Elisabetta Mattioli


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 6366768

E-mail: elisabetta.mattioli@cnr.it

Curriculum Vitae –  Download

Complete list of publications – Download

Research Interests

Research activity aimed at understanding the molecular mechanisms involved in the onset of laminopathies: a group of rare genetic pathologies mostly caused by LMNA mutations, the gene coding for the lamin A/C. Different roles have been attributed to the lamin A/C over the years, including the ability to regulate epigenetic enzymes activity and to act as a mechanosensor by transferring external information to the chromatin. In addition to studying how lamin A/C influences epigenetic enzymes activity, I’ve been studying the relationships between lamin A/C and LINC (Linker of Nucleoskeleton and Cytoskeleton) complex, a proteins platform located on the nuclear envelope, in order to understand lamin A/C involvement in mechanical signal transduction.

Research Projects

  • FOE2021 NUTRAGE Project “ Development of pharmacological strategies for metabolic diseases associated with aging”. From 2022 onwards.
  • PNRR “ECOSYSTEM FOR SUSTAINABLE TRANSITION IN EMILIA-ROMAGNA” (ECOSISTER) project “Materials for sustainability and ecological transition”. From 2022 onwards.
  • REte di Genomica Integrata per Nuove Applicazioni in medicina di precisione (REGINA) Project “Regenerative, predictive and personalized medicine”. From 2022 onwards.
  • PRIN PROGETTI DI RICERCA DI RILEVANTE INTERESSE NAZIONALE project “Mechanistic insights on the molecular signals underlying Collagen VI functions in muscle and tendon: a step forward for COL6-related myopathies”.  From 2023 onwards.
  • Associazione Italiana Progeria Sammy Basso onlus, (A.I.Pro.Sa.B.) From 2023 onwards.        
  • Agenzia del Farmaco Italiana (AIFA) project “Deflazacort TREATment LMNA, related congenital muscular dystrophy: study of clinical effectiveness and search for reliable biomarkers”. From 2019 onwards.

Research Group

FUNDAMENTAL MECHANISMS INVOLVED IN THE FUNCTIONS OF THE NUCLEAR MEMBRANE
Cristina Capanni, Vittoria Cenni, Elisa Schena, Giovanna Lattanzi,  Stefano Squarzoni

PATHOGENETIC MECHANISMS IN LAMINOPATHIES
Cristina Capanni, Vittoria Cenni , Elisa Schena,  Giovanna Lattanzi,  Stefano Squarzoni

 


Recent Publications

2024

Cenni V; Evangelisti C; Santi S; Sabatelli P; Neri S; Cavallo M; Lattanzi G; Mattioli E

Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation Journal Article

In: Cells, vol. 13, iss. 2, pp. 162, 2024.

Abstract | Links | BibTeX

2023

Marchionni E; D'Apice MR; Lupo V; Lattanzi G; Mattioli E; Lisignoli G; Gabusi E; Pepe G; Helmer Citterich M; Campione E; Nardone AM; Spitalieri P; Pucci N; Cocciadiferro D; Picchi E; Garaci F; Novelli A; Novelli G.

Clinical and functional characterization of COL2A1 p.Gly444Ser variant: From a fetal phenotype to a previously undisclosed postnatal phenotype Journal Article

In: Bone reports, vol. 19, pp. 101728, 2023.

Abstract | Links | BibTeX

Schena E; Mattioli E; Peres C; Zanotti L; Morselli P; Iozzo P; Guzzardi MA; Bernardini C; Forni M; Nesci S; Caprio M; Cecchetti C; Pagotto U; Gabusi E; Cattini L; Lisignoli G; Blalock W; Gambineri A; Lattanzi G.

Mineralocorticoid Receptor Antagonism Prevents Type 2 Familial Partial Lipodystrophy Brown Adipocyte Dysfunction Journal Article

In: CELLS, vol. 12, iss. 22, pp. 2586, 2023.

Abstract | Links | BibTeX

2022

Montano V; Mancuso M; Simoncini C; Torri F; Chico L; Ali G; Rocchi A; Baldinotti F; Caligo MA; Lattanzi G; Mattioli E; Cenacchi G; Barison A; Siciliano G; Ricci G

A Single mtDNA Deletion in Association with a LMNA Gene New Frameshift Variant: A Case Report Journal Article

In: Journal of neuromuscular diseases, vol. 9, iss. 3457-462, 2022.

Abstract | Links | BibTeX

Capanni C; Schena E; Di Giampietro ML; Montecucco A; Mattioli E; Lattanzi G

The role of prelamin A post-translational maturation in stress response and 53BP1 recruitment Journal Article

In: Frontiers in cell and developmental biology, vol. 10, 2022.

Abstract | Links | BibTeX

2021

Squarzoni S; Schena E; Sabatelli P; Mattioli E; Capanni C; Cenni V; D'Apice MR; Andrenacci D; Sarli G; Pellegrino V; Festa A; Baruffaldi F and Storci G; Bonafè M; Barboni C; Sanapo M; Zaghini A; Lattanzi G

Interleukin-6 neutralization ameliorates symptoms in prematurely aged mice. Journal Article

In: Aging Cell, vol. 20, no. 1, pp. e13285, 2021.

Abstract | Links | BibTeX

2020

Cenni V; Squarzoni S; Loi M; Mattioli E; Lattanzi G; Capanni C

Emerin Phosphorylation during the Early Phase of the Oxidative Stress Response Influences Emerin-BAF Interaction and BAF Nuclear Localization Journal Article

In: Cells, vol. 9, no. 6, pp. 1415, 2020.

Abstract | Links | BibTeX

Evangelisti C; Paganelli F; Giuntini G; Mattioli E; Cappellini A; Ramazzotti G; Faenza I; Maltarello MC; Martelli AM; Scotlandi K; Chiarini F; Lattanzi G

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells Journal Article

In: Cells, vol. 9, no. 3, pp. 774, 2020.

Abstract | Links | BibTeX

Cenni V; Capanni C; Mattioli E; Schena E; Squarzoni S; Bacalini MG; Garagnani P; Salvioli S; Franceschi C; Lattanzi G

Lamin A Involvement in Ageing Processes Journal Article

In: Ageing research reviews, vol. 62, pp. 101073, 2020.

Abstract | Links | BibTeX

Jiang Z; Cinti C; Taranta M; Mattioli E; Schena E; Singh S; Khurana R; Lattanzi G; Tsinoremas NF; Capobianco E

Network assessment of demethylation treatment in melanoma: Differential transcriptome-methylome and antigen profile signatures. Journal Article

In: Plos One, vol. 13, no. 11, pp. e0206686, 2020.

Abstract | Links | BibTeX

Santi S; Cenni V; Capanni C; Lattanzi G; Mattioli E

PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation Journal Article

In: Cells, vol. 9, no. 7, pp. E1735, 2020.

Abstract | Links | BibTeX

2019

Pellegrini C; Columbaro M; Schena E; Prencipe S; Andrenacci D; Iozzo P; Angela Guzzardi M; Capanni C; Mattioli E; Loi M; Araujo-Vilar D; Squarzoni S; Cinti S; Morselli P; Giorgetti A; Zanotti L; Gambineri A; Lattanzi G

Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning. Journal Article

In: Experimental & molecular medicine., vol. 51, no. 8, pp. 89, 2019.

Abstract | Links | BibTeX

Mattioli E; Andrenacci D; Mai A; Valente S; Robijns J; De Vos WH; Capanni C; Lattanzi G

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C - Histone Deacetylase 2 Interaction in Human Cells. Journal Article

In: Frontiers in cell and developmental biology, vol. 7, pp. 6, 2019.

Abstract | Links | BibTeX

2018

Mattioli E; Andrenacci D; Garofalo C; Prencipe S; Scotlandi K; Remondini D; Gentilini D; Di Blasio AM; Valente S; Scarano E; Cicchilitti L; Piaggio G; Mai A; Lattanzi G

Altered modulation of lamin A/C-HDAC2 interaction and p21 expression during oxidative stress response in HGPS. Journal Article

In: Aging cell, vol. 17, no. 5, pp. e1282, 2018.

Abstract | Links | BibTeX

Gargiuli C; Schena E; Mattioli E; Columbaro M; D'Apice MR; Novelli G; Greggi T; Lattanzi G

Lamins and bone disorders: current understanding and perspectives. Journal Article

In: Oncotarget, vol. 9, no. 32, pp. 22817-22831, 2018.

Abstract | Links | BibTeX

2015

Mattioli E; Columbaro M; Jafferali MH; Schena E; Hallberg E; Lattanzi G

Samp1 Mislocalization in Emery-Dreifuss Muscular Dystrophy. Journal Article

In: Cells, vol. 7, no. 10, pp. pii: E170, 2015.

Abstract | Links | BibTeX