A new family of DDX3X helicase inhibitors has been discovered to be effective in blocking West Nile virus replication in human cells without damaging healthy cells. The study conducted by research groups coordinated by Giovanni Maga (Institute of Molecular Genetics of the National Research Council of Pavia) and by Maurizio Botta (University of Siena), is published in the Journal of Medicinal Chemistry.
Brai A., Martelli F., Riva V., Garbelli A., Fazi R., Zamperini C. et al., DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection J. Med. Chem. Med Chem. 2019 Feb 21. doi: 10.1021/acs.jmedchem.8b01403