Santi Spartaco


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone Office: +39 051 6366778
Phone Lab: +39 051 6366898

E-mail: spartaco.santi@cnr.it

Curriculum Vitae – Download

Elenco completo delle pubblicazioni – Download


Attività di ricerca

Il mio principale interesse scientifico è stata la ricerca di base nel campo della biologia cellulare, con l’utilizzo di nuovi approcci e tecnologie avanzate di microscopia ottica per migliorare la nostra comprensione della regolazione dell’assemblaggio e delle funzioni dei circuiti neuronali. In particolare: la neurogenesi adulta e la biologia delle cellule staminali nel cervello adulto; il ruolo delle neurotrofine nella regolazione della memoria; il traffico vescicolare di neurotrofine in neuroni ed astrociti; la secrezione di neurotrasmettitori e neuromodulatori osservati mediante tecniche di microscopia TIRF che consente la visualizzazione della fusione di singole vescicole sulla membrana plasmatica; la differenziazione degli oligodendrociti; il ruolo di p75 nei circuiti neuronali in vivo.
Un ulteriore argomento di indagine è stato il meccanismo molecolare dei disturbi neuromuscolari come: atassia di tipo 3; Epilessia mioclonica progressiva di tipo 1; malattie da prioni; distrofia muscolare di Emery-Dreifuss; miopatie correlate al collagene VI.
Particolare attenzione è stata posta nel corso degli anni all’imaging in vivo (time-lapse in fluorescenza e microscopia confocale con resonant scanner), tecnologie di super risoluzione (TIRF, SIM, STORM), tecnica di deep imaging (LightSheet, chiarificazione dei tessuti, uso degli obiettivi ad immersione in olio di silicone) ed infine immunogold con particelle d’oro colloidale per analisi ultrastrutturale in microscopia elettronica (TEM).


Gruppo di ricerca

Spartaco Santi Biologo CNR – IGM
Carola Cavallo PhD Biotecnologo Laboratorio RAMSES – Istituto Ortopedico Rizzoli
Azzurra Sargenti PhD Biologo CellDynamics
Deborah Ramini PhD B Biotecnologo Università Politecnica delle Marche
Elisabetta Palazzo PhD Biotecnologo Fondazione Umberto Veronesi


Pubblicazioni Recenti

2021

Costa R; Rodia MT; Zini N; Pegoraro V; Marozzo R; Capanni C; Angelini C; Lattanzi G; Santi S; Cenacchi G

Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Journal Article

Molecular and cellular biochemistry, 476 (4), pp. 1797-1811, 2021.

Abstract | Links | BibTeX

Neri S; Guidotti S; Bini C; Pelotti S; D'Adamo S; Minguzzi M; Platano D; Santi S; Mariani E; Cattini L; Borzì RM

Oxidative stress-induced DNA damage and repair in primary human osteoarthritis chondrocytes: focus on IKKα and the DNA Mismatch Repair System Journal Article

Free radical biology & medicine, 166 (212-225), 2021.

Abstract | Links | BibTeX

Cassandrini D; Merlini L; Pilla F; Cenni V; Santi S; Faldini C; Santorelli FM; Sabatelli P

Protein aggregates and autophagy involvement in a family with a mutation in Z-band alternatively spliced PDZ-motif protein. Journal Article

Neuromuscular disorders, S0960-8966 (20), pp. 30673-30678, 2021.

Abstract | Links | BibTeX

Cavallo C; Merli G; Borzì RM; Zini N; D'Adamo S; Guescini M; Grigolo B; Di Martino A; Santi S; Filardo G

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-kappaB dependent inflammatory/catabolic environment of osteoarthritis. Journal Article

Scientific Reports, 11 (1), pp. 1053, 2021.

Abstract | Links | BibTeX

Tesei A; Arienti C; Bossi G; Santi S; De Santis I; Bevilacqua A; Zanoni M; Pignatta S; Cortesi M; Zamagni A; Storci G; Bonafe' M; Sarnelli A; Romeo A; Cavallo C; Bartolazzi A; Rossi S; Soriani A; Strigari L

TP53 drives abscopal effect by secretion of senescence-associated molecular signals in non-small cell lung cancer. Journal Article

Journal of experimental & clinical cancer research, 40 (1), pp. 89, 2021.

Abstract | Links | BibTeX

2020

Cristaldi DA; Sargenti A; Bonetti S; Musmeci F; Delprete C; Bacchi F; Pasqua S; Cavallo C; Bonsi L; Alviano F; Gazzola D; Santi S

A Reliable Flow-Based Method for the Accurate Measure of Mass Density, Size and Weight of Live 3D Tumor Spheroids Journal Article

Micromachines (Basel), 11 (5), pp. E465, 2020.

Abstract | Links | BibTeX

Santi S; Cenni V; Capanni C; Lattanzi G; Mattioli E

PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation Journal Article

Cells, 9 (7), pp. E1735, 2020.

Abstract | Links | BibTeX

Minguzzi M; Guidotti S; Platano D; D'Adamo S; Cetrullo S; Assirelli E; Santi S; Mariani E; Trisolino G; Filardo G; Flamigni F; BorzI' RM

Polyamine supplementation reduces DNA damage in adipose stem cells cultured in 3-D. Journal Article

Scientific reports, 9 (1), pp. 14269, 2020.

Abstract | Links | BibTeX

D'Adamo S; Cetrullo S; Guidotti S; Silvestri Y; Minguzzi M; Santi S; Cattini L; Filardo G; Flamigni F; Borzi' RM

Spermidine Rescues the Deregulated Autophagic Response to Oxidative Stress of Osteoarthritic Chondrocytes Journal Article

Free radical biology & medicine, 153 , pp. 159-172, 2020.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Cappellini A; Paganelli F; Fini M; Santi S; Martelli AM; Neri LM; Evangelisti C

Targeting Wnt/beta-catenin and PI3K/Akt/mTOR pathways in T-cell acute lymphoblastic leukemia. Journal Article

Journal of cellular physiology, 235 (6), pp. 5413-5428, 2020.

Abstract | Links | BibTeX

Antoniel M; Traina F; Merlini L; Andrenacci D; Tigani D; Santi S; Cenni V; Sabatelli P; Faldini C; Squarzoni S

Tendon Extracellular Matrix Remodeling and Defective Cell Polarization in the Presence of Collagen VI Mutations. Journal Article

Cells, 9 (2), pp. e409, 2020.

Abstract | Links | BibTeX

Costa R; Rodia MT; Vianello S; Santi S; Lattanzi G; Angelini C; Pegoraro E; Cenacchi G

Transportin 3 (TNPO3) and related proteins in limb girdle muscular dystrophy D2 muscle biopsies: A morphological study and pathogenetic hypothesis Journal Article

Neuromuscular disorders, 2020.

Abstract | Links | BibTeX

2019

Storci G; De Carolis S; Papi A; Bacalini MG; Gensous N; Marasco E; Tesei A; Fabbri F; Arienti C; Zanoni M; Sarnelli A; Santi S; Olivieri F; Mensa' E; Latini S; Ferracin M; Salvioli S; Garagnani P; Franceschi C; Bonafe' M

Genomic stability, anti-inflammatory phenotype, and up-regulation of the RNAseH2 in cells from centenarians. Journal Article

Cell death and differentiation, 26 (9), pp. 1845-1858, 2019.

Abstract | Links | BibTeX

Minguzzi M; Guidotti S; Platano D; D'Adamo S; Cetrullo S; Assirelli E; Santi S; Mariani E; Trisolino G; Filardo G; Flamigni F; Borzì RM

Polyamine supplementation reduces DNA damage in adipose stem cells cultured in 3-D. Journal Article

Scientific reports, 9 (1), pp. 14269, 2019.

Abstract | Links | BibTeX

Pagani S; Minguzzi M; Sicuro L; Veronesi F; Santi S; Scotto D'Abusco A; Fini M; Borzì RM

The N-Acetyl Phenylalanine Glucosamine Derivative Attenuates the Inflammatory/Catabolic Environment in a Chondrocyte-Synoviocyte Co-Culture System. Journal Article

Scientific reports, 9 (1), pp. 13603, 2019.

Abstract | Links | BibTeX

2018

Gelfo V; Mazzeschi M; Grilli G; Lindzen M; Santi S; D'Uva G; Gyorffy B; Ardizzoni A; Yarden Y; Lauriola M

A Novel Role for the Interleukin-1 Receptor Axis in Resistance to Anti-EGFR Therapy. Journal Article

Cancers, 10 (10), pp. pii: E365, 2018.

Abstract | Links | BibTeX

Martella E; Ferroni C; Guerrini A; Ballestri M; Columbaro M; Santi S; Sotgiu G; Serra M; Donati DM; Lucarelli E; Varchi G; Duchi S

Functionalized Keratin as Nanotechnology-Based Drug Delivery System for the Pharmacological Treatment of Osteosarcoma. Journal Article

International journal of molecular sciences, 19 (11), pp. pii: E3670, 2018.

Abstract | Links | BibTeX

2017

Duchi S; Piccinini F; Pierini M; Bevilacqua A; Torre ML; Lucarelli E; Santi S

A new holistic 3D non-invasive analysis of cellular distribution and motility on fibroin-alginate microcarriers using light sheet fluorescent microscopy. Journal Article

Plos One, 12 (8), pp. e0183336, 2017.

Abstract | Links | BibTeX

Apolonio FM; Mazzoni A; Angeloni V; Scaffa PM; Santi S; Saboia VP; Tay FR; Pashley DH; Breschi L

Effect of a one-step self-etch adhesive on endogenous dentin matrix metalloproteinases. Journal Article

European journal of oral sciences, 125 (2), pp. 168-172, 2017.

Abstract | Links | BibTeX

Guidotti S; Minguzzi M; Platano D; Santi S; Trisolino G; Filardo G; Mariani E; Borzì RM

Glycogen Synthase Kinase-3beta Inhibition Links Mitochondrial Dysfunction, Extracellular Matrix Remodelling and Terminal Differentiation in Chondrocytes. Journal Article

Scientific reports, 7 (1), pp. 12059, 2017.

Abstract | Links | BibTeX

Maurizi G; Poloni A; Mattiucci D; Santi S; Maurizi A; Izzi V; Giuliani A; Mancini S; Zingaretti MC; Perugini J; Severi I; Falconi M; Vivarelli M; Rippo MR; Corvera S; Giordano A; Leoni P; Cinti S

Human White Adipocytes Convert Into ""Rainbow"" Adipocytes In Vitro. Journal Article

Journal of cellular physiology, 232 (10), pp. 2887-2899, 2017.

Abstract | Links | BibTeX

2016

Zanoni M; Piccinini F; Arienti C; Zamagni A; Santi S; Polico R; Bevilacqua A andTesei A

3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained. Journal Article

Scientific Reports, 6 , pp. 19103, 2016.

Abstract | Links | BibTeX

Gelfo V; Rodia MT; Pucci M; Dall'Ora M; Santi S; Solmi R; Roth L; Lindzen M; Bonafè M; Bertotti A; Caramelli E; Lollini PL; Trusolino L; Yarden Y; D'Uva G; Lauriola M

A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors. Journal Article

Oncotarget, 7 (44), pp. 72167-72183, 2016.

Abstract | Links | BibTeX

Sardone F; Santi S; Tagliavini F; Traina F; Merlini L; Squarzoni S; Cescon M; Wagener R; Maraldi NM; Bonaldo P; Faldini C; Sabatelli P

Collagen VI-NG2 axis in human tendon fibroblasts under conditions mimicking injury response. Journal Article

Matrix Biology, 55 , pp. 90-105, 2016.

Abstract | Links | BibTeX

Vignoli B; Battistini G; Melani R; Blum R; Santi S; Berardi N; Canossa M

Peri-Synaptic Glia Recycles Brain-Derived Neurotrophic Factor for LTP Stabilization and Memory Retention. Journal Article

Neuron, 92 (4), pp. 873-887, 2016.

Abstract | Links | BibTeX

Sardone F; Traina F; Bondi A; Merlini L; Santi S; Maraldi NM; Faldini C; Sabatelli P

Tendon Extracellular Matrix Alterations in Ullrich Congenital Muscular Dystrophy. Journal Article

Frontiers in Aging Neuroscience, 8 , pp. 131, 2016.

Abstract | Links | BibTeX

Sabatelli P; Sardone F; Traina F; Merlini L; Santi S; Wagener R; Faldini C

TGF-beta1 differentially modulates the collagen VI alpha5 and alpha6 chains in human tendon cultures. Journal Article

Journal of Biological Regulators and Homeostatic Agents, 30 (4), pp. 107-113, 2016.

Abstract | Links | BibTeX

2014

Sabatelli P; Castagnaro S; Tagliavini F; Chrisam M; Sardone F; Demay L; Richard P; Santi S; Maraldi NM; Merlini L; Sandri M; Bonaldo P.

Aggresome-autophagy involvement in a sarcopenic patient with rigid spine syndrome and a p.C150R mutation in FHL1 gene Journal Article

Frontiers in aging neuroscience, 6 , pp. 215, 2014, ISSN: 1663-4365.

Abstract | Links | BibTeX

Tagliavini F; Pellegrini C; Sardone F; Squarzoni S; Paulsson M; Wagener R; Gualandi F; Trabanelli C; Ferlini A; Merlini L; Santi S; Maraldi NM; Faldini C; Sabatelli P

Defective collagen VI alpha 6 chain expression in the skeletal muscle of patients with collagen VI-related myopathies Journal Article

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1842 , pp. 1604-1612, 2014, ISSN: 0925-4439.

Abstract | Links | BibTeX

Sardone F; Traina F; Tagliavini F; Pellegrini C; Merlini L; Squarzoni S; Santi S; Neri S; Faldini C; Maraldi N; Sabatelli P

Effect of mechanical strain on the collagen VI pericellular matrix in anterior cruciate ligament fibroblasts Journal Article

Journal of cellular physiology (Print), 229 , pp. 878-886, 2014, ISSN: 0021-9541.

Abstract | Links | BibTeX

Zulian A; Tagliavini F; Rizzo E; Pellegrini C; Sardone F; Zini N; Maraldi NM; Santi S; Faldini C; Merlini L; Petronilli V; Bernardi P; Sabatelli P

Melanocytes from Patients Affected by Ullrich Congenital Muscular Dystrophy and Bethlem Myopathy have Dysfunctional Mitochondria That Can be Rescued with Cyclophilin Inhibitors. Journal Article

Frontiers in Aging Neuroscience, 6 , pp. 324, 2014, ISSN: 1663-4365.

Abstract | Links | BibTeX

Bergami M; Vignoli B; Bony G; Pierchala BA; Santi S; Cancedda L; Canossa M.; Zuccaro E

Polarized Expression of p75(NTR) Specifies Axons during Development and Adult Neurogenesis Journal Article

Cell reports, 7 , pp. 138–152, 2014, ISSN: 2211-1247.

Abstract | Links | BibTeX