Iole Robuffo

Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Chieti
c/o Università “G. D’Annunzio” – Via dei Vestini CHIETI
tel: +39 0871 3554035
E-mail: iole.robuffo@cnr.it

Curriculum Vitae – Download

Elenco Completo delle Pubblicazioni – Download



Research Activities

The research activities concern the study of molecular, morphological and ultrastuctural constituents of the normal and pathological eukaryotic cell in various experimental conditions (apoptotic, antiproliferative, genotoxic conditions, etc.) and the prokaryotic cell using molecular biology techniques, microscopy optics, electronics and immunomicroscopy.

Study of the transduction mechanisms of cellular signals involved in the differentiation process, neoplastic progression and degenerative diseases, with a specific interest in adipogenic differentiation: adipokines and adipocytokines released from adipose tissue and their involvement in neuroendocrine, immune and cardiovascular diseases.

Metabolic syndrome is a major risk factor for cardiovascular and metabolic diseases. Obesity plays a central role in its development and in its clinical implications. Adipose tissue, considered as an endocrine organ due to its secreting activity of adipokines, contributes to the development of this pathology.

Adipogenesis is a continuous process in adult adipose tissue due to the presence of preadipocytes which, if appropriately stimulated, can proliferate and differentiate.


Recent Publications

2022

Ben Khalifa R; Cacciatore I; Dimmito MP; Ciulla M; Grande R; Puca V; Robuffo I; De Laurenzi V; Chekir-Ghedira L; Di Stefano A; Marinelli L

Multiple lipid nanoparticles as antimicrobial drug delivery systems Journal Article

In: Journal of drug delivery science and technology, vol. 67, pp. 102887, 2022.

Abstract | Links | BibTeX

Avolio F; Martinotti S; Khavinson VK; Esposito JE; Giambuzzi G; Marino A; Mironova E; Pulcini R; Robuffo I; Bologna G; Simeone P; Lanuti P; Guarnieri S; Trofimova S; Procopio AD; Toniato E.

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line Journal Article

In: International journal of molecular sciences, vol. 23, iss. 7, pp. 3607, 2022.

Abstract | Links | BibTeX

Avolio F; Martinotti S; Khavinson VK; Esposito JE; Giambuzzi G; Marino A; Mironova E; Pulcini R; Robuffo I; Bologna G; Simeone P; Lanuti P; Guarnieri S; Trofimova S; Procopio AD; Toniato E

Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line Journal Article

In: International journal of molecular sciences, vol. 23, iss. 7, pp. 3607, 2022.

Abstract | Links | BibTeX

Marinelli L; Ciulla M; Ritsema JAS; van Nostrum CF; Cacciatore I; Dimmito MP; Palmerio F; Orlando G; Robuffo I; Grande R; Puca V; Di Stefano A

Preparation, Characterization, and Biological Evaluation of a Hydrophilic Peptide Loaded on PEG-PLGA Nanoparticles Bachelor Thesis

2022.

Abstract | Links | BibTeX

2021

Pulcini R; Avolio F; Sinjari B; Robuffo I; Flati V; Pignatelli L; Martinotti S; Toniato E

Evaluation and efficiency of curcumin against periodontal bacteria: an in vitro study Journal Article

In: Journal of biological regulators and homeostatic agents, vol. 35, no. 2, pp. 725-728, 2021.

Abstract | Links | BibTeX

2020

Di Gregorio J; Robuffo I; Spalletta S; Giambuzzi G; De Iuliis V; Toniato E; Martinotti S; Conti P; Flati V

The Epithelial-to-Mesenchymal Transition as a Possible Therapeutic Target in Fibrotic Disorders. Journal Article

In: Frontiers in cell and developmental biology, vol. 8, pp. 607483, 2020.

Abstract | Links | BibTeX

2019

De Iuliis V; Ursi S; Pennelli A; Caruso M; Capodifoglio S; Marino A; Flati V; Vitullo G; Toniato E; Robuffo I; Martinotti S

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene. Journal Article

In: Journal of visualized experiments, vol. 146, pp. e57289, 2019.

Abstract | Links | BibTeX

Di Francesco S; Robuffo I; Caruso M; Giambuzzi G; Ferri D; Militello A; Toniato E

Metabolic Alterations, Aggressive Hormone-Naive Prostate Cancer and Cardiovascular Disease: A Complex Relationship. Journal Article

In: Medicina, vol. 55, no. 3, pp. 62, 2019.

Abstract | Links | BibTeX

Di Francesco S; Caruso M; Robuffo I; Militello A; Toniato E

The Impact of Metabolic Syndrome and Its Components on Female Sexual Dysfunction: A Narrative Mini-Review. Journal Article

In: Current urology, vol. 12, no. 2, pp. 57-63, 2019.

Abstract | Links | BibTeX

2018

Spalletta S; Flati V; Toniato E; Di Gregorio J; Marino A; Pierdomenico L; Marchisio M; D'Orazi G; Cacciatore I; Robuffo I

Carvacrol reduces adipogenic differentiation by modulating autophagy and ChREBP expression. Journal Article

In: Plos One, vol. 13, no. 11, pp. e0206894, 2018.

Abstract | Links | BibTeX

Matarazzo I; Toniato E; Robuffo I

Psychobiome Feeding Mind: Polyphenolics in Depression and Anxiety. Journal Article

In: Current topics in medicinal chemistry, vol. 18, no. 24, pp. 2108-2115, 2018.

Abstract | Links | BibTeX

2017

Toniato E; Frydas I; Robuffo I; Ronconi G; Caraffa Al; Kritas SK; Conti P

Activation and inhibition of adaptive immune response mediated by mast cells. Journal Article

In: Journal of biological regulators and homeostatic agents, vol. 31, no. 3, pp. 543-548, 2017.

Abstract | Links | BibTeX

De Iuliis V; Dadorante V; Marino A; Griffo I; Pennelli A; Breda V; Robuffo I; Ursi S; Martinotti S; Caputi S; Toniato E

Cytokine expression profile and blood parameter evaluation of patients undergoing cardiac surgery. Journal Article

In: Journal of biological regulators and homeostatic agents, vol. 31, no. 4, pp. 1109-1113, 2017.

Abstract | Links | BibTeX

Robuffo I; Toniato E; Tettamanti L; Mastrangelo F; Ronconi G; Frydas I; Caraffa A; Kritas SK; Conti P

Mast cell in innate immunity mediated by proinflammatory and antiinflammatory IL-1 family members. Journal Article

In: Journal of biological regulators and homeostatic agents, vol. 31, no. 4, pp. 837-842, 2017.

Abstract | Links | BibTeX

2016

Spoto G; De Iuliis V; Petrini M; Flati V; Di Gregorio J; Vitale D; Caruso M; Dadorante V; Ciarmoli M; Robuffo I; Martinotti S; Toniato E

Effect of low energy light irradiation by light emitting diode on U937 cells. Journal Article

In: Journal of Biological Regulators and Homeostatic Agents, vol. 30, no. 4, pp. 997-1007, 2016.

Abstract | Links | BibTeX

2015

Cacciatore I; Di Giulio M; Fornasari E; Di Stefano A; Cerasa LS; Marinelli L; Turkez H; Di Campli E; Di Bartolomeo S; Robuffo I; Cellini L

Carvacrol codrugs: a new approach in the antimicrobial plan. Journal Article

In: Plos One, vol. 10, no. 4, pp. e0120937, 2015.

Abstract | Links | BibTeX

Grande R; Di Marcantonio MC; Robuffo I; Pompilio A; Celia C; Di Marzio L; Paolino D; Codagnone M; Muraro R; Stoodley P; Hall-Stoodley L; Mincione G

Helicobacter pylori ATCC 43629/NCTC 11639 Outer Membrane Vesicles (OMVs) from Biofilm and Planktonic Phase Associated with Extracellular DNA (eDNA). Journal Article

In: Frontiers in virology, vol. 6, pp. 1369, 2015.

Abstract | Links | BibTeX