Cristina Capanni


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 636856

E-mail: cristina.capanni@cnr.it

Curriculum Vitae – Download

Complete List of Publications – Download

Research Activity

My research topics include lamins and laminopathies; lamin A precursor (prelamin A processing); emerin; nuclear morphology and chromatin organization; molecular interaction between nuclear proteins and the nuclear lamina components. Bone, muscle and adipose tissue differentiation. My research activity focuses on nuclear envelope proteins, including lamins, emerin and BAF in chromatin and epigenetic dynamics under stress conditions as well as during cellular differentiation in bone, muscle and adipose tissue differentiation, of normal and biological samples from patients affected by muscular dystrophies, lipodystrophies and premature aging syndromes.

Laboratory techniques managed concern cell culturing, differentiation and transfection of primary cultures and cell lines; establishment and characterization of human and mouse primary cell cultures from bone, muscle and adipose tissue. Evaluation of protein expression by biochemical and optical microscopy approaches. Excellent abilities in the evaluation of protein-protein and protein-DNA interactions by approach of biochemistry (co-immunoprecipitation, CHIP assay) and immunocyto and immunohistochemistry (immunostaining and in situ Proximity Ligation Assay), as well as in imaging processing and data analysis by the use of NIS-Elements 4.3 AR software (Nikon) and Duolink® ImageTool (Sigma-Aldrich).

 


Recent Publications

2022

La Torre M; Merigliano C; Maccaroni K; Chojnowski A; Goh WI; Giubettini M; Vernì F; Capanni C; Rhodes D; Wright G; Burke B; Soddu S; Burla R; Saggio I

Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP Journal Article

In: Journal of experimental & clinical cancer research, vol. 41, iss. 1, pp. 273, 2022.

Abstract | Links | BibTeX

Chiarini F; Paganelli F; Balestra T; Capanni C; Fazio A; Manara MC; Landuzzi L; Petrini S; Evangelisti C; Lollini PL; Martelli AM; Lattanzi G; Scotlandi K

Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma Journal Article

In: Cell death & disease, vol. 13, iss. 4, pp. 346, 2022.

Abstract | Links | BibTeX

Capanni C; Schena E; Di Giampietro ML; Montecucco A; Mattioli E; Lattanzi G

The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment Journal Article

In: Frontiers in cell and developmental biology, vol. 10, 2022.

Abstract | Links | BibTeX

2021

Piazzi M; Kojic S; Capanni C; Stamenkovic N; Bavelloni A; Marin O; Lattanzi G; Blalock WL; Cenni V

Ectopic Expression of Ankrd2 Affects Proliferation, Motility and Clonogenic Potential of Human Osteosarcoma Cells. Journal Article

In: Cancers (Basel), vol. 13, no. 2, pp. e174, 2021.

Abstract | Links | BibTeX

Squarzoni S; Schena E; Sabatelli P; Mattioli E; Capanni C; Cenni V; D'Apice MR; Andrenacci D; Sarli G; Pellegrino V; Festa A; Baruffaldi F and Storci G; Bonafè M; Barboni C; Sanapo M; Zaghini A; Lattanzi G

Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice. Journal Article

In: Aging Cell, vol. 20, no. 1, pp. e13285, 2021.

Abstract | Links | BibTeX

Costa R; Rodia MT; Zini N; Pegoraro V; Marozzo R; Capanni C; Angelini C; Lattanzi G; Santi S; Cenacchi G

Morphological study of TNPO3 and SRSF1 interaction during myogenesis by combining confocal, structured illumination and electron microscopy analysis. Journal Article

In: Molecular and cellular biochemistry, vol. 476, no. 4, pp. 1797-1811, 2021.

Abstract | Links | BibTeX

2020

Cenni V; Squarzoni S; Loi M; Mattioli E; Lattanzi G; Capanni C

Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization Journal Article

In: Cells, vol. 9, no. 6, pp. 1415, 2020.

Abstract | Links | BibTeX

Cenni V; Capanni C; Mattioli E; Schena E; Squarzoni S; Bacalini MG; Garagnani P; Salvioli S; Franceschi C; Lattanzi G

Lamin A Involvement in Ageing Processes Journal Article

In: Ageing research reviews, vol. 62, pp. 101073, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

In: Experimental gerontology, vol. 130, pp. 110784, 2020.

Abstract | Links | BibTeX

Zaghini A; Sarli G; Barboni C; Sanapo M; Pellegrino V; Diana A; Linta N; Rambaldi J; D'Apice MR; Murdocca M; Baleani M; Baruffaldi F; Fognani R; Mecca R; Festa A; Papparella S; Paciello O; Prisco F; Capanni C; Loi M; Schena E; Lattanzi G; Squarzoni S

Long term breeding of the Lmna G609G progeric mouse: Characterization of homozygous and heterozygous models. Journal Article

In: Experimental gerontology, vol. 130, pp. 110784, 2020.

Abstract | Links | BibTeX

Santi S; Cenni V; Capanni C; Lattanzi G; Mattioli E

PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation Journal Article

In: Cells, vol. 9, no. 7, pp. E1735, 2020.

Abstract | Links | BibTeX

2019

Pellegrini C; Columbaro M; Schena E; Prencipe S; Andrenacci D; Iozzo P; Angela Guzzardi M; Capanni C; Mattioli E; Loi M; Araujo-Vilar D; Squarzoni S; Cinti S; Morselli P; Giorgetti A; Zanotti L; Gambineri A; Lattanzi G

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Journal Article

In: Experimental & molecular medicine., vol. 51, no. 8, pp. 89, 2019.

Abstract | Links | BibTeX

Cenni V; Kojic S; Capanni C; Faulkner G; Lattanzi G

Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies. Journal Article

In: Oxidative medicine and cellular longevity, vol. 2019, pp. 7318796, 2019, (Review).

Abstract | Links | BibTeX

Mattioli E; Andrenacci D; Mai A; Valente S; Robijns J; De Vos WH; Capanni C; Lattanzi G

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C - Histone Deacetylase 2 Interaction in Human Cells. Journal Article

In: Frontiers in cell and developmental biology, vol. 7, pp. 6, 2019.

Abstract | Links | BibTeX

2017

Angori S; Capanni C; Faulkner G; Bean C; Boriani G; Lattanzi G; Cenni V

Emery-Dreifuss Muscular Dystrophy-Associated Mutant Forms of Lamin A Recruit the Stress Responsive Protein Ankrd2 into the Nucleus, Affecting the Cellular Response to Oxidative Stress. Journal Article

In: Cellular Physiology and Biochemistry, vol. 42, pp. 169-184, 2017.

Abstract | Links | BibTeX

2016

Loi M; Cenni V; Duchi S; Squarzoni S; Lopez-Otin C; Foisner R; Lattanzi G; Capanni C

Barrier-to-Autointegration Factor (BAF) involvement in prelamin A-related chromatin organization changes. Journal Article

In: Oncotarget, vol. 7, no. 13, pp. 15662-15677, 2016.

Abstract | Links | BibTeX

Bellotti C; Capanni C; Lattanzi G; Donati D; Lucarelli E; Duchi S

Detection of mesenchymal stem cells senescence by prelamin A accumulation at the nuclear level. Journal Article

In: Springerplus, vol. 5, no. 1, pp. 1427, 2016.

Abstract | Links | BibTeX

2015

Pellegrini C; Columbaro M; Capanni C; D'Apice MR; Cavallo C; Murdocca M; Lattanzi G; Squarzoni S

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. Journal Article

In: Oncotarget, vol. 6, no. 30, pp. 29914-29928, 2015.

Abstract | Links | BibTeX

Ravera S; Capanni C; Tognotti D; Bottega R; Columbaro M; Dufour C; Cappelli E; Degan P

Inhibition of metalloproteinase activity in FANCA is linked to altered oxygen metabolism. Journal Article

In: Journal of Cellular Physiology, vol. 230, no. 3, 2015.

Abstract | Links | BibTeX

Piva R; Lambertini E; Manferdini C; Capanni C; Penolazzi L; Gabusi E; Paolella F; Lolli A; Angelozzi M; Lattanzi G; Lisignoli G

Slug transcription factor and nuclear Lamin B1 are upregulated in osteoarthritic chondrocytes. Journal Article

In: Osteoarthritis and Cartilage, vol. 23, no. 7, pp. 1226-1230, 2015.

Abstract | Links | BibTeX