Telomeres as a target of a potential innovative therapy for the 10-15% of intractable tumors

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A possible therapeutic solution for treating ALT tumors has been identified in the IFOM laboratories, which include for example glioblastoma and osteosarcoma and against which chemotherapy and radiotherapy are not very effective. It is a therapy based on Antisense Oligonucleotides that acts on RNAs that promote the longevity of cancer cells of this type of tumor. The study, recently published in Nature Communications, was supported by the AIRC Foundation.

Ilaria Rosso, Corey Jones-Weinert, Francesca Rossiello, Matteo Cabrini, Silvia Brambillasca, Leonel Munoz-Sagredo, Zeno Lavagnino, Emanuele Martini, Enzo Tedone, Massimiliano Garre’, Julio Aguado, Dario Parazzoli, Marina Mione, Jerry W. Shay, Ciro Mercurio & Fabrizio d’Adda di Fagagna
Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs
Nat Commun. 2023 Nov 4;14(1):7086. doi: 10.1038/s41467-023-42831-0