Silvia Bione

Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza”
Via Abbiategrasso, 207 – 27100 PAVIA
tel: +39 0382 546340
E-mail: silvia.bione@igm.cnr.it

Curriculum Vitae – Download

Complete List of Publications – Download


Research Activity

The comprehension of the molecular mechanisms involved in the physiology of human cells requires the development of new bioinformatics and biostatistics tools able to integrate and interpret the huge amount of data derived from different kind of genome-wide approaches. Recent technological developments made feasible the investigation of different aspects of cellular functioning by genome-wide approaches now requiring new bioinformatics tools for data analysis. The aim of our research is the development and the application of new bioinformatics methodology in the study of molecular mechanisms acting in the cell in normal or pathological conditions. 

In particular, in recent years our studies focused on the investigation of genomic and functional features of long non-coding RNAs (lncRNAs), a new class of molecules whose role in cellular physiology remains to be elucidate.


Research Projects

  • Transcriptional and splicing features of long non-coding RNA (lncRNAs)
  • Expression profiles of long non-coding RNA (lncRNAs) in Acute Myeloid Leukemia (AML) patients

Research Group

Roberta Alfieri, Technologist

Monah Abou Alezz, PhD student

Ludovica Celli, PhD student

Lorenzo Salviati, MD student

Giulia Belotti, MD student

Arianna Nicastro, MD student

 


Recent Publications

2023

Di Matteo A; Belloni E; Pradella D; Chiaravalli AM; Pini GM; Bugatti M; Alfieri R; Barzan C; Franganillo Tena E; Bione S; Terenzani E; Sessa F; Wyatt CDR; Vermi W; Ghigna C

Alternative Splicing Changes Promoted by NOVA2 Upregulation in Endothelial Cells and Relevance for Gastric Cancer Journal Article

In: International journal of molecular sciences, vol. 24, iss. 9, pp. 8102, 2023.

Abstract | Links | BibTeX

Lecca M; Bedeschi MF; Izzi C; Dordoni C; Rinaldi B; Peluso F; Caraffi SG; Prefumo F; Signorelli M; Zanzucchi M; Bione S; Ghigna C; Sassi S; Novelli A; Valente EM; Superti-Furga A; Garavelli L; Errichiello E

Identification of bi-allelic LFNG variants in three patients and further clinical and molecular refinement of spondylocostal dysostosis 3 Journal Article

In: Clinical genetics, vol. 104, iss. 2, pp. 230, 2023.

Abstract | Links | BibTeX

2022

Secchi M; Lodola C; Garbelli A; Bione S; Maga G

DEAD-Box RNA Helicases DDX3X and DDX5 as Oncogenes or Oncosuppressors: A Network Perspective Journal Article

In: Cancers (Basel), vol. 14, iss. 15, pp. 3820, 2022.

Abstract | Links | BibTeX

2021

Mentegari E; Bertoletti F; Kissova M; Zucca E; Galli S; Tagliavini G; Garbelli A; Maffia A; Bione S; Ferrari E; d'Adda di Fagagna F; Francia S; Sabbioneda S; Chen LY; Lingner J; Bergoglio V; Hoffmann JS; Hubscher U; Crespan E; Maga G

A Role for Human DNA Polymerase lambda in Alternative Lengthening of Telomeres Journal Article

In: International journal of molecular sciences, vol. 22, no. 5, pp. 2365, 2021.

Abstract | Links | BibTeX

Botta E; Theil AF; Raams A; Caligiuri G; Giachetti S; Bione S; Accadia M; Lombardi A; Smith DEC; Mendes MI; Swagemakers SMA; van der Spek PJ; Salomons GS; Hoeijmakers JHJ; Yesodharan D; Nampoothiri S; Ogi T; Lehmann AR; Orioli D; Vermeulen W

Protein instability associated with AARS1 and MARS1 mutations causes Trichothiodystrophy Journal Article

In: Human molecular genetics, vol. 30, iss. 18, no. 1711, pp. 1720, 2021.

Abstract | Links | BibTeX

Lombardi A; Arseni L; Carriero R; Compe E; Botta E; Ferri D; Uggè M; Biamonti G; Peverali FA; Bione S; Orioli D

Reduced levels of prostaglandin I 2 synthase: a distinctive feature of the cancer-free trichothiodystrophy Journal Article

In: Proceedings of the National Academy of Sciences of the United States of America., vol. 118, no. 26, 2021.

Abstract | Links | BibTeX

Silva B; Arora R; Bione S; Azzalin CM

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells. Journal Article

In: Nature communications, vol. 12, no. 1, pp. 3760, 2021.

Abstract | Links | BibTeX

2020

Abou Alezz M; Celli L; Belotti G; Lisa A; Bione S

GC-AG Introns Features in Long Non-coding and Protein-Coding Genes Suggest Their Role in Gene Expression Regulation Journal Article

In: Frontiers in Genetics - RNA, vol. 11, pp. 488-502, 2020.

Abstract | Links | BibTeX

2019

Theil AF; Botta E; Raams A; Smith DEC; Mendes MI; Caligiuri G; Giachetti S; Bione S; Carriero R; Liberi G; Zardoni L; Swagemakers SMA; Salomons GS; Sarasin A; Lehmann A; van der Spek PJ; Ogi T; Hoeijmakers JHJ; Vermeulen W; Orioli D

Bi-allelic TARS Mutations Are Associated with Brittle Hair Phenotype. Journal Article

In: American Journal of Human Genetics, vol. 105, no. 2, pp. 434-440, 2019.

Abstract | Links | BibTeX

Bavagnoli L; Campanini G; Forte M; Ceccotti G; Percivalle E; Bione S; Lisa A; Baldanti F; Maga G

Identification of a novel antiviral micro-RNA targeting the NS1 protein of the H1N1 pandemic human influenza virus and a corresponding viral escape mutation. Journal Article

In: Antiviral research, vol. 171, pp. 104593, 2019.

Abstract | Links | BibTeX

2015

Cremaschi P; Carriero R; Astrologo S; Colì C; Lisa A; Parolo S; Bione S

An Association Rule Mining Approach to Discover lncRNAs Expression Patterns in Cancer Datasets. Journal Article

In: Biomed Research International, vol. 2015, pp. 146250, 2015.

Abstract | Links | BibTeX

Parolo S; Lisa A; Gentilini D; Di Blasio AM; Barlera S; Nicolis EB; Boncoraglio GB; Parati EA; Bione S

Characterization of the biological processes shaping the genetic structure of the Italian population. Journal Article

In: BMC Genetics, vol. 16, pp. 132, 2015.

Abstract | Links | BibTeX

Cremaschi P; Oliverio M; Leva V; Bione S; Carriero R; Mazzucco G; Palamidessi A; Scita G; Biamonti G; Montecucco A

Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells. Journal Article

In: Plos One, vol. 10, no. 7, pp. e0130561, 2015.

Abstract | Links | BibTeX

Bluher A; Devan WJ; Holliday EG; Nalls M; Parolo S; Bione S; Giese AK; Boncoraglio GB; Maguire JM; Muller-Nurasyid M; Gieger C; Meschia JF; Rosand J; Rolfs A; Kittner SJ; Mitchell BD; O'Connell JR; Cheng YC

Heritability of young- and old-onset ischaemic stroke. Journal Article

In: European Journal of Neurology, vol. 22, no. 11, pp. 1488-1491, 2015.

Abstract | Links | BibTeX