein PA-X and its naturally deleted variant show different enzymatic properties in comparison to the viral endonuclease PA. Journal Article

In: Nucleic Acids Research, vol. 43, no. 19, pp. 9405-9417, 2015.

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56 entries « 1 of 2 »