Francesca Chiarini


Istituto di Genetica Molecolare “Luigi Luca Cavalli-Sforza” – Sede di Bologna
c/o Istituto Ortopedico Rizzoli -via di Barbiano 1/10
40136 Bologna 
Phone: +39 051 2091582

E-mail: francesca.chiarini@cnr.it

Curriculum Vitae – Download

Elenco completo delle pubblicazioni – Download

       

Attività di ricerca

– Organizzazione funzionale del nucleo e della cromatina in cellule tumorali, con particolare interesse allo studio delle lamine e delle proteine del LINC complex e al ruolo della lamina A/C nei sarcomi ossei (osteosarcoma e sarcoma di Ewing).

– Studio delle implicazioni delle proteine dell’involucro nucleare nel differenziamento, nella migrazione e nella proliferazione cellulare in modelli tumorali.

– Individuazione di molecole con un ruolo chiave nella insorgenza e nella progressione delle leucemie acute, con particolare attenzione al ruolo svolto dalla via di trasduzione del segnale imperniata su fosfoinositide 3-chinasi/Akt nella sopravvivenza e nella farmacoresistenza di cellule leucemiche umane.

– Regolazione epigenetica degli inositidi nel microambiente midollare durante la progressione della sindrome mielodisplastica (MDS) a leucemia acuta mieloide (LAM). Analisi della fosfolipasi C (PI-PLC) beta 1 e dei suoi bersagli del signalling fosfoinositidico: studi di metilazione e di espressione genica.

– Indentificazione di nuovi bersagli terapeutici per lo sviluppo ed il testing di molecole da utilizzare in associazione alla chemioterapia convenzionale nel trattamento delle neoplasie ematologiche e nei tumori ossei.

       

Progetti di ricerca

       

Gruppo di ricerca

Giovanna Lattanzi

Elisabetta Mattioli

Cristina Capanni

Camilla Evangelisti

Stefano Squarzoni


Collaborazioni

Università di Bologna

Università di Modena and Reggio Emilia

Policlinico S.Orsola-Malpighi, Istituto Seràgnoli, Bologna

Università di Roma TOR VRERGATA

Istituto Ortopedico Rizzoli  (IOR), Bologna

Università di Oxford, UK

Diatheva srl

 


Pubblicazioni Recenti

2021

Martelli AM; Evangelisti C; Paganelli F; Chiarini F; McCubrey JA

GSK-3: a multifaceted player in acute leukemias Journal Article Forthcoming

Leukemia, Forthcoming.

Abstract | Links | BibTeX

2020

Ratti S; Lonetti A; Follo MY; Paganelli F; Martelli AM; Chiarini F; Evangelisti C

B-ALL Complexity: Is Targeted Therapy Still A Valuable Approach for Pediatric Patients? Journal Article

Cancers, 12 (12), pp. E3498, 2020.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Paganelli F; Marmiroli S; Martelli AM

Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer. Journal Article

Biochimica et biophysica acta. Molecular cell research, 1867 (4), pp. 118635, 2020.

Abstract | Links | BibTeX

Lonetti A; Indio V; Laginestra MA; Tarantino G; Chiarini F; Astolfi A; Bertuccio SN; Martelli AM; Locatelli F; Pession A; Masetti R

Inhibition of Methyltransferase DOT1L Sensitizes to Sorafenib Treatment AML Cells Irrespective of MLL-Rearrangements: A Novel Therapeutic Strategy for Pediatric AML Journal Article

Cancers, 12 (7), pp. E1972, 2020.

Abstract | Links | BibTeX

Evangelisti C; Paganelli F; Giuntini G; Mattioli E; Cappellini A; Ramazzotti G; Faenza I; Maltarello MC; Martelli AM; Scotlandi K; Chiarini F; Lattanzi G

Lamin A and Prelamin A Counteract Migration of Osteosarcoma Cells Journal Article

Cells, 9 (3), pp. 774, 2020.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Cappellini A; Paganelli F; Fini M; Santi S; Martelli AM; Neri LM; Evangelisti C

Targeting Wnt/beta-catenin and PI3K/Akt/mTOR pathways in T-cell acute lymphoblastic leukemia. Journal Article

Journal of cellular physiology, 235 (6), pp. 5413-5428, 2020.

Abstract | Links | BibTeX

Chiarini F; Paganelli F; Martelli AM; Evangelisti C

The Role Played by Wnt/beta-Catenin Signaling Pathway in Acute Lymphoblastic Leukemia. Journal Article

International journal of molecular sciences, 21 (3), pp. e1098, 2020.

Abstract | Links | BibTeX

Martelli AM; Paganelli F; Chiarini F; Evangelisti C; McCubrey JA

The Unfolded Protein Response: A Novel Therapeutic Target in Acute Leukemias. Journal Article

Cancers, 12 (2), pp. e333, 2020.

Abstract | Links | BibTeX

2019

Chiarini F; Evangelisti C; Lattanzi G; McCubrey JA; Martelli AM

Advances in understanding the mechanisms of evasive and innate resistance to mTOR inhibition in cancer cells. Journal Article

Biochimica et biophysica acta. Molecular cell research, 1866 (8), pp. 1322-1337, 2019.

Abstract | Links | BibTeX

Mazzotti E; Teti G; Falconi M; Chiarini F; Barboni B; Mazzotti A; Muttini A

Age-Related Alterations Affecting the Chondrogenic Differentiation of Synovial Fluid Mesenchymal Stromal Cells in an Equine Model. Journal Article

Cells, 8 (10), pp. pii: E1116, 2019.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Paganelli F; Marmiroli S; Martelli AM

Crosstalks of GSK3 signaling with the mTOR network and effects on targeted therapy of cancer. Journal Article

Biochimica et biophysica acta. Molecular cell research, 1867 (4), pp. 118635, 2019.

Abstract | Links | BibTeX

Paganelli F; Lonetti A; Anselmi L; Martelli AM; Evangelisti C; Chiarini F

New advances in targeting aberrant signaling pathways in T-cell acute lymphoblastic leukemia. Journal Article

Advances in biological regulation, 74 , pp. 100649, 2019.

Abstract | Links | BibTeX

Ramazzotti G; Fiume R; Chiarini F; Campana G; Ratti S; Billi AM; Manzoli L; Follo MY; Suh PG; McCubrey J; Cocco L; Faenza I

Phospholipase C-beta1 interacts with cyclin E in adipose- derived stem cells osteogenic differentiation. Journal Article

Advances in biological regulation, 71 (1), pp. 9, 2019.

Abstract | Links | BibTeX

Chiarini F; Evangelisti C; Cenni V; Fazio A; Paganelli F; Martelli AM; Lattanzi G

The Cutting Edge: The Role of mTOR Signaling in Laminopathies. Journal Article

International journal of molecular sciences, 20 (4), pp. E847, 2019.

Abstract | Links | BibTeX

2018

Bertacchini J; Frasson C; Chiarini F; D'Avella D; Accordi B; Anselmi L; Barozzi P; Foghieri F; Luppi M; Martelli AM; Basso G; Najmaldin S; Khosravi A; Rahim F; Marmiroli S

Dual inhibition of PI3K/mTOR signaling in chemoresistant AML primary cells. Journal Article

Advances in biological regulation, 68 (2), pp. 9, 2018.

Abstract | Links | BibTeX

Evangelisti C; Cappellini A; Oliveira M; Fragoso R; Barata JT; Bertaina A; Locatelli F; Simioni C; Neri LM; Chiarini F; Lonetti A; Buontempo F; Orsini E; Pession A; Manzoli L; Martelli AM; Evangelisti C

Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia. Journal Article

Journal of cellular physiology, 233 (3), pp. 1796-1811, 2018.

Abstract | Links | BibTeX

Buontempo F; McCubrey JA; Orsini E; Ruzzene M; Cappellini A; Lonetti A; Evangelisti C; Chiarini F; Evangelisti C; Barata JT; Martelli AM

Therapeutic targeting of CK2 in acute and chronic leukemias. Journal Article

Leukemia, 32 (1), pp. 1-10, 2018.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; McCubrey JA; Martelli AM

Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update. Journal Article

International journal of molecular sciences, 19 (7), pp. pii: E1878, 2018.

Abstract | Links | BibTeX

2017

Masetti R; Bertuccio SN; Astolfi A; Chiarini F; Lonetti A; Indio V; De Luca M; Bandini J; Serravalle S; Franzoni M; Pigazzi M; Martelli AM; Basso G; Locatelli F; Pession A

Hh/Gli antagonist in acute myeloid leukemia with CBFA2T3-GLIS2 fusion gene. Journal Article

Journal of hematology & oncology , 10 (1), pp. 26, 2017.

Abstract | Links | BibTeX

2016

Chiarini F; Lonetti A; Evangelisti C; Buontempo F; Orsini E; Evangelisti C; Cappellini A; Neri LM; McCubrey JA; Martelli AM

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting. Journal Article

Biochimica Et Biophysica Acta (BBA) - Molecular Cell Research, 1863 (3), pp. 449-463, 2016.

Abstract | Links | BibTeX

Lonetti A; Cappellini A; Bertaina A; Locatelli F; Pession A; Buontempo F; Evangelisti C; Evangelisti C; Orsini E; Zambonin L; Neri LM; Martelli AM; Chiarini F

Improving nelarabine efficacy in T cell acute lymphoblastic leukemia by targeting aberrant PI3K/AKT/mTOR signaling pathway. Journal Article

Journal Of Hematology & Oncology , 9 (1), pp. 114, 2016.

Abstract | Links | BibTeX

Buontempo F; Orsini E; Lonetti A; Cappellini A; Chiarini F; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; Bertacchini J; Neri LM; McCubrey JA; Martelli AM

Synergistic cytotoxic effects of bortezomib and CK2 inhibitor CX-4945 in acute lymphoblastic leukemia: turning off the prosurvival ER chaperone BIP/Grp78 and turning on the pro-apoptotic NF-κB. Journal Article

Oncotarget, 7 (2), pp. 1323-1340, 2016.

Abstract | Links | BibTeX

Evangelisti C; Evangelisti C; Buontempo F; Lonetti A; Orsini E; Chiarini F; Barata JT; Pyne S; Pyne NJ; Martelli AM

Therapeutic potential of targeting sphingosine kinases and sphingosine 1-phosphate in hematological malignancies. Journal Article

Leukemia, 30 (11), pp. 2142-2151, 2016.

Abstract | Links | BibTeX

2015

Evangelisti C; Evangelisti C; Chiarini F; Lonetti A; Buontempo F; Neri LM; McCubrey JA; Martelli AM

Autophagy in acute leukemias: A double-edged sword with important therapeutic implications Journal Article

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853 (1), pp. 14-26, 2015.

Abstract | Links | BibTeX

Chiarini F; Evangelisti C; McCubrey JA; Martelli AM

Current treatment strategies for inhibiting mTOR in cancer Journal Article

Trends in Pharmacological Sciences, 36 (2), 2015.

Abstract | Links | BibTeX

Lonetti A; Cappellini A; Spartà AM; Chiarini F; Buontempo F; Evangelisti C; Evangelisti C; Orsini E; McCubrey JA; Martelli AM

PI3K pan-inhibition impairs more efficiently proliferation and survival of T-cell acute lymphoblastic leukemia cell lines when compared to isoform-selective PI3K inhibitors. Journal Article

Oncotarget, 6 (12), pp. 10399-10414, 2015.

Abstract | Links | BibTeX

Bavelloni A; Dmitrienko GI; Goodfellow VJ; Ghavami A; Piazzi M; Blalock WL; Chiarini F; Cocco L; Faenza I

PLCβ1a and PLCβ1b selective regulation and cyclin D3 modulation reduced by kinamycin F during k562 cell differentiation. Journal Article

Journal of Cellular Physiology, 230 (3), 2015.

Abstract | Links | BibTeX

2014

Lonetti A; Antunes IL; Chiarini F; Orsini E; Buontempo F; Ricci F; Tazzari PL; Pagliaro P; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Barata JT; Martelli AM

Activity of the pan-class I phosphoinositide 3-kinase inhibitor NVP-BKM120 in T-cell acute lymphoblastic leukemia Journal Article

Leukemia (Basingstoke, Online), 28 , pp. 1196-1206, 2014, ISSN: 1476-5551.

Abstract | Links | BibTeX

Evangelisti C; Evangelisti C; Teti G; Chiarini F; Falconi M; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Beak DJ; Bittman R; Pyne S; Pyne NJ; Martelli AM

Assessment of the effect of sphingosine kinase inhibitors on apoptosis,unfolded protein response and autophagy of T-cell acute lymphoblastic leukemia cells; Indications for novel therapeutics Journal Article

Oncotarget, 5 , pp. 7886-7901, 2014, ISSN: 1949-2553.

Abstract | Links | BibTeX

Buontempo F; Orsini E; Martins LR; Antunes I; Lonetti A; Chiarini F; Tabellini G; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Cappellini A; Barata JT; Martelli AM

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: Targeting the unfolded protein response signaling Journal Article

Leukemia (Basingstoke, Online), 28 , pp. 543-553, 2014, ISSN: 1476-5551.

Abstract | Links | BibTeX

Astolfi A; Vendemini F; Urbini M; Melchionda F; Masetti R; Franzoni M; Libri V; Serravalle S; Togni M; Paone G; Montemurro L; Bressanin D; Chiarini F; Martelli AM; Tonelli R; Pession A

MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia Journal Article

Oncotarget, 5 , pp. 120-130, 2014, ISSN: 1949-2553.

Abstract | Links | BibTeX

Evangelisti C; Chiarini F; Lonetti A; Buontempo F; Bressanin D; Cappellini A; Orsini E; McCubrey JA; Martelli AM; Evangelisti C

Therapeutic potential of targeting mTOR in T-cell acute lymphoblastic leukemia (Review) Journal Article

International journal of oncology, 45 , pp. 909–918, 2014, ISSN: 1019-6439.

Abstract | Links | BibTeX

Bressanin D; Chiarini F; Lonetti A; Cappellini A; Evangelisti C; Evangelisti C; Melchionda F; Pession A; Bertaina A; Locatelli F; McCubrey JA; Martelli AM; Sparta AM

Therapeutic targeting of Polo-like kinase-1 and Aurora kinases in T-cell acute lymphoblastic leukemia Journal Article

Cell cycle (Georget. Tex.), 13 , pp. 2237–2247, 2014, ISSN: 1538-4101.

Abstract | Links | BibTeX